IndraLab

Statements

KCNMA1 binds CTX. 3 / 3
| 3
sparser
"Various fungal indole alkaloids are also able to allosterically regulate binding of CTX to Slo1 channels ( xref )."
20421373
sparser
"In the case of the bovine β1-subunit, the adequate loop conformation appears to be a requisite for BK channel high affinity binding of CTX, as any of the four cysteines contained in the external β1 linker are critical in defining the ability of β1 in enhancing CTX binding ( xref )."
16446507
sparser
"Using the crystal structure of CTX bound to the Kv1.2-Kv2.1 paddle chimera channel to model CTX binding to Slo1, we conclude that there is adequate space for toxin binding within the cage beneath the crown, but that CTX has restricted access across the central opening to reach its binding site ( xref and xref ) ( xref )."
31815672