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Phosphorylated AKT activates MTOR. 29 / 29
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"There is evidence for PI3K activation in the lungs and cells of COPD patients, as shown by increased expression of the downstream kinase phosphorylated Akt, which in turn activates mTOR [36]."
30181485
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"Through inhibition of phosphorylated AKT and downstream activation of mTOR, overexpressed BCYRN1 significantly increased the expression of LC3-II and Beclin-1, both of which can reflect the process of autophagy."
33391513
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"The overexpression of RASD1 reduced the phosphorylation of p-Akt, p-S6 and p-GSK3beta, which finally inactivated the Akt and mTOR pathway."
33255991
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"XREF_BIBR, XREF_BIBR, XREF_BIBR Phosphorylated Akt activated mTOR complexes, which in turn downregulated autophagy."
27695292
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"Recent studies have confirmed our results, showing that p-Akt Ser473 is able to activate mTOR in hematopoietic stem cell aging by phosphorylation of Ser2448, leading to an increase of down-stream p-p70S6K Thr389."
27004051
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"Phosphorylated Akt can activate mTOR and mTOR inhibits downstream molecule ULK1 complex to negatively regulate autophagy."
30906434
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"P-AKT (phosphorylated AKT) can activate mTOR by inhibiting TSC2 and TSC."
30832706
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"The mTOR activity is mediated by p-AKT."
28005970
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"Following PI3K activation, AKT is phosphorylated, and p-AKT subsequently activates the mTOR, regulating cell growth, proliferation, motility, and survival (Zhang and Fan xref )."
35175172
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"Considering that mTOR is activated by p-Akt downstream of PI3K, it is likely that the administration of rapamycin would control the protozoan induced apoptosis of endothelial cells and thus block the movement of parasites into the brain."
29162126
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"Phosphorylated AKT is known to activate mTOR, which can stimulate glutamine utilization 50, and increases in glutamine concentration can directly modulate the mTOR pathway 51."
29170516
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"miR-520a-3p may decrease the AKT and p-AKT expressions by inhibition of AKT1 transcription to inhibit the activation of the AKT and mTOR pathway."
28653601
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"These results indicated that the phosphorylation of Akt induced mTOR activation and led to the phosphorylation of p70S6k and 4E-BP1."
30813318
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"Under the regulation of upstream factors, PI3K phosphorylates PIP2 to PIP3, and PIP3 promotes the binding of AKT to the cell membrane; PDK phosphorylates AKT to p-AKT, which indirectly activates mTOR."
31239864
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"The phosphorylated Akt activated mTOR via the TSC-Rbeb axis XREF_BIBR, and the decreased mTOR activity in SCs in exercise mice could be attributed to reduced total Akt and phosphorylated Akt."
32483463
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"Considering that mTOR is activated by p-Akt downstream of PI3K, it is likely that the administration of rapamycin would control the protozoan induced apoptosis of endothelial cells and thus block the movement of parasites into the brain."
29162126
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"Western blot analysis confirmed up-regulation of mTOR downstream signaling including PI3K, p-Akt, p-mTOR, and p-P70S6K (XREF_FIG)."
25534817
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"Following PI3K activation, AKT is phosphorylated and p-AKT can subsequently activate the mechanistic target of rapamycin (mTOR) through direct or indirect interactions, and activated mTOR (p-mTOR) can then regulate cell growth, proliferation, motility, and survival ( xref )."
28852437
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"P-AKT may further activate the mTOR and P70S6K signaling pathway, increase the expression of p-P70S6K and increase proliferation and migration of PASMCs."
28656233
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"P-Akt has also been shown to promote cell proliferation by regulating the stability of cyclin D1 or activating mTOR."
25013474
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"P-AKT (phosphorylated AKT) can activate mTOR by inhibiting TSC2 and TSC."
30832706
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"Ursolic acid dramatically inhibited the expression of p-AKT and p-mTOR indicating that ursolic acid downregulate the AKT/mTOR pathway to turn on autophagy."
31547522
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"KS lesions almost universally exhibit phosphorylated Akt, which activates mTOR kinase and phosphorylated S6, which is a biomarker for mTOR kinase activity."
22529843
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"A downstream serine/threonine protein kinase, a mammalian target of rapamycin (mTOR), is also activated by p-AKT, which is an important regulator of cell growth, proliferation, and apoptosis."
35408483
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"Co-expression of PD-L1 and p-AKT is associated with poor prognosis in diffuse large B-cell lymphoma via PD-1 and PD-L1 axis activating intracellular AKT and mTOR pathway in tumor cells."
27147575
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"As p-Akt in turn activates mTOR, we next analyzed the activity of mTOR by studying the phosphorylation of Raptor."
29062100
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"As p-Akt in turn activates mTOR, we next analyzed the activity of mTOR by studying the phosphorylation of Raptor."
29062100
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"As phosphorylated Akt activates mTOR and its downstream target p70S6K, we also observed the expression of p-mTOR (78.3%, 48.1%) and p-p70S6K (76.1%, 54.1%) according to the expectation."
30087714
eidos
"Under the regulation of upstream factors , PI3K phosphorylates PIP2 to PIP3 , and PIP3 promotes the binding of AKT to the cell membrane ; PDK phosphorylates AKT to p-AKT , which indirectly activates mTOR ."
31239864