IndraLab

Statements

COPS5 activates cell cycle. 10 / 10
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"In contrast, Jab1 does not synergize with E2F1 to promote cell cycle entry."
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"Our group recently found that Jab1 contributes to NPC tumorigenesis and resistance to radiotherapy by promoting NPC cell growth, dysregulating NPC cell cycle progression, and inhibiting radiation induced apoptosis XREF_BIBR, XREF_BIBR, XREF_BIBR."
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"As Jab1 modulates the cell cycle in other cell types, we investigated Schwann cell number, survival, and cell cycle progression in Jab1 -/- nerves."
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"Jab1 (Jun activation domain binding protein 1), integrated into COP9 signalosome complex (CSN), induces protein instability of many tumor suppressors and cell cycle regulators and is therefore a novel target in cancer therapy."
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"Dysregulation of COPS5 activity has been shown to contribute to oncogenesis through its function in cell proliferation [XREF_BIBR], cell cycle progression [XREF_BIBR], and cell chemo- and radio-resistance [XREF_BIBR, XREF_BIBR], that are mediated by the various target molecules such as MDM2, p27, HIF-1alpha, and AP-1 [XREF_BIBR]."
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"The knockdown of JAB1 impairs cell cycle progression , increases apoptosis , and its overexpression in human osteosarcoma is correlated with poor prognosis ."
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"We also found that knockdown of CSN5 remarkably suppressed cell growth by inducing cell cycle arrest and apoptosis promotion in NSCLC cells."
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"CSN5 silencing inhibits invasion and arrests cell cycle progression in human colorectal cancer SW480 and LS174T cells in vitro."
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"Because Jab1 and CSN5 directly interacts with p27 and promotes p27 degradation in the cytoplasm, Jab1 and CSN5 promotes cell cycle progression [24]."
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"Our results show that CSN5 knockdown by small interfering (si) RNA caused a strong induction of apoptosis and inhibition of cell cycle progression in HCC cells in vitro."
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