A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

BRAF binds KSR1 and RAF1. 7 / 7
| 7
sparser
"KSR-1 and BRAF or CRAF interaction is enhanced by pharmacological RAF inhibition, regulating drug-induced RAF dimer formation ( xref – xref )."
sparser
"Using co-IP, we tested the interactions between the N-terminal regulatory regions (NTRs) of BRAF, CRAF, and KSR1."
sparser
"Using yeast two-hybrid (Y2H) screening, we identified the F311S mutation in MEK1 that abrogated KSR1, BRAF and CRAF binding ( xref )."
sparser
"We took advantage of the fact that kinase-dead forms of BRAF, CRAF and KSR1 could function as trans-activators to functionally separate the RAF dimer into an “activator” component (dead) and a “receiver” component (live), as proposed for other dimeric kinases ( xref )."
sparser
"In addition, association of B-Raf and/or Raf-1 with the scaffold protein KSR1 also modulates activation of MEK [ xref – xref ]."
sparser
"To confirm that dimerization is required, dimerization-impairing forms of kinase-dead BRAF (R509H), CRAF (DDEE/R401H) and KSR1 (DDEE/R615H) ( xref ) were tested."
sparser
"These mutations also increased binding to endogenous KSR1, BRAF, and CRAF ( xref )."