IndraLab

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COPS5 activates cell cycle. 19 / 19
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"Dysregulation of COPS5 activity has been shown to contribute to oncogenesis through its function in cell proliferation [XREF_BIBR], cell cycle progression [XREF_BIBR], and cell chemo- and radio-resistance [XREF_BIBR, XREF_BIBR], that are mediated by the various target molecules such as MDM2, p27, HIF-1alpha, and AP-1 [XREF_BIBR]."
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"Jab1/CSN5 silencing may arrest cell cycle progression and inhibit invasion via decreasing the transcriptional activity of NF-κB in colorectal cancer ."
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"Moreover, we revealed that the PI3K/Akt signaling pathway is responsible for CSN5-mediated tumor cell proliferation and cell cycle progression in OS."
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"In contrast, Jab1 does not synergize with E2F1 to promote cell cycle entry."
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"To examine whether the defect of cell cycle progression induced by CSN5/Jab1-depletin is mediated by the p53 pathway, we crossed CSN5/Jab1 −/f mice with p53 knockout mice and eventually isolated MEFs [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In conclusion, we propose that CSN5/Jab1 is a modulator of the mammalian cell cycle (somatic cell cycle/endocycle/senescence)."
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"We found that the knockdown of CSN5 significantly suppressed cell proliferation and cell cycle progression ( Fig. 2 G and I)."
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"These results suggest that CSN5 promotes NSCLC cell proliferation by facilitating cell cycle progression and inhibiting cell apoptosis.To further investigate whether CSN5 silencing could affect tumor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A conditional knockout of Csn5 in T cells inhibited cell cycle and led to an increase of β-catenin [45] ."
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"Additionally, our findings further demonstrate that silencing CSN5 arrested the cell cycle in G0/G1 phase and induced NSCLC cell apoptosis, indicating that CSN5 promotes NSCLC cell growth may be assoc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CSN5 silencing inhibits invasion and arrests cell cycle progression in human colorectal cancer SW480 and LS174T cells in vitro."
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"Additionally, Jab1/CSN5 silencing may arrest cell cycle progression and inhibit invasion via the PI3K/AKT/NF-κB signaling pathway in CRC ."
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"Jab1 (Jun activation domain binding protein 1), integrated into COP9 signalosome complex (CSN), induces protein instability of many tumor suppressors and cell cycle regulators and is therefore a novel target in cancer therapy."
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"Zhong G, Li H, Shan T, Zhang N. CSN5 silencing inhibits invasion and arrests cell cycle progression in human colorectal cancer SW480 and LS174T cells in vitro."
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"Our results show that CSN5 knockdown by small interfering (si) RNA caused a strong induction of apoptosis and inhibition of cell cycle progression in HCC cells in vitro."
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"Because Jab1 and CSN5 directly interacts with p27 and promotes p27 degradation in the cytoplasm, Jab1 and CSN5 promotes cell cycle progression [24]."
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"The Jab1/COPS5-related genes screened in GEPIA2 and STRING were subjected to GO and KEGG enrichment analysis, and KEGG results showed that Jab1/COPS5-related genes were enriched in ubiquitin mediated proteolysis and cell cycle (Figure 7E)."
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"As Jab1 modulates the cell cycle in other cell types, we investigated Schwann cell number, survival, and cell cycle progression in Jab1 -/- nerves."
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"On the contrary, Jab1/Csn5 [151] and Hes1 effector of the Notch signaling [152] act as p57KIP2 transcription inhibitors and promote the cell cycle progression."
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