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Ubiquitin activates ATXN3. 9 / 11
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"Todi et al. [94] identified Lys-117 as the primary site of ubiquitination in wild-type and pathogenic ataxin-3 and showed that ubiquitin-dependent activation of ataxin-3 at Lys-117 is important for re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23684638
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"Further studies indicate that ubiquitin-dependent activation of ataxin-3 at Lys-117 is important for its ability to reduce high molecular weight ubiquitinated species in cells."
20943656
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"To exclude the possibility that conjugated ubiquitin (Ub) may interact with Atx3 and cause coaggregation of the PQE protein with Atx3 [55], we applied a mutant of Htt -N90 (3KR, three Lys residues replaced by Arg) for the experiment as described previously [51]."
37171184
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"Todi et al. [94] identified Lys-117 as the primary site of ubiquitination in wild-type and pathogenic ataxin-3 and showed that ubiquitin-dependent activation of ataxin-3 at Lys-117 is important for re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23684638
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"For SCA 3, it is known that both normal and polyQ expanded ataxin-3 localize to mitochondria [XREF_BIBR] and that degradation of polyQ expanded ataxin-3 via the UPS is promoted by an ubiquitin ligase in the outer mitochondrial membrane called MITOL [XREF_BIBR]."
25309920
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"Further studies indicate that ubiquitin dependent activation of ataxin-3 at Lys 117 is important for its ability to reduce high molecular weight ubiquitinated species in cells."
20943656
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"Cytoplasmic Ubiquitin Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone."
26808260
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"AT3 is composed of a structured globular N-terminal domain, the Josephin domain (JD), which displays ubiquitin hydrolase activity, followed by a disordered C-terminal tail containing two ubiquitin interacting motifs (UIMs) and the polyQ stretch of variable length, whose expansion beyond a certain threshold triggers SCA3 [XREF_BIBR, XREF_BIBR]."
26052945
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"The pattern of ubiquitin linkages on both forms of ataxin-3 are also reportedly similar, suggesting that toxicity and aggregation of polyQ-expanded ataxin-3 is unlikely to be caused by differences in ubiquitin linkage types [77]."
38497605