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BDNF bound to NTRK2 activates ERK. 9 / 9
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"BDNF binds to receptor TrkB and activates the phospholipase C (PLC), PI3K, and MAPK/ERK pathways (Minichiello et al., 2002; Yoshii and Constantine-Paton, 2007)."
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"BDNF binds to its signaling receptor TrkB, which is abundantly expressed by adult RGCs, and activates the pro survival ERK1/2 and Akt pathways."
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"XREF_BIBR BDNF bound TrkB receptors to trigger PI3K and Akt and mitogen activated protein kinase and extracellular signal regulated kinase pathways."
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"The binding of BDNF to TrkB receptors and/or modulation of NMDA receptors activates AKT, ERK1/2 or PKC; the main activators of the mTOR signaling (Hoeffer and Klann, 2010; Numakawa et al., 2014; Chang[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"BDNF can bind to TrkB, its receptor in the neurons, and activate the signaling pathways of Akt and ERK (Leal et al., 2014)."
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"BDNF binds to its receptor TrkB and activates ERK1/2 and CREB."
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"Binding of BDNF to postsynaptic TrkB induces increases in C-fiber activity and activation of PKC- and ERK- mediated signaling cascades (Kerr et al., 1999; Pezet et al., 2002; Yajima et al., 2005)."
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"By binding to its cognate receptor TrkB, BDNF triggers TrkB autophosphorylation, which activates several signaling pathways including phosphoinositide 3 kinase (PI3K)/Akt, Ras and extracellular signal regulated kinase (ERK), and phospholipase Cgamma (PLCgamma)/cAMP responsive element binding protein (CREB) pathways."
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"In primary cerebellar granule neurons, BDNF binding to TrkB receptor triggers its movement into lipid rafts and activates ERK signaling on the pre-synaptic side, which is required for neurotransmitter release and synaptic plasticity."
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