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Phosphorylated AKT activates MTOR. 59 / 59
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"In addition, p-Akt can activate downstream mTOR protein, caspase-9 cleavage, as well as the action of transcription factors related to cell survival ( Revathidevi and Munirajan, 2019 )."
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"Mammalian target of rapamycin (mTOR) is the downstream target of AKT, and can be activated by p-AKT to regulate cell growth and division, maintain metabolism, and control protein synthesis."
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"P-Akt has also been shown to promote cell proliferation by regulating the stability of cyclin D1 or activating mTOR."
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"As p-Akt in turn activates mTOR, we next analyzed the activity of mTOR by studying the phosphorylation of Raptor."
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"Thereafter, phosphorylated Akt activates mTOR, resulting in phosphorylation of ribosomal protein S6 kinase (p70S6K) and the 4E-binding protein 1 (4E-BP1), which promotes protein synthesis by activating ribosomal protein S6 and releasing eukaryotic translation initiation factor eIF-4E, respectively."
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"In addition, p-Akt can activate downstream mTOR protein, caspase-9 cleavage, as well as the action of transcription factors related to cell survival ( Revathidevi and Munirajan, 2019 )."
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"These results indicated that the phosphorylation of Akt induced mTOR activation and led to the phosphorylation of p70S6k and 4E-BP1."
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"MTOR, a major intracellular repressor of autophagy, could be activated by p-Akt, as judged by activation of phosphorylated mTOR (p-mTOR)."
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"Notably, in the mTOR pathway AKT phosphorylation leads to mTOR pathway activation and ultimately S6 phosphorylation."
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"In specific, curcumin downregulated the levels of p-AKT, total AKT, p-mTOR, and PI3Kp85, as well as the phosphorylated form, suggesting that it promotes mTOR-dependent autophagic cell death in these GBM cell lines [57,98]."
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"The mTOR activity is mediated by p-AKT."
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"As phosphorylated Akt activates mTOR and its downstream target p70S6K, we also observed the expression of p-mTOR (78.3%, 48.1%) and p-p70S6K (76.1%, 54.1%) according to the expectation."
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"It is known that phosphorylated Akt activates mTOR and NF-κB, and mTOR is upstream of 4EBP1 and NF-kB is upstream of Cox2."
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"In addition, it is shown that ASXL1‐MT cooperates with BAP1 to promote the deubiquitylation and stabilization of phosphorylated AKT, which leads to the activation of the AKT/mTOR pathway [32]."
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"The combination of chidamide and orelabrutinib substantially reduced p-AKT levels, consequently augmenting mTOR pathway suppression."
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"Under the regulation of upstream factors , PI3K phosphorylates PIP2 to PIP3 , and PIP3 promotes the binding of AKT to the cell membrane ; PDK phosphorylates AKT to p-AKT , which indirectly activates mTOR ."
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"Phosphorylated AKT (p-AKT) could directly activate the mTOR signaling pathway or indirectly activate the mTOR signaling pathway by inhibiting tuberous sclerosis complex 1/2 (TSC1/2) (77, 78)."
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"The phosphorylated Akt activated mTOR via the TSC-Rbeb axis XREF_BIBR, and the decreased mTOR activity in SCs in exercise mice could be attributed to reduced total Akt and phosphorylated Akt."
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"MTOR complex 1 (mTORC1), which is activated by fully phosphorylated AKT, is one of the key targets within this signaling pathway [12]."
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"Phosphorylated AKT (p-AKT) could directly activate the mTOR signaling pathway or indirectly activate the mTOR signaling pathway by inhibiting tuberous sclerosis complex 1/2 (TSC1/2) (77, 78)."
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"Phosphorylated AKT is known to activate mTOR, which can stimulate glutamine utilization 50, and increases in glutamine concentration can directly modulate the mTOR pathway 51."
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"P-AKT (phosphorylated AKT) can activate mTOR by inhibiting TSC2 and TSC."
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"P-AKT activates mTOR, and cell metabolism is subsequently regulated, such as in the inhibition of apoptosis ( Moschetta et al., 2014 )."
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"The phosphorylated Akt in turn activates the oncogenic mTOR complex 1 (mTORC1) through inhibition of TSC1/2, which are negative regulators of mTOR."
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"Phosphorylated Akt can activate mTOR and mTOR inhibits downstream molecule ULK1 complex to negatively regulate autophagy."
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"Silencing FAM83D reduced the expression of p-AKT/AKT and p-mTOR/mTOR, while its overexpression caused the opposite changes, inactivating the AKT/mTOR signaling pathway in glioma by silencing FAM83D."
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"Western blot analysis confirmed up-regulation of mTOR downstream signaling including PI3K, p-Akt, p-mTOR, and p-P70S6K (XREF_FIG)."
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"In the pathway, phosphorylated AKT, which is the core of the pathway, translocates to the cell membrane and activates mTOR [99]."
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"Curcumin administration also significantly increased the levels of phosphorylated-ERK1/2 (p-ERK1/2) and decreased levels of p-Akt, indicating that curcumin promotes ERK1/2 pathway activation and inhibits Akt/mTOR pathway activation in the injured sciatic nerve."
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"P-AKT activates mTOR, and cell metabolism is subsequently regulated, such as in the inhibition of apoptosis ( Moschetta et al., 2014 )."
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"The overexpression of RASD1 reduced the phosphorylation of p-Akt, p-S6 and p-GSK3beta, which finally inactivated the Akt and mTOR pathway."
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"MTOR, a major intracellular repressor of autophagy, could be activated by p-Akt, as judged by activation of phosphorylated mTOR (p-mTOR)."
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"Following PI3K activation, AKT is phosphorylated and p-AKT can subsequently activate the mechanistic target of rapamycin (mTOR) through direct or indirect interactions, and activated mTOR (p-mTOR) can then regulate cell growth, proliferation, motility, and survival ( xref )."
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"P-AKT activates downstream mTOR signaling by direct phosphorylation of the Ser2448 of mTOR or by inhibition of nodular sclerosis complex (TSC)2 to form a complex with TSC1."
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"Considering that mTOR is activated by p-Akt downstream of PI3K, it is likely that the administration of rapamycin would control the protozoan induced apoptosis of endothelial cells and thus block the movement of parasites into the brain."
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"In particular, phosphorylated Akt activates mTOR, which negatively regulates autophagy by inhibiting the downstream molecule ULK1 complex."
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"Phosphorylated AKT triggers mTOR and attenuates apoptotic factors such as glycogen synthase kinase 3 β (GSK3β) [156]."
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"There is evidence for PI3K activation in the lungs and cells of COPD patients, as shown by increased expression of the downstream kinase phosphorylated Akt, which in turn activates mTOR [36]."
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"AdIGFBPrP1 treatment reduced p-Akt and p-mTOR levels, which indicated that IGFBPrP1 might promote HSCs activation by mediating the phosphorylation of Akt and mTOR and reducing the upstream kinase activity of mTOR to inhibit autophagy."
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"Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1 and PD-L1 axis activating intracellular AKT and mTOR pathway in tumor cells."
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"Considering that mTOR is activated by p-Akt downstream of PI3K, it is likely that the administration of rapamycin would control the protozoan induced apoptosis of endothelial cells and thus block the movement of parasites into the brain."
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"This in turn leads to the phosphorylation and activation of AKT, and phosphorylated AKT activates mTOR, which further activates p70S6K which plays an essential role in the G1 to S phase progression [106–108]."
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"KS lesions almost universally exhibit phosphorylated Akt, which activates mTOR kinase and phosphorylated S6, which is a biomarker for mTOR kinase activity."
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"Furthermore, miR-410 overexpression increased p-AKT and p-mTOR protein expression, which was attenuated by PTEN overexpression in SH-SY5Y and PC12 cells, suggesting that miR-410 activates the AKT/mTOR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Under the regulation of upstream factors, PI3K phosphorylates PIP2 to PIP3, and PIP3 promotes the binding of AKT to the cell membrane; PDK phosphorylates AKT to p-AKT, which indirectly activates mTOR."
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"miR-520a-3p may decrease the AKT and p-AKT expressions by inhibition of AKT1 transcription to inhibit the activation of the AKT and mTOR pathway."
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"In cortical neurons, silencing of PKM2 upregulates p-AKT expression ( Wu et al., 2019 ) which is known to activate the mTOR complex 1 (mTORC1) to inhibit autophagy and mitophagy ( Heras-Sandoval et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Through inhibition of phosphorylated AKT and downstream activation of mTOR, overexpressed BCYRN1 significantly increased the expression of LC3-II and Beclin-1, both of which can reflect the process of autophagy."
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"The results suggest that IER3 can inhibit the phosphorylation of AKT and mTOR, and in the autophagy pathway, phosphorylated AKT activated the mTOR pathway and then inhibited the occurrence of autophagy."
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"Ursolic acid dramatically inhibited the expression of p-AKT and p-mTOR indicating that ursolic acid downregulate the AKT/mTOR pathway to turn on autophagy."
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"As p-Akt in turn activates mTOR, we next analyzed the activity of mTOR by studying the phosphorylation of Raptor."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR Phosphorylated Akt activated mTOR complexes, which in turn downregulated autophagy."
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"Following PI3K activation, AKT is phosphorylated, and p-AKT subsequently activates the mTOR, regulating cell growth, proliferation, motility, and survival (Zhang and Fan xref )."
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"The phosphorylated AKT then activates the downstream mTOR to initiate autophagy."
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"Phosphorylated AKT activates its downstream target mammalian target of rapamycin (mTOR), successively, mTOR regulates its downstream effector ribosomal S6-kinase (p70S6K) and 4E-BP-1, thus controls ce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recent studies have confirmed our results, showing that p-Akt Ser473 is able to activate mTOR in hematopoietic stem cell aging by phosphorylation of Ser2448, leading to an increase of down-stream p-p70S6K Thr389."
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"A downstream serine/threonine protein kinase, a mammalian target of rapamycin (mTOR), is also activated by p-AKT, which is an important regulator of cell growth, proliferation, and apoptosis."
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"P-AKT (phosphorylated AKT) can activate mTOR by inhibiting TSC2 and TSC."
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"P-AKT may further activate the mTOR and P70S6K signaling pathway, increase the expression of p-P70S6K and increase proliferation and migration of PASMCs."
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