IndraLab

Statements

COPS5 inhibits CUL1. 3 / 3
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"Since the neddylated : non neddylated Cul1 ratio is higher than normal in csn5 null mutants and lower than normal in Int6 mutants, we reasoned that the csn5 null mutation should rescue the reduced Cul1 neddylation in Int6 mutants."
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"siRNA mediated CSN5 silencing was sufficient to disrupt the CSN complex, and induced Cullin 1 hyperneddylation which was paralleled by a decrease in free NEDD8 (XREF_FIG)."
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"Interestingly, we noticed that COPS5 recently was reported to inhibit Cullin1 neddylation (Cope et al., 2002; Muromoto et al., 2013)."
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