IndraLab

"Mechanistically, MYC was shown to bind to the promoters of CD47 and PD-L1 as measured by chromatin immune-precipitation followed by sequencing (ChIP-Seq) [ xref ]."

"Oncogenic levels of MYC bound the CD47 and PD-L1 gene promoters in human osteosarcoma U2OS cells, whereas low levels of MYC did not ( xref )."

"Evasion of phagocytosis by myeloma cells can be achieved when PD-1 and SIRP-α anti-phagocytic receptors on the macrophage cell surface bind PD-L1 and CD47 ligands present on the MM cells, respectively xref , xref ( xref ))."

"Several other IgG-based CD47-targeting bispecific antibodies have been developed, among others CD20-CD47 [ xref ] and CD70-KWAR23 [ xref ] CD47-CD19 [ xref , xref ], CD47-MSLN [ xref ], CD47-PDL1 [ xref , xref ], and PD-L1-SIRPα [ xref ]."

"The TIS granules can promote the association between the SET protein and membrane proteins to be translated, such as CD47 and PD-L1, through a mechanism that the 3 -UTRs of the mRNAs of the membrane proteins facilitate the interaction between SET and CD47 or PD-L1."

"cMYC, a target of the canonical WNT pathway binds the promoters of the CD47 and PD-L1 genes."

"We applied ChIP (Chromatin ImmunoPrecipitation)-Seq analysis to mouse MYC T-ALL cells ( xref ) and the human B cell line P493-6 ( xref , xref ) and found high levels of MYC bound to the promoter regions of the genes coding for CD47 and PD-L1 ( xref , xref )."

"The variable-domain from the PD-L1-blocking mAb #18 (CN Patent: 201810952740.3) was introduced in tandem onto h4C1 to generate a dual variable domain bsAb that binds bivalently to both CD47 and PD-L1 ( xref )."

"Casey et al revealed that the MYC oncogene can regulate the antitumor immune response by directly binding to the promoters of the CD47 and programmed death ligand 1 (PD-L1) genes. xref Interleukin (IL)-6 has been demonstrated to upregulate CD47 expression on hepatoma cells by activating the signal transducer and activator of transcription 3 (STAT3) pathway. xref In addition, LMP1 upregulated c-myc via IL-6 induction followed by Jak3/STAT3 activation xref and it also upregulated PD-L1 via the STAT3, activator protein (AP)-1, and nuclear factor (NF)-kappa B pathways. xref Therefore, we infer that LMP1 may upregulate CD47 expression via the c-myc/IL-6/STAT3 pathway."

"MYC was found to bind directly to the promoters of the CD47 and PD-L1 genes."