IndraLab

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USP18 inhibits Infections. 4 / 4
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"A partial form of inherited human USP18 deficiency underlies infection and inflammation."
35258551
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"Therefore, these results suggested that inhibiting the expression of IFIT3, OASL, USP18, XAF1, IFI27, and EPSTI1 may reduce the risk of SARS‐CoV‐2 infection and may also have a positive effect on antiviral therapy in patients with SARS‐CoV‐2 infection.In conclusion, this study comprehensively analyzed the blood leukocytes gene expression profile data of COVID‐19 patients by using bioinformatics methods and provided a preliminary understanding of the functions and mechanisms of DEGs in the leukocytes of COVID‐19 patients."
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"Therefore, these results suggested that inhibiting the expression of IFIT3, OASL, USP18, XAF1, IFI27, and EPSTI1 may reduce the risk of SARS-CoV-2 infection and may also have a positive effect on antiviral therapy in patients with SARS-CoV-2 infection.and 4G)."
34009691
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"This will also induce the expression of USP18, an inhibitor of the IFN signaling pathway, leading to an impaired antiviral state and to an increased propensity to develop chronic infection."
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