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SRC phosphorylates AKT. 138 / 162
1 | 112 25 22 1
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"In conclusion, E 2 treatment promoted a SRC mediated nucleus-plasma membrane shuttle of ESR1, and increased AKT phosphorylation, Slc2a4 / GLUT4 expression and plasma membrane GLUT4 translocation; consequently, improving insulin stimulated glucose uptake."
28729437
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"Moreover, this FAK/Src signaling led to Akt phosphorylation and eventual β-catenin signaling [78]."
| PMC
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"The starting point is the G i/o -protein dependent PI3K activation that leads to the membrane recruitment of Akt, which becomes tyrosine phosphorylated by c-Src with the subsequent phosphorylation in both the activation loop within the kinase domain [A-loop (T308)] and the hydrophobic motif in the C-terminal region [HM (S473)] by PDK1 and mTORC2, respectively."
26935831
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"We found that the levels of phosphorylated (p-) AKT, mTOR, Bad, Src, FAK, and paxillin were higher in the stable CHIP knockdown Panc-1 and BxPC-3 cells, and the levels of p-AKT, p-mTOR, p-Bad, p-Src, p-FAK, and p-paxillin significantly decreased in CHIP OE cells, while the total protein did not change in the CHIP knockdown and CHIP OE cells."
24722501
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"CA-Src transfection resulted in a robust increase in phosphorylation of Src, Akt and Beclin1, which was significantly blocked by the inhibition of Src kinase with Src inhibitor, PP2 (XREF_FIG)."
26960433
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"PDK 1 and 2 and Src then phosphorylate the Akt (serine/threonine protein kinase), promoting proliferation [59,60,61]."
32545311
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"The Src kinase then induces AKT phosphorylation and the activated AKT in turn phosphorylated GSK-3β."
30619732
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"To explore the pathway by which rGal3C affects HepG2 cells, alteration of phosphorylation of Erk1/2, Akt and FAK and SRC were detected by western blotting."
28701735
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"In human tracheal smooth muscle cells, TNF-alpha induced MMP-9 expression and Akt phosphorylation in a time dependent manner, which was attenuated by the inhibitors of Src (PP1), epidermal growth factor receptor (AG1478), PDGFR (AG1296), and PI3K (LY294002), respectively, revealed by reporter gene assay, RT-PCR, zymographic, and Western blot analyses."
17158602
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"Thus, GDF-15 via c-src phosphorylation of EGFR, ErbB2, and ErbB3 as well as Akt and p38, Erk1/2, and JNK mitogen activated protein kinases (MAPKs), significantly induces MMP-9 expression and leads to the invasiveness of BC cells (Park et al. 2010)."
31693861
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"76 In contrast, G protein mediated Akt activation by ghrelin involves Gbetagamma triggered-PI3K activation, Akt phosphorylation by c-Src and subsequently by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and mammalian rapamycin and insensitive complex 2 (mTORC2)."
28328745
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"CML-derived exosomes transfer miR-92a and activate SRC signaling, which induces phosphorylation of AKT and ERK1/2 and oncogenic signaling by BCR-ABL."
34922630
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"Moreover, blockade of Src activity by PP2 prevented δ-opioid -induced phosphorylations of PDGFRβ, Akt and GSK-3β."
21276805
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"Therefore, the role of p300 in mediating LPS induced VCAM-1 expression also needs to be investigated in HTSMCs.In the present study, we investigated that Akt was phosphorylated by Src and EGFR transac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18182168
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"SRC can phosphorylate STAT3, AKT and EGFR to regulate various biological activities [ xref , xref , xref ]."
39459003
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"Inhibition of Src or DT-13 in HUVECs reduced the phosphorylations of Src, PI3K, and Akt."
28855900
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"Dual targeting of Src and SHP-2 induces an additive or supra-additive loss of phosphorylation of Akt and ERK-1/2 and corresponding increases in expression of apoptotic markers, relative to targeting either protein individually."
23271399
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"Inhibition of Src family kinases (SFKs) with PP1 blocked EGFR, AKT and ERK1/2 phosphorylation, as well as RPTC dedifferentiation."
21780115
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"However, inhibition of SRC did not decrease AKT phosphorylation."
27803182
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"Additionally, interstitial fluid flow has been reported to sense mechanical signals via the integrin/Src pathway, which leads to the phosphorylation of FAK and Akt, promoting macrophage polarization toward the M2 phenotype, as evidenced by increased expression of M2 macrophage markers such as ArgI, CD206, and TGFβ [209]."
40075523
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"Apelin also promoted the phosphorylation of PI3K and Akt, while the c-Src and PI3K inhibitors diminished apelin-induced promotion of PI3K and Akt phosphorylation (Figure 6I–K)."
36291151
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"Blockade of Src, but not the EGF receptor, inhibited Akt and ERK1/2 phosphorylation."
15833899
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"In contrast, the combination of dasatinib with afatinib abrogated c-Src phosphorylation and downstream phosphorylation of AKT and ERK."
32517369
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"Furthermore, knockdown of CIgG upregulated PTP-BAS mRNA and protein expression, whereas cisplatin downregulated PTP-BAS protein, but not mRNA expression; knockdown of PTP-BAS upregulated phosphorylation of Src, PDK1, AKT, and blocked CIgG knockdown-mediated enhancement of cisplatin-induced inhibition of cell proliferation."
32730654
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"We observed that TNF-alpha-stimulated Akt phosphorylation was reduced by the inhibition of c-Src or PDGFR."
24361597
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"The complex allows c-Src to phosphorylate Tyr315 and 326 residues of Akt, which are necessary for subsequent phosphorylation of Akt on thr308 and ser473 by PDK1 and PDK2, separately ( xref )."
35096302
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"Therefore, this is the first study to establish a requirement for Src-dependent Akt phosphorylation in promoting, GABA B R-induced chemotaxis."
25725285
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"Furthermore, a Src kinase specific inhibitor blocked the increase in phosphorylations of c-Src, Akt and eNOS."
22771325
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"In addition, APPL1 significantly decreases the tyrosine phosphorylation of Akt by the nonreceptor tyrosine kinase Src, which is critical for Akt-mediated cell migration."
22379109
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"Stimulation of the Src/FAK/p130Cas/BCAR1 adhesion signalling pathway in tamoxifen treated MCF-7 cells does not cause increased migration; however, there is Src dependent phosphorylation of the cell survival molecule Akt."
16799644
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"The extract of R. acetosa showed inhibition of the collagen-induced platelet aggregation by modulating the phosphorylation of MAPK, PI3K/Akt, and Src family kinases and inhibited the ATP release in a dose dependent manner (25—200 μg/mL) [176]."
35710954
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"In primary murine aortic smooth muscle cells, mDia1 is required for RAGE ligand induced membrane translocation of c-Src, which leads to Rac1 activation, redox phosphorylation of AKT and GSK3beta and consequent smooth muscle cell migration."
22511750
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"Down-regulation of endogenous XB130 with siRNA reduced c-Src activity, IL-8 production, EGF induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells."
17412687
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"APPL1 regulates the tyrosine phosphorylation of Akt by Src."
22379109
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"Because tyrosine phosphorylation of Akt by Src was recently shown to be important in both the activation of Akt and its biological function ( xref ; xref ; xref ), we hypothesized that Src-mediated tyrosine phosphorylation of Akt was critical for its effects on migration."
22379109
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"Additionally, following insulin stimulation, Src binds to and phosphorylates Akt contributing to its full activation [20,21]."
24582588
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"We began to test this hypothesis by assessing tyrosine phosphorylation of Akt by Src in HT1080 cells."
22379109
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"Targeting Src activity by Nintedanib abolished Noggin effect on Akt and ERK1/2 phosphorylation (Fig.  xref c), which strongly suggests that Noggin-activated Src kinase may directly phosphorylate Akt and ERK1/2 kinases xref – xref ."
38509118
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"In addition, the hyperproliferation and enhanced phosphorylation of ERK1/2 and Akt in VSMC from SHR were attenuated towards WKY levels by the inhibitors of MAPK, PI3K, c-Src, and antioxidants, whereas PT was unable to attenuate the enhanced phosphorylation of ERK1/2 and Akt."
26524499
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"Furthermore, Src silencing inhibited Akt phosphorylation and cell growth, with this inhibitory effect further augmented by erlotinib treatment."
23872583
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"We recently found that either inhibition of Src kinase with PP2 or inhibition of the EGFR with AG1478 blocked ACh-induced Akt phosphorylation in the isolated rabbit heart [10] ."
15010282
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"Thus, acetylcholine increased c-Src Y416 phosphorylation and CD133 Y828 phosphorylation.CD133 interacts with p85 depending on its Y828 phosphorylation, consequently increasing PI3K activity and activa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31830559
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"Thus, these results suggest APPL1 reduces the amount of active Akt in cells by inhibiting tyrosine phosphorylation of Akt by Src."
22379109
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"We found that ErbB inhibition by either gefitinib or CI-1033 induced c-Src activation, which in turn mediated ErbB3 re-phosphorylation and Akt re-activation."
18769157
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"These results suggest that GRP induces c-Src dependent Akt phosphorylation but EGF stimulates Akt phosphorylation directly, without involvement of c-Src."
17349623
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"Because of the importance of receptor and nonreceptor tyrosine kinases in G protein coupled receptor signaling, we studied the role of epidermal growth factor receptor (EGFR), c-Src, and phosphoinositide 3-kinase (PI3K) on OT induced PGF (2 alpha) production in association with cyclooxygenase 2 (COX2) expression and ERK1/2 and Akt phosphorylation."
20080869
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"Thus, APPL1 can inhibit Akt function by reducing the tyrosine phosphorylation of Akt by Src, which hinders cell migration."
22379109
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"The pharmacological inhibition of Src family kinases reduced the PDGF-induced phosphorylation of Akt and ERK and proliferation (Figs."
15115658
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"Tyrosine phosphorylation of Akt by Src enhances the activity of Akt."
22379109
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"The results are shown in Figure 5A,D. Knockdown of c-Src expression reduced phosphorylation of PI3K and downstream AKT protein, compared with the NC group."
36614217
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"Since PDGFR associates with the first PDZ domain of NHERF1 and NHERF2, we suggest that these PDZ domain proteins may link PDGFR to YAP65, and thus may be involved in the NHERF2-dependent increase of P[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15115658
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"The dramatic phosphorylation of Akt and to a lesser extent MAPK and Src, in response to SDF-1alpha in duct cells of the IFNgammaNOD transgenic mice, indicate a potential involvement of these signaling proteins in the regulation of migration, proliferation, and survival of the pancreatic progenitor population."
14638861
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"Inhibition of Src kinase decreased eNOS and Akt phosphorylation in response to DPP4-inhibition NO XREF_BIBR, XREF_BIBR."
25858071
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"Inhibition of c-Src attenuated Rac1 and p38 MAPK activations and Ser (473) phosphorylation of Akt."
19074832
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"Further, FAK and CDCP1 tyrosine phosphorylation were recently shown to be reciprocally related, xref , xref and CDCP1 cleavage-dependent increases in CDCP1 tyrosine phosphorylation protect cells from anoikis through mechanisms involving enhanced Src and PKCδ tyrosine phosphorylation and activation of the pro-survival kinase Akt. xref This latter study demonstrated that plasmin is an important regulator of CDCP1 cleavage in vivo ."
22543582
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"Interestingly, Src inhibition also blocked Akt phosphorylation in response to 3h HRG exposure (XREF_FIG), suggesting that Src is upstream of PI 3-kinase/Akt in ErbB4 induced signaling."
20585313
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"LPS signaling via TLR4 induces Src family kinase mediated phosphorylation of Pyk2 and paxillin XREF_BIBR, XREF_BIBR, XREF_BIBR as well as phosphorylation of the PI3K and AKT pathway XREF_BIBR."
24824795
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"Inhibition of Src abrogates the stimulation of IGF-IR, Akt and Erk1/2 phosphorylation."
25226534
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"Furthermore, Src antagonist PP2 caused a significant decrease in the phosphorylation of FAK, p130 (Cas), paxillin, and PI3K and Akt."
24162594
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"Some of them, like Akt phosphorylation by Src, are probably not involved in the PrP phenotype, as implied by Bremer and colleagues."
25364767
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"Together, these data indicate that CDCP1 mediated survival signaling in vivo involves Src dependent phosphorylation of 70 kDa CDCP1, Akt activation, and suppression of PARP1 cleavage, all of which are linked directly to the proteolysis induced cleavage of CDCP1 expressed on the surface of bona fide carcinoma cells or transformed cells."
22179830
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"We thus took advantage of specific Src kinase activity inhibitor PP1 and SU6656 to investigate the effects of Src kinase on EGFR transactivation and subsequent Akt activation, and found that Src kinase inhibition blocked PTHrP (1–34)-induced EGFR and Akt phosphorylation (Figure 2D)."
30926678
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"Inhibition of Src by Src inhibitors attenuated PDGF-A-stimulated phosphorylation of Akt and Dyn2 and glioma cell migration."
21996738
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"The Src kinase inhibitor markedly inhibits dsRNA elicited phosphorylation of Akt, a downstream target of PI3-K."
18262679
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"Src inhibition leads to suppressed AKT phosphorylation in MCF7:5C cells (50)."
30655322
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"SRC inhibition completely blocked phosphorylation of AKT and CBL and increased p38 and HSP27 phosphorylation to effectively transduce TRAIL induced signals [XREF_BIBR, XREF_BIBR]."
28503088
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"Therefore, EPLIN may stabilize focal adhesions, presumably by interaction with their component paxillin.To date, several paxillin binding proteins have been reported to regulate focal adhesion turnove[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24694988
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"Regulation of Akt phosphorylation by Src and β-arrestins in 3T3-L1 preadipocyte cells."
19262695
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"In addition, as shown in Fig. 3 B , Src inhibition completely prevented the phosphorylation of c-Cbl and Akt and increased p38/HSP27 phosphorylation as well as cellular apoptosis."
23085457
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"One possibility is that Src may regulate this pathway through activation of AKT since Src can directly induce AKT phosphorylation and AKT can induce phosphorylation of ubiquitin specific protease 4 (USP4), a deubiquitinating enzyme that prevents TGF-beta receptor I degradation [XREF_BIBR]."
29137389
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"In this complex, Src promoted the activation of Her2 while maintaining its own phosphorylation, and the phosphorylated Her2 driven activation of the PI3K/AKT and MAPK/ERK pathways, thereby leading to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35504333
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"At the same time, we excluded the possibility that the FAK and Src complex mediated survival, since inhibition of Src did not induce cell detachment and dephosphorylation of AKT even if its target FAKY861 was decreased (XREF_SUPPLEMENTARY A and S2B)."
27509133
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"Once assembled, such a complex leads to phosphorylation of FAK, Akt and paxillin The S1 peptide that displaces the upstream AR, Src, PI3-K, and FAK complex also inhibits phosphorylation of FAK, Akt and paxillin."
30872694
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"IGF-IR expression is diminished when PTEN is expressed, indicating that Src transformation leads to an increase in PI3K activation, phosphorylation of Akt, and upregulation of IGF-IR."
12793901
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"Src-induced phosphorylation of Akt at Tyr315/Tyr326 is required to precondition Akt for membrane binding ( xref )."
25808491
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"Along with TNF-alpha and Fas, the Src homology domain 2 (SH2) containing tyrosine phosphatase-1 (SHP-1) plays an important role in apoptosis and a negative regulatory role in the phosphorylation of Akt [XREF_BIBR - XREF_BIBR]."
21501867
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"Cyclosporine H inhibited fMLP (0.1 μM)-induced ERK, AKT Src phosphorylation ( Fig. 3 A, C, E)."
34144024
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"AS c-Src ODN inhibited Akt phosphorylation, confirming Src is upstream of PI3-kinase in IL-18-induced RA synovial fibroblast signaling."
12105209
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"Cc-ME dramatically suppressed the phosphorylation of Src and AKT induced by Src transfection in HEK293 cells in a dose dependent manner (XREF_FIG)."
29725354
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"Akt phosphorylation induced by either stimulus was completely inhibited by the Src family tyrosine kinase inhibitor PP2 (10 muM)."
12782324
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"Stimulation of the Src/FAK/p130Cas/BCAR1 adhesion signalling pathway in tamoxifen-treated MCF-7 cells does not cause increased migration; however, there is Src-dependent phosphorylation of the cell survival molecule Akt."
16799644
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"It also promotes angiogenesis by affecting the expression of pro-angiogenic genes by interacting with the extracellular matrix and activating c-Src and FAK, which allows the phosphorylation of Akt to produce HIF1-α [69,81,82,83,84,85]."
37189651
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"As shown in Fig. 7 C, RNAi mediated knockdown of SRC moderately prevent both AKT and ERK1/2 phosphorylation and induces PARP cleavage, indicative of apoptosis activation in cells treated with SHIP2 in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33181128
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"However, SRC depletion induces only moderate decrease in ERK1/2 and AKT phosphorylation in cells treated with SHIP2 inhibitor and H2O2 ( Fig. 7 C)."
33181128
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"Inhibition of Src kinase decreased eNOS and Akt phosphorylation, in contrast to a lack of any effect on insulin mediated activation of the eNOS-Akt, suggesting that alogliptin mediates vasodilation through Src kinase mediated effects on eNOS-Akt."
21397040
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"Western blotting indicated kaempferol may reduce AKT and GSK3β phosphorylation, leading to lower expression of invasion-related genes SRC, MMP9, CXCR4, KDR, and MMP2."
39132822
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"Similarly, Chandra and colleagues reported that the inhibition of Src tyrosine kinase in THP-1 cells reduced Akt phosphorylation and increased M. tb."
31130711
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"The starting point is the G i/o -protein dependent PI3K activation that leads to the membrane recruitment of Akt, which is phosphorylated at Y by c-Src with the subsequent phosphorylation at A-loop (T308) and HM (S473) by PDK1 and mTORC2, respectively."
19262695
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"This could be due to the inhibitory action of RIR-2 on fMLP induced Src phosphorylation, leading to a reduction in PI3K activity which subsequently decreases AKT phosphorylation."
29601810
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"Caveolar Src-phosphorylation at the α1-Na/K-ATPase regulated Survivin/SMAC expressions, leading to cellular "switch" from apoptosis to cell division via the activation of the PI3K/Akt pro-survival pathway with concomitant inhibition of the FoxO cascade."
35553748
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"This suggests polarized CD133 and integrin evoked Src activation (in cells cultured on collagen- or laminin coated dishes) enhanced phosphorylation of GSK3beta and its potential upstream regulator Akt as well as the subsequent increase and nuclear translocation of beta-catenin."
26515729
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"Similarly, Src kinase inhibitors, which decrease Akt phosphorylation, also counteracted the protection of mitochondrial membrane potential supporting the pivotal role of Akt in cytoprotection."
16115861
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"In the present study, bortezomib induced phosphorylation of EGFR, Src and Akt in hepatoma cells and inhibition of Src reduced bortezomib induced EGFR and Akt phosphorylation."
25338626
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"Also, Src activation could subsequently lead to MAPK, PKC, and PKB phosphorylation."
29587860
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"Inhibition of p38, Src, and EGFR kinases with pharmacological inhibitors markedly reduces Akt phosphorylation induced by Zn2+."
15980035
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"The activation of the Src kinase can promote phosphorylation of Cav-1, Akt and eNOS, resulting in eNOS dissociation from Cav-1."
27011179
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"In addition, Src specific inhibitor PP2 caused a significant decrease in the phosphorylation of FAK, p130 (Cas), paxillin, PI3K and Akt, and ERK1/2."
23933586
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"Some of them, like Akt phosphorylation by Src (Chen et al., xref ; Jiang and Qiu, xref ), are probably not involved in the PrP phenotype, as implied by Bremer and colleagues."
25364767
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"The phosphorylation of the EGFR and Akt could be significantly enhanced by G1 (p <; 0.05) and inhibited by a Src family kinase inhibitor."
23163984
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"Moreover, APPL1 inhibits the ability of Akt to promote migration by impairing Src mediated tyrosine phosphorylation of Akt."
22379109
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"The results are shown in xref A,D. Knockdown of c-Src expression reduced phosphorylation of PI3K and downstream AKT protein, compared with the NC group."
36614217
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"The recruitment of β-arrestin to the AT1R possibly engages a pathway where Src phosphorylates and activates Akt, which in turn phosphorylates endothelial nitric oxide synthase (eNOS) ( xref ; xref ), which could further provide a connection between AT1R-arrestin function and cardiovascular tone via nitric oxide regulation ( xref )."
30546309
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"Because previous work showed that the major Src phosphorylation sites in Akt, which are important in regulating its activity and function, are tyrosines 315 and 326, we mutated these tyrosine residues to phenylalanines."
22379109
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"Targeting Src activity by Nintedanib abolished Noggin effect on Akt and ERK1/2 phosphorylation (Fig. 4c), which strongly suggests that Noggin-activated Src kinase may directly phosphorylate Akt and ERK1/2 kinases ."
38509118
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"The cetuximab mediated phosphorylation of IGF-1R, VEGFR-2 and Akt was inhibited by the EGFR kinase inhibitor, AG1478, and the Src kinase inhibitor, PP2."
30720056
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"Overall, we revealed that Noggin may activate FGFR2 followed by Src kinase activation that consequently leads to downstream Akt and ERK1/2 kinases phosphorylation."
38509118
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"Pretreatment with AG1478 (AG, 30 μM) significantly inhibited IL-1β-stimulated phosphorylation of ERGF and Akt, but not c-Src."
35740292
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"Although Src inhibition suppressed the phosphorylation of AKT, c-JUN, and p38, none of inhibitors targeting these kinases reversed the dual-drug resistance in model cells."
| PMC
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"Although we cannot exclude the possibility that eHsp90 influences LRP1 endocytic function, our data support a model whereby eHsp90-LRP1 functions as a signal transduction complex to regulate src dependent AKT phosphorylation, resulting in P-EphA2 S897 directed cell motility and invasion."
21408136
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"Then Src phosphorylates Akt at Y residue (s), which triggers Akt A-loop (T308) and HM (S473) phosphorylation by PDK1 and mTORC2 XREF_BIBR."
19262695
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"In addition, knockdown of c-Src by siRNAs reduced cell proliferation and phosphorylation of ERK1/2, AKT, and GSK3beta."
23615537
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"Inhibition of c-Src in MCF-7 cells significantly reduces cell proliferation, migration, attachment, spreading, and Akt phosphorylation [35]."
29079189
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"Src activation induced the phosphorylation of caveolin-1, Akt and eNOS, and promoted dissociation of eNOS from caveolin-1."
16973909
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"Moreover, transfection of kinase-dead c-Src inhibited 17beta-estradiol-induced Akt phosphorylation, whereas constitutively active c-Src increased basal Akt phosphorylation."
12431978
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"Thus, activation of PI3K and Src family kinases apparently converges to induce phosphorylation of Akt."
11438205
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"ANG II induced phosphorylation of Akt and p70S6K and EGFR, which was abrogated by knockdown of c-Src by small interference RNA."
17493931
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"The G i/o -protein dependent PI3K activation leads to the membrane recruitment of Akt, which is phosphorylated at tyrosine (Y) by cSrc with the subsequent phosphorylation by PDK1 and mTORC2."
23557604
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"Mechanistically, SRC inhibition blocked AKT phosphorylation and blunted MEKi driven AKT feedback activation, but only in double mutant cells (XREF_FIG, XREF_SUPPLEMENTARY)."
28746882
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"The Src kinase inhibitor AZD0530 (Saracatinib), which inhibits the phosphorylation of paxillin and Akt, was used to confirm that the observed effects on cell adhesion were actually mediated by molecules of the integrin signaling pathway."
21747918
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"It was shown that an inhibitor of Src tyrosine kinase also reduced Akt phosphorylation."
19712465
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"In contrast, an inhibitor of the Src family tyrosine kinase prevented the nicotine induced Akt phosphorylation but not ERK phosphorylation."
12472891
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"C-Src may activate the PI3K pathway by 3 distinct mechanisms : direct interaction and phosphorylation of AKT; interaction and activation of PI3K; and reversal of PTEN activity."
21106725
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"Src Enhances Akt Phosphorylation and Its Localization to Podosomes."
25575302
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"Akt is phosphorylated at Y by the membrane bound Src via the interaction between its C-terminal proline rich motif and the SH3 domain of Src."
19262695
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"At the molecular level, these direct-acting antivirals inhibit the phosphorylation of Akt and the ephrin type A receptor 2 (EPHA2) by destabilizing a Src-EPHA2 complex, although they do not affect the general kinase activity of Src."
39226729
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"Stimulation of M3R by carbachol leads to the activation of EGFR mediated by Src, subsequently phosphorylating ERK and Akt pathways and suppressing apoptosis mediated by caspase 3/7 [124]."
39014509
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"al. [XREF_BIBR] reported that the Src family kinase specific inhibitor, PP2, suppressed 17beta-estradiol-induced PI3-K activation and also decreased 17beta-estradiol-induced AKT phosphorylation."
25328014
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"AGEs activate both NAD (P) H oxidase and Src, which ultimately leads to the phosphorylation and activation of both IGF-1 receptor and Akt downstream in 3T3-L1 preadipocyte cells [XREF_BIBR]."
24416618
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"As shown in Figure 2B‐E, individual treatments of erlotinib, AG490, LY294002 and PD98059 all led to a substantial decrease in YD‐38 cell survival.3.3 Knockdown of Src causes a strong inhibition of the phosphorylation of EGFR, STAT-5, PKB and ERK-1/2 in YD-38 human oral cancer cells."
34318593
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"Either silencing of SRC or dasatinib, a SRC family kinase (SFK) inhibitor, suppressed AKT phosphorylation and cell growth."
35643725
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"In the present study, we investigated that Akt was phosphorylated by Src and PDGFR transactivation stimulated by IL-1b."
17299794
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"FOXO1 is inhibited by SRC-induced AKT phosphorylation, which activates pAKT and inhibits FOXO1."
39488683
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"Through its interaction with Vascular Endothelial Cadherin (VE-cadherin), phosphorylated PECAM-1 initiates Src-dependent phosphorylation of VEGFR2 and -3 and subsequent Akt activation (Tzima et al., 2005; Coon et al., 2015)."
39161593
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"In addition, recent studies have shown that Src kinase, another upstream protein kinase in the HGF/c-Met signaling to eNOS ( Maejima et al., 2003 ), also acts upstream to geldanamycin-induced Akt phos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18242595
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"The Src family kinase inhibitor, PP2, the PI3 kinase inhibitor, wortmannin, or the Syk kinase inhibitor, BAY 61-3606, abrogated phosphorylation of Akt and GSK3beta."
21059245
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"In purified mouse PGCs isolated 11.5-12.5 days post-coitum, KL stimulates the phosphorylation of Akt by either PI3K or Src kinases."
27234585
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"IL-1beta-stimulated c-Src, PDGFR, and Akt phosphorylation and proMMP-9 expression were attenuated by the inhibitors of c-Src (PP1), PDGFR (AG1296), and PI3K (LY294002), respectively, or transfection with dominant negative plasmid of c-Src or short hairpin RNAs of PDGFR and Akt."
18315570
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"Furthermore, pharmacological inhibition of Src by PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazole (3,4-d) pyrimidine) decreased PKB phosphorylation."
16998541