IndraLab

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MINDY3 activates CDKN1B. 3 / 3
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"In summary (XREF_FIG), we have shown that (a) CARP is downregulated in stomach cancer tissues; (b) CARP functioned as a tumor suppressor by inducing apoptosis, and inhibiting proliferation, migration and adhesion; (c) CARP might cause G1 arrest by promoting p27 and p21 nuclei location, and inhibits cyclin-E and CDK2 activities; (d) rs2297882 in the CARP Kozak sequence is associated with the downregulation of CARP expression and with the susceptibility to stomach cancer."
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"A similar tendency in the changes of these proteins expression levels were observed in A549 cells, suggesting that CARP-induced p27 activation was responsible for CARP-induced G1 arrest and blockage of the G1/S transition."
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"A similar tendency in the changes of these proteins expression levels were observed in A549 cells, suggesting that CARP induced p27 activation was responsible for CARP induced G1 arrest and blockage of the G1/S transition."
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