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BDNF bound to NTRK2 activates ERK. 24 / 24
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"The binding of BDNF to TrkB receptors and/or modulation of NMDA receptors activates AKT, ERK1/2 or PKC; the main activators of the mTOR signaling (Hoeffer and Klann, 2010; Numakawa et al., 2014; Chang[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The binding of BDNF to TrkB triggers the dimerization of the receptor via conformational changes and the autophosphorylation of tyrosine residues in the intracellular domain of the receptor, leading t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_BIBR BDNF bound TrkB receptors to trigger PI3K and Akt and mitogen activated protein kinase and extracellular signal regulated kinase pathways."
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"BDNF binds to receptor TrkB and activates the phospholipase C (PLC), PI3K, and MAPK/ERK pathways (Minichiello et al., 2002; Yoshii and Constantine-Paton, 2007)."
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"These findings suggest that the signal cascade reaction triggered by BDNF binding to TrkB, through ERK signal transduction and activation of AKT/mTOR signal pathway, may be the key molecular mechanism[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Concurrently, the BDNF-TrkB complex also modulates the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, which is instrumental in restoring impaired neural net[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Meanwhile, the BDNF receptor TrkB is predominantly expressed in oocytes within the ovary [24], and the interaction between BDNF and TrkB triggers the activation of the ERK1/2 pathway [25]."
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"It is hypothesized that BDNF binds to tropomyosin related kinase B (TrkB), activates downstream ERK and AKT-mTOR signaling, and ultimately regulates synaptic protein synthesis, thereby affecting synap[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"BDNF can bind to TrkB, its receptor in the neurons, and activate the signaling pathways of Akt and ERK (Leal et al., 2014)."
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"Moreover, the binding of BDNF to the TrkB receptor is known to promote key downstream signaling pathways, mainly those leading to phosphorylation and activation of ERK and CREB [44,45]."
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"Binding of BDNF to postsynaptic TrkB induces increases in C-fiber activity and activation of PKC- and ERK- mediated signaling cascades (Kerr et al., 1999; Pezet et al., 2002; Yajima et al., 2005)."
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"Its receptor TrkB is mainly expressed on oocytes within the ovary [24], and the binding of BDNF to TrkB can activate the ERK1/2 pathway [25]."
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"Tyrosine kinase receptor B (TrkB) is an endogenous receptor for BDNF, and the BDNF/TrkB complex can activate the mitogen-activated protein kinase/extracellular signal-regulated kinase, phospholipase Cγ and phosphatidylinositol 3-kinase pathways to promote neuronal survival after OGD/R (Liu et al., 2017; Tejeda and Díaz-Guerra, 2017; Kowiański et al., 2018)."
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"BDNF binds to its receptor TrkB and activates ERK1/2 and CREB."
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"BDNF binds to its signaling receptor TrkB, which is abundantly expressed by adult RGCs, and activates the pro survival ERK1/2 and Akt pathways."
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"In this context, the interaction between BDNF and TrkB elicits the activation of the PI3K/AKT and ERK pathways, culminating in CREB phosphorylation and consequently enhancing retinal resilience (75,82)."
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"By binding to its cognate receptor TrkB, BDNF triggers TrkB autophosphorylation, which activates several signaling pathways including phosphoinositide 3 kinase (PI3K)/Akt, Ras and extracellular signal regulated kinase (ERK), and phospholipase Cgamma (PLCgamma)/cAMP responsive element binding protein (CREB) pathways."
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"BDNF binds to TrkB triggering the activation of one or more of three major signaling pathways involving phosphatidylinositol 3-kinase (PI3K), phospholipase C gamma (PLC-gamma) and extracellular signal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In primary cerebellar granule neurons, BDNF binding to TrkB receptor triggers its movement into lipid rafts and activates ERK signaling on the pre-synaptic side, which is required for neurotransmitter release and synaptic plasticity."
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"In our study, western blot analysis suggested that the BDNF synthesized and secreted by N-Fbs is likely to be the mature BDNF (approximately 14 kDa), which binds to the TrkB receptor with high affinity and activates the Ras/ERK, PI3-K/AKT, and phospholipase C-γ pathways."
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"Our results suggested that BDNF bound its specific receptor TrkB to activate the downstream molecule ERK, and the BDNF/TrkB/ERK pathway participated in the molecular regulation of auditory development by Loxhd1b."
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"BDNF binds to its high-affinity receptor TrkB, triggering the activation of one or more of three major signalling pathways, such as CaMKIIα, phosphatidylinositol 3-kinase (PI3K), phospholipase C gamma (PLC-γ), and extracellular signal-regulated kinase 1/2 (ERK1/2), regulating certain forms of synaptic plasticity, including long-term potentiation and affecting synaptic transmission (Koike et al. 2013; Adachi et al. 2017; Xenos et al. 2018)."
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"They demonstrated that the BDNF mimetic LM22A-4, which has a structure similar to the loop2 domain of BDNF (binding domain for TrkB), could bind to TrkB to stimulate both ERK and Akt signaling pathway[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this context, the released BDNF binds to TrkB and activates Ras/ERK, phosphatidylinositol3-kinase/Akt and phospholipase C-g(PLC-g) signaling cascades, which in turn stimulate glutamate and GABA release as neurotransmitters (24, 25, 80)."
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