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USP7 decreases the amount of CD274. 11 / 11
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"On the contrary, another study found that USP7 inhibition elevated the PD-L1 expression in lung cancer cells [57], suggesting that the regulation of PD-L1 expression by USP7 is multifaceted and may be context-dependent.Different subsets of DCs are specialized for eliciting specific elements of the immune response."
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"However, a related study showed that inhibiting USP7 increased the expression of PD-L1 in lung cancer cells (Dai et al., 2020), and higher levels of USP7 promoted tumor growth by altering the immunosuppressive characteristics of Forkhead box protein P3 (Foxp3) Treg (Gao et al., 2023)."
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"Hence, USP7 suppression by its inhibitors not only blocked gastric tumor cell proliferation but also inhibit the expression of PD-L1 to improve anti-cancer immune response in gastric cancer (129)."
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"In addition, the targeted inhibition of USP7 significantly increases PD-L1 protein levels in both cancer cells and the tumor microenvironment."
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"As USP7 expression was positively correlated with PD-L1 expression in human GC tissues and abrogation of USP7 decreased the expression of PD-L1 in different GC cell lines, we next asked how USP7 regulates the PD-L1 expression."
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"As USP7 abrogation can decrease the expression of PD-L1 without impacting on its mRNA level, and PD-L1 was reported to be ubiquitinated and subjected to proteasome mediated degradation XREF_BIBR, XREF_BIBR, whether USP7 erases the ubiquitination of PD-L1 needs to be answered."
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"All these results indicate that USP7 abrogation can decrease the expression level of PD-L1 in GC cells."
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"Inhibition of USP7 may inhibit the proliferation of gastric cancer cells by halting the cell cycle during the G2-M phase, maintaining p53 expression, and downregulating PD-L1 expression."
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"However, previous Dai’s study found that USP7 inhibition actually elevated the PD-L1 expression in lung cancer cells (Fig. 1B) [59]."
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"The inhibition of USP7 also upregulates PD-L1 level in tumor microenvironment."
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"In addition, targeting USP7 promoted the infiltration and cytotoxicity of CD8 T cells in the TME and decreased PD-L1 expression in tumor cells (81, 82)."
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