IndraLab

Statements

ASF1A binds PAN2. 19 / 19
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"To gain further support of the in vivo interaction between ASF1A and USP52, protein fractionation experiments with FLAG-ASF1A affinity eluates were carried out."
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"These results support the observation that ASF1A is physically associated with USP52 in vivo and suggest that ASF1A interacts with USP52 in cytoplasm."
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"Collectively, these results indicate that ASF1A interacts with USP52 through the N-terminal region of ASF1A and the WD40 repeat domain of USP52."
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"In addition, the interaction of USP52 and ASF1A further promotes the assembly of chromatin and cell cycle progress [ 16 ]."
37328395
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"Corroborating with the finding that WD40 repeat domain is required for the physical association of USP52 with ASF1A, expression of USP52 lacking WD40 repeat domain (USP52/ΔWD40) did not affect the level of ubiquitinated ASF1A species (Supplementary Fig.  xref )."
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"In addition, the interaction of USP52 and ASF1A further promotes the assembly of chromatin and cell cycle progress [ 16 ]."
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"In vivo deubiquitination assays showed an evident decrease in the polyubiquitination level of all ASF1A mutants except for K129R (Fig.  xref and Supplementary Fig.  xref ), while the association of USP52 with all ASF1A mutants was comparable to that of USP52 with wild-type ASF1A (Supplementary Fig.  xref )."
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"Moreover, the reduction in ASF1A protein level associated with USP52 depletion was probably through a proteasome-mediated protein degradation mechanism, as the effect could be effectively blocked by a proteasome specific inhibitor, MG132 (Fig.  xref )."
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"Consistently, the physical association of USP52 with ASF1A was detected primarily in the S phase of the cell cycle (Fig.  xref )."
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"Collectively, these observations suggest that USP52-promoted ASF1A stabilization is potentially associated with breast carcinogenesis."
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"Immunoprecipitation analysis revealed that USP52 is preferentially associated with ASF1A in the S phase of the cell cycle, when ASF1A transfers H3.1–H4 dimer to replicating chromatin."
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"These results support the observation that ASF1A is physically associated with USP52 in vivo and suggest that ASF1A interacts with USP52 in cytoplasm."
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"Our findings suggest that inhibition of the enzymatic activity of USP52 or disruption of the association of USP52 with ASF1A, combined with chemo- or radio-therapy, could potentially improve the treatment of breast cancer."
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"Collectively, these results indicate that ASF1A interacts with USP52 through the N-terminal region of ASF1A and the WD40 repeat domain of USP52."
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No evidence text available
28514442
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"Here we report that ASF1A is physically associated with USP52, which is previously identified as a pseudo-deubiquitinase."
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No evidence text available
33961781
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"Histone chaperone ASF1A is physically associated with USP52."
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"To confirm the in vivo association of ASF1A with USP52, co-immunoprecipitation experiments were performed and the results showed that USP52 was efficiently co-immunoprecipitated with ASF1A, and vice versa (Fig.  xref )."
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