IndraLab

Statements

SCN9A activates sodium(1+). 4 / 4
| 4
reach
"This t-CSM peptide inhibited CRMP2 SUMOylation, NaV1.7 membrane trafficking, and specifically inhibited NaV1.7 sodium influx in sensory neurons."
29847471
reach
"The SCN9A sodium channel, if active, allows entry of sodium into the cells and then promotes plasma membrane depolarization."
29446526
reach
"SCN9A belongs to the sodium channel gene family and mediates the voltage dependent sodium ion permeability of excitable membranes."
28436151
reach
"Recently, SCN9A gene variants (single amino acid substitutions) have been found in ~ 30% of a cohort of idiopathic SFN patients, producing gain-of-function changes in sodium channel Na (V) 1.7, which is preferentially expressed in small diameter peripheral axons."
22803682