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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP26 binds PRC1. 2 / 6

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"Taken together, these results suggest that USP26 physically binds to components of the PRC1 complex, including RING1A, CBX4, and CBX6, and the interaction between USP26 and CBX4 or CBX6 is independent of the presence of RING1A."

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"To understand how Usp26 expression is regulated, we assessed the promoter-binding activity of Usp26 by PRC1 subunits using the ChIP–qPCR assay during RA-induced ESC differentiation, and observed that PRC1 components PCGF2 and Cbx7 occupation as well as H2A-ubi1 modifications decreased significantly in Usp26 promoter (Supplementary Fig. xref d), thus indicating that CBX7 containing PRC1 complex is a potential repressor of Usp26 ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...