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USP18 inhibits Infections. 3 / 3
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"Therefore, these results suggested that inhibiting the expression of IFIT3, OASL, USP18, XAF1, IFI27, and EPSTI1 may reduce the risk of SARS‐CoV‐2 infection and may also have a positive effect on antiviral therapy in patients with SARS‐CoV‐2 infection.In conclusion, this study comprehensively analyzed the blood leukocytes gene expression profile data of COVID‐19 patients by using bioinformatics methods and provided a preliminary understanding of the functions and mechanisms of DEGs in the leukocytes of COVID‐19 patients."
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"A partial form of inherited human USP18 deficiency underlies infection and inflammation."
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"For example, silencing USP18 has been shown to promote the antiviral innate immunity against hepatitis C virus infection [52], while pharmacological inhibition of USP14 greatly suppresses murine norovirus infection [53]."
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