IndraLab

Statements

USP14-C158V binds queuine. 4 / 4
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reach
"Also, in agreement with the structure of queuine bound Tgt (Cys158Val), the positioning of the Val158 main chain atoms suggests a shift of this residue towards the ligand which is not concomitant with a rotation of the Thr159 side chain."
23704982
reach
"Tgt (Cys158Val and Val233Gly) is, if at all, only to a minor extent able to bind queuine after the formation of this complex."
23704982
reach
"As in the structure of queuine bound Tgt (Cys158Val), nearly no electron density can be attributed to the side chain of Val158 in the Tgt (Cys158Val and Val233Gly)."
23704982
reach
"Superimposition of the queuine bound Tgt (Cys158Val) structure with the structure of Tgt in complex with RNA XREF_BIBR reveals that in the present conformation the dihydroxy-cyclopentenyl moiety of queuine sterically interferes with the ribose of the uracil 33 nucleotide and the phosphate at position 34."
23704982