IndraLab

Statements

CYLD inhibits TRAF6. 12 / 19
1 | 1 8 2
reach
"As we described here for YOD1, CYLD is acting on TRAF6 and p62 complexes, but - in contrast to YOD1 - CYLD is not preventing the formation of TRAF6 and p62 aggregates, but is recruited to TRAF6 by p62."
28244869
reach
"Similarly, de-ubiquitinating enzyme cylindromatosis (CYLD) inhibits NF-kappaB signaling via de-ubiquitination and inactivation of TNFR associated factor 2 (TRAF2) and TRAF6 [XREF_BIBR, XREF_BIBR]; de-ubiquitinating protease A20 inhibits NF-kappaB activation induced by Toll like receptor 4 (TLR4) via removing K63 linked polyubiquitin chains of TRAF6 [XREF_BIBR]."
27164085
reach
"Thus, it is possible that CYLD functions in diverse pathways and loss of CYLD activity contributes to tumorigenesis via multiple mechanisms.Lys63-linked ubiquitin chains, synthesized in response to cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383
reach
"The ubiquitin editing enzyme CYLD inhibits TRAF6 and -7 and TLR2 [XREF_BIBR]."
24009023
reach
"As shown in XREF_SUPPLEMENTARY, CYLD knockdown, using siCYLD, still enhanced TGF-beta-induced fibrotic response in TRAF6 depleted cells, thereby suggesting that CYLD inhibits Akt mediated fibrotic response at least in part by directly interacting with and deubiquitinating Akt."
22491319
sparser
"The ubiquitin-editing enzyme CYLD inhibits TRAF6 and -7 and TLR2 [ xref ]."
24009023
reach
"CYLD inhibits the ubiquitination of TNFα receptor-associated factor (TRAF6), while TRAF6 conjugated to a Lys-63 (K63)-linked polyubiquitin chain is required for the activation of IKK and downstream signalling events [45–47]."
31182110
sparser
"TRAF6 are inhibited by A20, CYLD and OTUB2 that specially remove TRAF6 K63‐linked ubiquitination."
28744851
eidos
"TRAF6 are inhibited by A20 , CYLD and OTUB2 that specially remove TRAF6 K63-linked ubiquitination ."
28744851
signor
"The nf-kappab activation by cyld is mediated, at least in part, by the deubiquitination and inactivation of tnfr-associated factor 2 (traf2) and, to a lesser extent, traf6."
12917689
reach
"TRAF6 are inhibited by A20, CYLD and OTUB2 that specially remove TRAF6 K63‐linked ubiquitination."
28744851
reach
"Further, the de-ubiquitinase CYLD has been shown to inactivate TRAF6 downstream of RANK in osteoclasts, as evidenced by removal of polyubiquitin chains, and the physiologic relevance of this mechanism is supported by the phenotype of CYLD deficient osteoclasts, which exhibit hyper-responsiveness to RANK."
26085208