IndraLab

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U50488 inhibits ITCH. 5 / 5
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"Thus, it is possible that U-50,488 H decreases the activity of histamine sensitive itch specific neurons in the dorsal horn of the spinal cord and thereby restores their ability to inhibit itch."
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"To test whether U-50,488 may inhibit CQ itch via GRPR-independent pathway, we examined its effect on CQ itch using Grpr KO mice and found that i."
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"U-50,488 also attenuated chronic itch induced by 2,4-dinitrofluorobenzene (DNFB), a model for allergic contact dermatitis (ACD), and in mice with dry skin itch induced by an acetone-ether-water (AEW) treatment."
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"To test whether U-50,488 may inhibit CQ itch via GRPR independent pathway, we examined its effect on CQ itch using Grpr KO mice and found that i.t. U-50,488 did not further reduce CQ induced scratching (XREF_SUPPLEMENTARY)."
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"However, U-50,488 attenuated CQ induced itch after siRNA knockdown of Prkca, suggesting that PKCalpha does not mediate KOR activation inhibition of itch (XREF_SUPPLEMENTARY)."
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