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Knockout HDAC1 HDAC2 activates USP11. 3 / 3
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"f , i The knockout of both HDAC1 and HDAC2 upregulated USP11 at the mRNA and protein levels in U87-vIII , U251-vIII and N9-vIII cells performed and showed that USP11 expression was downregulated at the mRNA and protein levels in U87 , U251 and N9 cells upon the activation of EGFR-vIII ( Fig. 5c , d ) ."
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"The knockout of both HDAC1 and HDAC2 upregulated USP11 at the mRNA and protein levels in U87-vIII , U251-vIII and N9-vIII cells ( Fig. 5f , i ) ."
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"f , i The knockout of both HDAC1 and HDAC2 upregulated USP11 at the mRNA and protein levels in U87-vIII , U251-vIII and N9-vIII cells Fig. 6 : EGFR-vIII enhanced USP11 promoter silencing through downregulating H3K27AC and H2AZK4 / 7AC in the USP11 promoter area ."
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