IndraLab

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ATXN3 inhibits cell death. 3 / 6
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"Besides, the overexpression of Beclin1 has been shown to promote autophagy and decrease cell death caused by ataxin-3 aggregates in the brain tissues of SCA3 patients and poly-ataxin-3 mice [38]."
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"Overexpression of ATXN3 in polyQ neurodegeneration models in Drosophila suppresses toxicity and cell death, implying that ATXN3 is a neuroprotective protein; its neuroprotective action, moreover, depends both on its DUB activity and proper functioning of the proteasome."
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"These results are in complete agreement with previous reports showing that both depletion of ATXN3 and overexpression of pathogenic polyQ ATXN3 alleles caused disorganization of cytoskeleton and increased cell death in cultured cells (Neves-Carvalho et al., 2015; Rodrigues et al., 2010)."
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