IndraLab

Statements

COPS5 increases the amount of MYC. 3 / 3
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"CSN5 was reported to directly regulate MYC transcriptional activity, but increased MYC protein level by affecting MYC turnover rate in breast cancer (44)."
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"Jab1 also stabilizes certain proteins, such as hypoxia inducible factor 1alpha and c-Jun, and potentiates c-Jun and MYC transcription, which is responsible for the transcriptional activation of genes involved in cell proliferation, angiogenesis, and invasion."
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"Interestingly, it has been reported that JAB1 knockdown stabilized MYC protein level, but inhibited MYC induced transcriptional activity [37], suggesting that JAB1 increased the turnover of MYC protei[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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