IndraLab

Statements


USP14 binds b-AP15. 3 / 3
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"We found that binding of b-AP15 to USP14 is partially reversible, and that inhibition of proteasome function is reversible in cells."

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"Building upon this we also examined the binding of b-AP15 to USP14 in EWS cells using a cellular thermo stability assay (CETSA)."

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"In silico modelling identified protein residues that were critical for the binding of b-AP15 with USP14 or UCHL5 and proteasome enzyme activity assays confirmed that b-AP15 does not affect the proteolytic capabilities of the 20S proteasome beta-subunits."