IndraLab

Statements

Hydroxychloroquine inhibits viral load. 40 / 40
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"In early clinical studies , chloroquine and hydroxychloroquine were suggested to reduce viral load and improve clinical outcomes in individuals with COVID-19 ( Gao et al ., 2020 ; Gautret et al ., 2020 ) with an even better effect when combined with azithromycin ( Gautret et al ., 2020 ) ."
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"A Phase 2 multi-center open-labeled randomized clinical trial is being conducted in Korea on 150 participants which aim at investigating whether hydroxychloroquine reduces the viral load from the respiratory specimen in patients ."
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"Early trials demonstrated that HCQ + azithromycin could reduce viral load significantly , resulting in significant absorption of pneumonia and reduced recovery time [ 38 , 39 ] ."
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"They concluded that hydroxychloroquine ( 500 mg / day ) and AZ ( 250 mg / day for 5 days ) successfully reduced the viral load ."
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"According to a very recently published clinical study from France , hydroxychloroquine can significantly reduce viral load in COVID-19 patients , and azithromycin can further enhance this effect [ 22 ] ."
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"A recent study suggested that hydroxychloroquine could significantly reduce the viral load [ 7 ] , but it was conducted in outpatients and a recent trial [ 10 ] performed in the ICU failed to demonstrate any benefit of lopinavir / ritonavir on clinical outcomes and viral load reduction ."
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"Initially , hydroxychloroquine and azithromycin have been repurposed to reduce viral load in COVID-19 patients [ 4 ] , but these drugs were shown less effective subsequently ."
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"It is estimated that the virus binds ACE2 at acidic pH since hydroxychloroquine reduces the viral load by making pH elevation ."
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"[ 10 ] In addition , hydroxychloroquine has been shown to significantly reduce viral load in nasopharyngeal swabs in 20 French patients with COVID-19 ."
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"It was also reported that the addition of azithromycin , along with hydroxychloroquine , more effectively reduced the viral load when administered patients [ 133 ] ."
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"[ 18 ] Another study conducted by Gautret et al. found that the use of HCQ reduced the viral load significantly in patients suffering from COVID-19 ."
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"In a small study , hydroxychloroquine significantly decreased the viral load in COVID-19 patients and the addition of azithromycin further enhanced the reduction in viral load [ 10 ] ."
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"French studies suggested that HCQ , mainly when used with azithromycin , could reduce the viral load and improve the outcome of patients infected with SARS-CoV-2 ."
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"Therefore , HCQ is promising to reduce viral load in COVID-19 patients that is further strengthened by addition of AZ ( Gautret et al ., 2020 ) ."
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"Preliminary results by Gautret et al. suggest that HCQ 600 mg daily may decrease viral load in nasal swabs [ 54 ] ; furthermore , Gao reports that `` chloroquine phosphate is superior to the control treatment in inhibiting the exacerbation of pneumonia , improving lung imaging findings , promoting a virus negative conversion , and shortening the disease course '' [ 55 ] ."
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"It has been reported that HCQ alone or in combination with azithromycin reduces viral load and accelerates the recovery of outpatients with mild symptoms of COVID-19 , but no effect on mortality could be observed [ 9 ] ."
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"Hydroxychloroquine reduced viral load in COVID-19 patients and Azithromycin in addition to Hydroxychloroquine reinforced its anti-viral potential and makes it more efficient in eliminating the virus [ 206 ] ."
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"RDV ( 12.5 muM ) and HCQ ( 10 muM ) reduced viral titre by 100 - and 10-fold , respectively ."
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"An open-label non-randomized clinical trial by Gauret et al. showed that HCQ reduces viral load in most COVID-19 patients and that its efficacy is enhanced in combination with azithromycin [ 11 ] ."
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"A nonrandomized 20 patient study showed that HCQ reduced the viral load , but it failed to correlate results with clinical outcomes , providing the basis for many centers ' adoption of this experimental therapy [ 20 ] ."
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"A recent study evaluating the in vivo effect of HCQ in Syrian hamster model of COVID-19 reported that HCQ did not reduce viral loads or affect viral transmission even when given at a high dose of 50 mg / kg / day ( Kaptein et al ., 2020 ) ."
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"Reduction of viral load by HCQ ."
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"In summary , while protease inhibitors may decrease viral burden , inhaled nitric oxide may reduce V / Q mismatch , anticytokine therapy may treat cytokine storm or prevent its progression , and immunomodulators like chloroquine / hydroxychloroquine may inhibit viral replication , RRx-001 may serve as an all-in-one therapy , which improves cardiopulmonary function , decreases viral burden and reduces the systemic inflammatory response ."
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"In addition , a recent study in SARS-CoV-2-infected cynomolgus macaques showed that HCQ alone or in combination with azithromycin did not result in a significant decrease in viral loads , both in a therapeutic and in a prophylactic setting ( 13 ) ."
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"[ 3435 ] A study by Gautret et al. showed that HCQ reduced the viral load significantly in SARS-CoV-2 infections ."
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"RDV ( 12.5 muM ) and HCQ ( 10 muM ) 270 reduced viral titre by 100-and 10-fold , respectively ."
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"In France , a clinical trial showed that HCQ significantly reduced viral load in patients infected with SARS-CoV-2 , especially when co-administered with azithromycin ( Gautret et al ., 2020a ) , which was supported by the conclusion of another study ( Gautret et al ., 2020b ) ."
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"Though , HCQ was reported to promote viral load reduction / disappearance in COVID-19 patients and the effect was reinforced by azithromycin , it is limited by the sample size ( Gautret , et al ., 2020a ) ."
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"A Phase 2 multi-center open-labeled randomized clinical trial is being conducted in Korea on 150 participants which aim at investigating whether hydroxychloroquine reduces the viral load from the respiratory specimen in patients ."
| PMC
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"The investigators concluded that HCQ , in conjunction with azithromycin , effectively reduces viral load in COVID-19 ."
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"47 These studies , including to date the largest RECOVERY trial , show that at the doses used , CQ or HCQ ( with or without AZM ) is not effective in reduction of viral load , post-exposure prophylaxis , improving survival or reducing the need for respiratory support in hospitalized patients ."
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"A study from France reported that hydroxychloroquine significantly reduces the viral load in patients with COVID-19 , and demonstrates synergistic interactions with azithromycin [ 9 ] ."
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"7 Recent open-labeled , nonrandomized clinical trials showed that HCQ may decrease viral load and may improve outcomes in a small number of patients with COVID-19 ."
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"Results revealed that hydroxychloroquine could significantly reduce the viral load and azithromycin could reinforce its clinical effect , but the main limitation of this clinical trial was its small sample size 42 ."
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"40 A pilot observational study from France demonstrated that HCQ reduced viral load in most COVID-19 patients and that its efficacy was enhanced in combination with azithromycin.41 HCQ could be administered early in the COVID-19 course to prevent the spread of the infection or in the late stages during the cytokine storm ."
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"Overall evaluation of the available evidence ( Table 1 ) shows that at the doses used , CQ or HCQ ( with or without AZM ) is not effective in reduction of viral load , post-exposure prophylaxis , improving survival or reducing the need for respiratory support in hospitalized patients ."
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"A non-randomized twenty patient study showed that hydroxychloroquine reduced viral load , but failed to correlate results with clinical outcomes , provided the basis for many centers ' adoption of this experimental therapy [ 19 ] ."
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"Other study suggested that Azithromycin plus Hydroxychloroquine may reduce viral load , nonetheless , the clinical response associated with this approach was not evaluated and remains to be defined [ 16 ] ."
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"Further , an open-label non-randomized clinical trial reported that HCQ caused a decline in the viral load in COVID-19 patients ."
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"CQ and HCQ may interfere with virus replication at the early stages of infection or increasing endosome-mediated pH at the viral entry / cell fusion , as well as post-translational modification of the glycosylation of cellular receptors of SARS-CoV-2.6 Along with this , Savarino et al suggested that CQ may reduce the level of inflammatory cytokines and could ameliorate acute respiratory distress syndrome.11 Recent preliminary clinical studies suggested that CQ and HCQ may be able to lower the COVID-19 viral load and reduce the duration of viremia ."
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