IndraLab

Statements

CHEK2 phosphorylates TP53 on S15. 23 / 23
1 4 | 12 6
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"The DNA damage response manifested itself by H2AX phosphorylation, ATM and Chk2 activation and phosphorylation of p53 on Ser15."
19373929
sparser
"For instance, the DNA damage insult mediates phosphorylation of p53 at Ser15 and Ser20 by ATM, ATR, DNA-PK, Chk1, and Chk2, resulting in an increase of transcriptional activity of p53 [ xref , xref , xref ]."
32660118
signor
"Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability. We have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53."
17339337
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"After DNA damage, ATM and CHK2 phosphorylate p53 (S15 and S20), thus reducing its ability to bind MDM2 and contributing to its stabilization [XREF_BIBR, XREF_BIBR]."
27258263
signor
"Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53."
10656682
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"Phosphorylation of p53 at Ser 15 by ATM and at Ser 20 by Chk2 inhibits p53 degradation by MDM2, a RING finger E3 ligase which ubiquitinates and degrades p53 through ubiquitin mediated proteolysis."
20183804
signor
"Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53."
10673501
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"In contrast to cdc25a, p53 is phosphorylated by Chk2 at sites Ser 15 and 20, stabilizing p53 expression and leading to enhanced transcriptional activity [ xref ]."
20514219
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"Importantly, Chel A induced p53 protein expression was blocked in Chk2-/- cells, and the phosphorylation of p53 at Ser20 and Ser15 were almost abrogated by Chk2 knockout."
24553354
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"Whereas CHK1 inbibits the CDC25 phosphatase, inducing phosphorylation and inactivation of G2 CDKs, ATM and CHK2 phosphorylate p53 at Ser 15 in the N-terminal transcriptional activation domain."
24561200
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"CHK2 phosphorylates tumor inhibitor p53 at the ser15 and ser20 residues, leading to its stabilization and activation, finally resulting in cell cycle arrest (Ou et al., xref )."
36177479
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"N-terminal phosphorylation of p53 at serine residues S15 and S20 by ATM, ATR, CHK1 and CHK2, and other kinases stabilizes and activates p53 [XREF_BIBR, XREF_BIBR]."
29963241
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"In contrast to Cdc25A, p53 is phosphorylated not only by Chk1 and Chk2 (on Thr18, Ser20, and possibly other residues) but also directly by the upstream checkpoint kinases ATM and ATR, particularly, on[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15279786
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"Phosphorylation of p53 at Ser15 is mediated by ATM and CHK2 in response to DNA damage [XREF_BIBR]."
26733491
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"WIP1 also dephosphorylates and inactivates the p53-activating kinases ATM, CHK1 and CHK2, which phosphorylate p53 at Ser15 and Ser20, respectively [ xref , xref , xref , xref , xref ]."
| PMC
biopax:phosphositeplus
No evidence text available
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"In contrast to cdc25a, p53 is phosphorylated by Chk2 at sites Ser 15 and 20, stabilizing p53 expression and leading to enhanced transcriptional activity [XREF_BIBR]."
20514219
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"This activation allows phosphorylation of p53 on ser15 by CHK2, which leads to the activation of REDD1 46, which is responsible for melanoma cell death."
33431809
signor
"Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53."
10710310
sparser
"In addition to the direct phosphorylation of p53 on Ser 15 by Chk2, xref , xref - xref ATM and Chk2 may indirectly contribute to p53 activation through phosphorylation of MDMX. xref "
18802408
reach
"After DNA damage, ATM and CHK2 phosphorylate p53 (S15 and S20), thus reducing its ability to bind MDM2 and contributing to its stabilization [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25247188
reach
"P53 S15 phosphorylation is mainly mediated by ATM or CHK2, two prominent kinases in DNA damage response [XREF_BIBR - XREF_BIBR]."
26042776
sparser
"This activation allows phosphorylation of p53 on ser15 by CHK2, which leads to the activation of REDD1 xref , which is responsible for melanoma cell death."
33431809