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BRD4 binds USP17L2. 22 / 22
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"Given that JQ1 induces upregulation of DUB3 at both the mRNA and protein levels in different cell types ( Borbely et al., 2015 ) ( Figures 2 J–2M) and DUB3 binds to BRD4 and promotes its deubiquitinat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Given that the C-terminal region in three ubiquitously expressed BET proteins including BRD2, BRD3, and BRD4 is very much diversified and only BRD4 contains the C-terminal motif (CTM) ( xref ), we sought to investigate whether the interaction between BRD4 and DUB3 is specific."
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"CoIP assays revealed that while DUB3 bound to BRD4, it did not bind to BRD2 and BRD3 in PC-3 cells ( Figure 4 D)."
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"De-ubiquitinase DUB3 binds to BRD4, but not BRD2/3, via a specific C-terminal motif (CTM), antagonizes SPOP-mediated BRD4 ubiquitination, and promotes BRD4 de-ubiquitination and stabilization, leading to BET-BD inhibitor resistance in cancer cells (Jin et al., 2018)."
34540900
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"DUB3 binds to BRD4 and promotes its deubiquitination and stabilization."
30150556
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"Given that the C-terminal region in three ubiquitously expressed BET proteins, including BRD2, BRD3, and BRD4, is very much diversified and only BRD4 contains the C-terminal motif (CTM) ( Figure S4 A)[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"DUB3 binds to BRD4 and promotes its deubiquitination and stabilization."
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"Given that JQ1 induces upregulation of DUB3 at both mRNA and protein levels in different cell types ( xref ) ( xref ) and DUB3 binds to BRD4 and promotes its deubiquitination and protein stabilization ( xref and xref ), we sought to determine whether JQ1-induced stabilization of BRD4 is mediated through upregulation of active DUB3."
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"Interaction between endogenous BRD4 and DUB3 proteins was detected in PC-3 cells ( xref )."
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"We further demonstrated that BRD4-DUB3 interaction is mediated through the CTM motif in BRD4 ( xref )."
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"DUB3 specifically interacts with BRD4 in cells."
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"In the present study, we demonstrated that DUB3 specifically binds to BRD4 and promotes its deubiquitination."
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"Given that JQ1 induces upregulation of DUB3 at both the mRNA and protein levels in different cell types (Borbely et al., 2015) and DUB3 binds to BRD4 and promotes its deubiquitination and protein stab[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30057199
sparser
"De-ubiquitinase DUB3 binds to BRD4, but not BRD2/3, via a specific C-terminal motif (CTM), antagonizes SPOP-mediated BRD4 ubiquitination, and promotes BRD4 de-ubiquitination and stabilization, leading to BET-BD inhibitor resistance in cancer cells ( xref )."
34540900
reach
"Given that the C-terminal region in three ubiquitously expressed BET proteins, including BRD2, BRD3, and BRD4, is very much diversified and only BRD4 contains the C-terminal motif (CTM), we sought to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we demonstrate that the deubiquitinase DUB3 binds to BRD4 and promotes its deubiquitination and stabilization."
30057199
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"Interaction between endogenous BRD4 and DUB3 proteins was detected in PC-3 cells ( Figures 4 C and 4D)."
30057199
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"Co-IP assays revealed that while DUB3 bound to BRD4, it did not bind to BRD2 and BRD3 in PC-3 cells ( xref )."
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"CoIP assays revealed that while DUB3 bound to BRD4, it did not bind to BRD2 and BRD3 in PC-3 cells."
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"Co-IP assays revealed that the C-terminal end of BRD4 containing amino acids (aa) 1047-1362 interacted with DUB3 ( xref )."
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"We further found that BRD4-DUB3 interaction is mediated through the CTM motif in BRD4 ( Figure 4 I)."
30057199
sparser
"In the present study we demonstrated that DUB3 specifically binds to BRD4 and promotes its deubiquitination."
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