IndraLab

Statements

PRMT7 decreases the amount of HCN1. 3 / 3
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"Molecular analysis demonstrated the colocalization of HCN1 and HCN2 with PRMT7 in the CA1 region in the WT mice, and PRMT7 deficiency in CA1 causes reduced HCN1 protein levels without alteration in the HCN2 protein levels or reduction in the HCN1 mRNA levels."
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"Since PRMT7 knockdown led to a significant reduction in both the protein and transcript levels of SHANK3 in the HEK-293T cells, we hypothesize that PRMT7 deficiency induces an alteration of SHANK3 expression that contributes to the decreased protein level of HCN1."
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"These data suggest that PRMT7 depletion causes a reduction in the HCN1 protein levels."
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