IndraLab

Statements

CYLD inhibits TRAF6. 21 / 29
1 | 17 4
reach
"Thus, CYLD inhibits MyD88, RIP1 (receptor-interacting serine/threonine-protein kinase 1), TRAF2, TRAF6, TRAF7, and NEMO downstream to TLR signaling and regulates exaggerated inflammation which can lea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33075714
sparser
"TRAF6 are inhibited by A20, CYLD and OTUB2 that specially remove TRAF6 K63‐linked ubiquitination."
28744851
sparser
"Moreover, TRAF6 polyubiquitination and proinflammatory cytokine production were not suppressed in sNASP-deficient cells by CYLD overexpression, which led us to propose that CYLD cannot inactivate TRAF6 in the absence of sNASP."
40108019
reach
"Herein, our in vitro data demonstrated that CYLD expression negatively regulates TRAF6/sNASP axis-dependent proinflammatory cytokines."
40108019
reach
"In contrast, the loss of CYLD led to significant TRAF6 activation, and promoted TNF-α and IL-6 production."
40108019
reach
"Moreover, TRAF6 polyubiquitination and proinflammatory cytokine production were not suppressed in sNASP-deficient cells by CYLD overexpression, which led us to propose that CYLD cannot inactivate TRAF6 in the absence of sNASP."
40108019
sparser
"The ubiquitin-editing enzyme CYLD inhibits TRAF6 and -7 and TLR2 [ xref ]."
24009023
reach
"This group reported that depletion of SCF β-TrCP reduced osteoclast formation by stimulating accumulation of the deubiquitinase CYLD (and the subsequent deactivation of TRAF6)."
26706287
reach
"As shown in XREF_SUPPLEMENTARY, CYLD knockdown, using siCYLD, still enhanced TGF-beta-induced fibrotic response in TRAF6 depleted cells, thereby suggesting that CYLD inhibits Akt mediated fibrotic response at least in part by directly interacting with and deubiquitinating Akt."
22491319
reach
"The ubiquitin editing enzyme CYLD inhibits TRAF6 and -7 and TLR2 [XREF_BIBR]."
24009023
reach
"Thus, it is possible that CYLD functions in diverse pathways and loss of CYLD activity contributes to tumorigenesis via multiple mechanisms.Lys63-linked ubiquitin chains, synthesized in response to cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383
reach
"Further, the de-ubiquitinase CYLD has been shown to inactivate TRAF6 downstream of RANK in osteoclasts, as evidenced by removal of polyubiquitin chains, and the physiologic relevance of this mechanism is supported by the phenotype of CYLD deficient osteoclasts, which exhibit hyper-responsiveness to RANK."
26085208
sparser
"We further provide evidence to show that CYLD inhibits ubiquitinating TRAF-6 probably through directly interacting with sNASP."
40108019
reach
"CYLD was shown to inactivate TRAF2, TRAF6, and IKKγ by removing the K63-linked polyubiquitin chains ( Kovalenko et al., 2003 ), whereas A20 removes K63-linked polyubiquitin chains from TRAF2, TRAF6, a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17098202
reach
"In this study, we showed that cylindromatosis (CYLD) directly binds to the sNASP and prevents TRAF6 activation."
40108019
reach
"Similarly, de-ubiquitinating enzyme cylindromatosis (CYLD) inhibits NF-kappaB signaling via de-ubiquitination and inactivation of TNFR associated factor 2 (TRAF2) and TRAF6 [XREF_BIBR, XREF_BIBR]; de-ubiquitinating protease A20 inhibits NF-kappaB activation induced by Toll like receptor 4 (TLR4) via removing K63 linked polyubiquitin chains of TRAF6 [XREF_BIBR]."
27164085
reach
"Phosphorylation at S418 weakens the catalytic efficiency of CYLD, which impairs the degradation of its substrates TRAF2 and TRAF6 and, consequently, promotes NF-κB signalling."
37387450
reach
"CYLD inhibits NFκB-mediated activation by different TNF receptor family members due to deubiquitination and inactivation of TNFR-associated factor 2 (TRAF2) and TRAF6."
25444757
reach
"TRAF6 are inhibited by A20, CYLD and OTUB2 that specially remove TRAF6 K63‐linked ubiquitination."
28744851
reach
"As we described here for YOD1, CYLD is acting on TRAF6 and p62 complexes, but - in contrast to YOD1 - CYLD is not preventing the formation of TRAF6 and p62 aggregates, but is recruited to TRAF6 by p62."
28244869
reach
"CYLD inhibits the ubiquitination of TNFα receptor-associated factor (TRAF6), while TRAF6 conjugated to a Lys-63 (K63)-linked polyubiquitin chain is required for the activation of IKK and downstream signalling events [45–47]."
31182110