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TGFB1 activates MEK. 19 / 20
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"We were therefore interested in whether TGF-beta1 also activates Raf-1 and MEK."
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"Progress in elucidating a role for high levels of FGF2 along with TGF-beta1 to stimulate the PI3K, MEK and ERK, and SMAD2/3 pathways has resulted in a third generation ' defined ' media in which KSR is replaced with BSA or human serum albumin (HSA)."
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"When control and v-ras Ha transduced MEK were treated with TGFbeta1 there was an increase Smad2, 3 and 4, increased phosphorylation of p-Smad2 that followed similar patterns of induction and decay in both cell types (XREF_FIG), and similar nuclear translocation of Smad2/3 in both normal and v-ras Ha transformed keratinocytes (XREF_FIG)."
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"In this paper we show that in cultured hepatic stellate cells TGF-beta1 induces activation of Ras, Raf-1, MEK and MAPK p42 and p44."
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"TGF-beta1 may activate both ALK5 and smad2 and MEK and ERK signaling pathways."
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"Therefore, the ability of activin A and TGFbeta1 to stimulate PI3K and AKT and MEK and ERK signaling was evaluated via western blot."
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"As for capsid expression, Ravichandran et al. ( xref ) found that TGF-β1 activated MEK1/2 and subsequent phosphorylation of Smads, which bound to or increased binding to the JCPyV promoter for VP-1 synthesis."
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"In primary T cells, TGF-beta1 activated the MEK and ERK and p38 MAP kinase pathways, but not the JNK pathway."
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"OPC derived TGF-beta1 activates the MEK and ERK pathway in cerebral endothelium via TGF-beta receptor, and the signaling cascade eventually increases the expression levels of tight-junction proteins to promote the BBB integrity."
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"Investigation of the mechanisms by which TGF-β1 stimulated LIF gene expression revealed MEK and SMAD2/3 activation by TGF-β1 mediate stimulation of LIF gene expression ( xref )."
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"TGF-beta1 was found to activate Raf-1 and MEK, but to a lesser extent than their activation by bFGF or PDGF."
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"We collected conditioned media from MEK and v-ras Ha MEK treated with TGFbeta1 for 24 hrs and analyzed protease activity using gelatin zymography."
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"Knockdown of DA-Raf expression with siRNAs facilitated the activity of MEK and ERK, which were only weakly and transiently activated by TGF-beta1."
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"TGF-beta1 stimulation only weakly and transiently activated MEK and ERK immediately after stimulation, whereas stimulation with FGF2 along with TGF-beta1 caused strong and sustained activation of MEK and ERK."
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"Thus, in hepatic stellate cells TGF-β1 may activate Raf-1, MEK and MAPK not exclusively via Ras or may even activate Raf-1 and Ras independently from each other."
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"We were therefore interested in whether TGF-β1 also activates Raf-1 and MEK."
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"TGF-beta1 derived from oligodendrocyte progenitor cells can activate the MEK and ERK signaling pathway in ECs to promote tight junction protein expression and improve BBB integrity, and knockout of Tgfbr1 in oligodendrocyte progenitor cells leads to cerebral hemorrhage and disruptive BBB in mice."
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"To confirm that TGF-beta1 does not activate ERK or MEK signalling in mast cells, ERK activity was analysed by a kinase assay and ERK phosphorylation was analysed at 1-90 min after addition of TGF-beta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, in hepatic stellate cells TGF-beta1 may activate Raf-1, MEK and MAPK not exclusively via Ras or may even activate Raf-1 and Ras independently from each other."
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