IndraLab

Statements

TNF activates SCN8A. 11 / 11
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reach
"TNF-alpha induces RGC hyperexcitability by selectively upregulating Nav1.6 currents."
34419081
reach
"In this study, we show that TNF-α enhanced RGC excitability by upregulating Nav1.6 channels through activating TNFR1, thus contributing to RGC apoptosis."
34419081
signor
"TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels."
26112872
reach
"Further analysis revealed that TNF-alpha selectively upregulated Nav1.6 subtype of Na + currents in RGCs."
34419081
reach
"One of the major findings in this study is that TNF-α induced RGC hyperexcitability was mediated by selectively upregulating Nav1.6 currents although RGCs express the other subtypes of Na channels, such as Nav1.1 and Nav1.2 [45–47]."
34419081
reach
"Considering the TNF-α-mediated regulation of the p-STAT3 activity, these studies suggested an enhanced interaction between p-STAT3 and p300, possibly mediated by TNF-α, in the Scn8a promoter region, which increased the histone H4 acetylation and facilitated the Nav1.6 expression in the rodents with L5-VRT."
30736806
reach
"Taken together, all these results demonstrated that proinflammatory cytokine TNF-α induced the hyperexcitability of RGCs by enhancing Nav1.6 currents and protein expression through activating TNFR1, thus contributing to RGC apoptosis in glaucoma."
34419081
reach
"TNF-alpha selectively upregulates Nav1.6 currents in RGCs."
34419081
reach
"These results suggest that TNF-α may selectively enhance Nav1.6 currents."
34419081
reach
"TNF-alpha promotes the combination of p-STAT3/p300 and Scn8a promoter in DRG."
30736806
reach
"Altogether, our study showed that TNF-α, via activating STAT3, mediated epigenetic upregulation of Nav1.6 in DRG and contributed to L5-VRT-induced mechanical allodynia, which provided a novel potential target for the treatment of nerve injury-induced neuropathic pain."
30736806