IndraLab

Statements

USP7 activates NFkappaB. 6 / 6
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"Mechanistically, USP7 knockout remarkably increased the sensitivity to BTZ by stabilizing IotakappaBetaalpha and blocking the NF-kappaB pathway."
30024656
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"Our findings support the notion that USP7 activity could be potentially targeted in a substrate selective manner through the development of noncatalytic inhibitors of this deubiquitinase to abrogate NF-kB activity."
32587091
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"In the nucleus, USP7 increases NF-kappaB stability by regulating NF-kappab transcriptional activity [XREF_BIBR]."
33138315
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"Blockade of USP7 enzymatic activity leads to a dramatic increase in the ubiquitination and proteasomal degradation of p65 and profoundly inhibits NF-kappaB transcriptional activity."
27187478
eidos
"We previously demonstrated that the inhibition of USP7 leads to the inhibition of NF-kB directed transcription of pro-inflammatory cytokines such as Il1b , Tnf , and Il6 , identifying USP7 as a potential therapeutic target in inflammatory disease ( 13 ) ."
32587091
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"Several other USP domain DUBs were suggested to act on one or several ubiquitinated proteins in the NF-kappaB activating cascade, including USP4, which may act on TRAF2 and TRAF6 93, 94, and USP7, which enhances NF-kappaB responses by deubiquitinating and stabilising NF-kappaB directly 95."
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