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COPS5 increases the amount of MYC. 8 / 8
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"Interestingly, it has been reported that JAB1 knockdown stabilized MYC protein level, but inhibited MYC induced transcriptional activity [37], suggesting that JAB1 increased the turnover of MYC protei[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CSN5 was reported to directly regulate MYC transcriptional activity, but increased MYC protein level by affecting MYC turnover rate in breast cancer (44)."
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"Fourth, certain clinicopathological characteristics did not show an obvious difference regarding the expression of CSN5, which might be related to the variation in cut-off values and the lack of studies with a large sample.Furthermore, CSN5 can promote the transcription of MYC, an oncogenic transcription factor, target genes and induces its ubiquitination and turnover, thereby activating wound characteristics and inducing cancer cell proliferation and invasion [36], which might explain why CSN5 can affect tumor invasion depth."
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"JAB1 knockdown significantly decreased nuclear c-MYC expression, but not significantly decrease cytoplasmic Jagged1 expression."
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"Interestingly, Jab1/CSN5 knockdown stabilized MYC protein level, but inhibited MYC-induced transcriptional activity ( Adler et al., 2006 ), suggesting that Jab1/CSN5 increased the turnover of MYC prot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Jab1 also stabilizes certain proteins, such as hypoxia inducible factor 1alpha and c-Jun, and potentiates c-Jun and MYC transcription, which is responsible for the transcriptional activation of genes involved in cell proliferation, angiogenesis, and invasion."
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"JAB1 knockdown significantly decreased the expression of nuclear c-MYC, but not significantly decrease that of cytoplasmic Jagged1 ( Fig. 2 A, E, and 2F)."
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"These results suggest that JAB1 positively regulates the expression of nuclear β-catenin and c-MYC as a β-catenin/TCF4 target in COLO-320 cells.Next, to elucidate the role of JAB1 in cell cycle regula[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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