IndraLab

Statements

COPS5 inhibits CUL1. 4 / 4
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"Interestingly, we noticed that COPS5 recently was reported to inhibit Cullin1 neddylation (Cope et al., 2002; Muromoto et al., 2013)."
28583475
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"Importantly, JAB1 knockdown induced the activation of SCF ubiquitin ligase complex containing Cullin 1 (CUL1), as judged by the enhancement of covalent modification of CUL1 with the ubiquitin like protein NEDD8, and markedly reduced the basal protein level of IFNR."
24043623
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"Since the neddylated : non neddylated Cul1 ratio is higher than normal in csn5 null mutants and lower than normal in Int6 mutants, we reasoned that the csn5 null mutation should rescue the reduced Cul1 neddylation in Int6 mutants."
18493598
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"siRNA mediated CSN5 silencing was sufficient to disrupt the CSN complex, and induced Cullin 1 hyperneddylation which was paralleled by a decrease in free NEDD8 (XREF_FIG)."
21499307