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USP17L2 binds BRD4. 23 / 26
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"On the other hand, deubiquitinase DUB3 can directly bind BRD4 and deubiquitinate it, leading to BRD4 stabilization and elevated levels of BRD4."
35866356
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"DUB3 binds to BRD4 and promotes its deubiquitination and stabilization."
30150556
sparser
"DUB3 binds to BRD4 and promotes its deubiquitination and stabilization."
30150556
reach
"Castration-resistant prostate cancer cells with high levels of the deubiquitinase DUB3 and NUT midline carcinoma cells with high levels of KLF4 are resistant to BRD4 inhibitors, because DUB3 binds to BRD4 and augments its deubiquitination and stabilization and KLF4 up-regulates E2F and MYC gene expression [45, 46]."
38135679
sparser
"Here, we demonstrate that the deubiquitinase DUB3 binds to BRD4 and promotes its deubiquitination and stabilization."
30057199
sparser
"On the other hand, deubiquitinase DUB3 can directly bind BRD4 and deubiquitinate it, leading to BRD4 stabilization and elevated levels of BRD4."
35866356
sparser
"DUB3 specifically interacts with BRD4 in cells."
30057199
sparser
"Interaction between endogenous BRD4 and DUB3 proteins was detected in PC-3 cells ( xref )."
30057199
sparser
"Co-IP assays revealed that the C-terminal end of BRD4 containing amino acids (aa) 1047-1362 interacted with DUB3 ( xref )."
30057199
sparser
"Given that the C-terminal region in three ubiquitously expressed BET proteins including BRD2, BRD3, and BRD4 is very much diversified and only BRD4 contains the C-terminal motif (CTM) ( xref ), we sought to investigate whether the interaction between BRD4 and DUB3 is specific."
30057199
sparser
"Co-IP assays revealed that while DUB3 bound to BRD4, it did not bind to BRD2 and BRD3 in PC-3 cells ( xref )."
30057199
sparser
"We further demonstrated that BRD4-DUB3 interaction is mediated through the CTM motif in BRD4 ( xref )."
30057199
sparser
"Given that JQ1 induces upregulation of DUB3 at both mRNA and protein levels in different cell types ( xref ) ( xref ) and DUB3 binds to BRD4 and promotes its deubiquitination and protein stabilization ( xref and xref ), we sought to determine whether JQ1-induced stabilization of BRD4 is mediated through upregulation of active DUB3."
30057199
sparser
"In the present study we demonstrated that DUB3 specifically binds to BRD4 and promotes its deubiquitination."
30057199
sparser
"Castration-resistant prostate cancer cells with high levels of the deubiquitinase DUB3 and NUT midline carcinoma cells with high levels of KLF4 are resistant to BRD4 inhibitors, because DUB3 binds to BRD4 and augments its deubiquitination and stabilization and KLF4 up-regulates E2F and MYC gene expression [ xref , xref ]."
38135679
sparser
"DUB3 binds to BRD4 protein and promotes its deubiquitination and stabilization."
38893083
sparser
"De-ubiquitinase DUB3 binds to BRD4, but not BRD2/3, via a specific C-terminal motif (CTM), antagonizes SPOP-mediated BRD4 ubiquitination, and promotes BRD4 de-ubiquitination and stabilization, leading to BET-BD inhibitor resistance in cancer cells ( xref )."
34540900
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"DUB3 binds to BRD4 protein and promotes its deubiquitination and stabilization."
38893083
reach
"Given that the C-terminal region in three ubiquitously expressed BET proteins, including BRD2, BRD3, and BRD4, is very much diversified and only BRD4 contains the C-terminal motif (CTM), we sought to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30057199
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"De-ubiquitinase DUB3 binds to BRD4, but not BRD2/3, via a specific C-terminal motif (CTM), antagonizes SPOP-mediated BRD4 ubiquitination, and promotes BRD4 de-ubiquitination and stabilization, leading to BET-BD inhibitor resistance in cancer cells (Jin et al., 2018)."
34540900
reach
"CoIP assays revealed that while DUB3 bound to BRD4, it did not bind to BRD2 and BRD3 in PC-3 cells."
30057199
reach
"Given that JQ1 induces upregulation of DUB3 at both the mRNA and protein levels in different cell types (Borbely et al., 2015) and DUB3 binds to BRD4 and promotes its deubiquitination and protein stab[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30057199
reach
"In the present study, we demonstrated that DUB3 specifically binds to BRD4 and promotes its deubiquitination."
30057199