IndraLab

Statements

PSMD14 activates osteoclast differentiation. 3 / 3
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"As an endopeptidase, RPN11 functions to cleave polyubiquitin chains from substrates [126] While CSN5/Jab1 hydrolyzes the ubiquitin-like modifier Nedd8 [127], POH1 enhances osteoclast differentiation and RANKL signaling via regulating Mitf, an important regulator of osteoclast differentiation which required gene expression [128]."
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"Furthermore, de-ubiquitinase POH1 increased osteoclast differentiation ."
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eidos
"As an endopeptidase , RPN11 functions to cleave polyubiquitin chains from substrates [ 126 ] While CSN5 / Jab1 hydrolyzes the ubiquitin-like modifier Nedd8 [ 127 ] , POH1 enhances osteoclast differentiation and RANKL signaling via regulating Mitf , an important regulator of osteoclast differentiation which required gene expression [ 128 ] ."
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