IndraLab

Statements

USP11 binds SMAD7. 17 / 21
3 | 6 8
reach
"One, we hypothesized that USP11 binds and deubiquitylates SMAD7, thereby inhibiting the TGFbeta pathway."
22773947
sparser
"To confirm the specificity of the USP11–SMAD7 interaction, SMADs carrying an N-terminal FLAG tag were transiently transfected into HEK293 cells with or without the N-terminal HA-tagged USP11."
22773947
sparser
"USP11 but not USP15 binds specifically to SMAD7."
22773947
sparser
"USP11–SMAD7 interaction and potential complex formation raised two distinct possibilities for USP11 targets within the TGFβ pathway."
22773947
sparser
"One, we hypothesized that USP11 binds and deubiquitylates SMAD7, thereby inhibiting the TGFβ pathway."
22773947
sparser
"USP11 binds to Smad7, which then recruits USP11 to TGFβ receptor I where it interacts, deubiquitinates and stabilizes TGFβ receptor I to sustain Smad-mediated TGFβ signaling [ xref ]."
25606592
biogrid
No evidence text available
22773947
reach
"USP11 binds to Smad7, which then recruits USP11 to TGFbeta receptor I where it interacts, deubiquitinates and stabilizes TGFbeta receptor I to sustain Smad mediated TGFbeta signaling [XREF_BIBR]."
25606592
reach
"Conversely, a SMAD7 and USP11 complex would deubiquitylate the receptor, preventing its degradation and allow continued signalling (XREF_FIG)."
22773947
sparser
"TGFβ stimulation did not alter the SMAD7–USP11 interactions (see the electronic supplementary material, figure S1)."
22773947
reach
"We found that USP11 interacted more robustly with SMAD7 compared with any of the other SMAD proteins (XREF_FIG b)."
22773947
reach
"Size-exclusion chromatography also alluded to the possibility of potential complex formation between USP11 and SMAD7."
22773947
sparser
"In the case of USP11, SMAD7 does not appear to act exclusively as a scaffold for as SMAD7 does not appear to mediate the interaction between USP11 and TβRI, despite the fact that SMAD7 and USP11 being[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28923280
biogrid
No evidence text available
22773947
sparser
"This confirms our previous observation that USP11 interacts with SMAD7 [ xref ]."
24850914
reach
"We performed size-exclusion chromatography on HaCaT cell extracts in order to detect potential endogenous USP11 and SMAD7 complex formation."
22773947
biogrid
No evidence text available
24850914