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AKT phosphorylates NOS3 on S1179. 79 / 99
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"Activated SHIP-1 attenuates signaling downstream of PI3 kinase, blunting Akt activation and eNOS Ser1179 phosphorylation by Akt, and thereby decreasing eNOS enzyme activation. xref , xref However, how CRP activates FcγRIIB is not known."
21940940
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"Studies showed that Ser 1179 of eNOS is phosphorylated by protein kinase Akt, which increases electron flux through the reductase domain and NO production."
21559738
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"Akt is downstream from PI 3-kinase and is capable of directly phosphorylating eNOS at Ser 1179 , resulting in its activation [38] ."
21439968
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"Both vascular endothelial growth factor and FSS activate endothelial protein kinase B (PKB) by way of incompletely understood pathway (s), and, in turn, PKB phosphorylates eNOS at Ser 1179, causing its activation."
11287317
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"Moreover, administration of endothelial cells with VEGF induced AKT that can phosphorylate eNOS on Ser 1179."
36731150
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"Along this line, the increase in Akt in response to S1P induced the phosphorylation of eNOS at serine 1179, which first hydroxylated L-arginine to Nω-hydroxy-L-arginine and then oxidized Nω-hydroxy-L-arginine to L-citrulline and NO [184,185]."
36671005
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"HDL stimulation of eNOS entails sequential activation of Src kinase (s), PI3 kinase, Akt kinase and Erk1/2 MAPK, with Akt phosphorylation of Ser1179 of eNOS causing enzyme activation 6."
23023567
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"Akt can phosphorylate eNOS on Ser 1179, and that phosphorylation enhances the enzyme 's ability to generate NO."
18078008
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"Because AMPK and Akt can phosphorylate and activate eNOS at Ser1179 in endothelial cells, XREF_BIBR - XREF_BIBR eNOS phosphorylation was examined in these cultures."
24052499
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"During ischemia, 15 min prior to reperfusion, mice were given geldanamycin, an inhibitor of hsp90 recruitment to eNOS, or LY-294002 an inhibitor of phosphatidylinositol 3-kinase (PI3K), an enzyme that initiates Akt catalysed phosphorylation of eNOS on Ser1179."
17450173
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"Akt inhibition prevented eNOS Ser1179 phosphorylation, whereas inhibition of PKA did not influence Akt and eNOS Ser1179 phosphorylation."
14645258
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"Phosphorylation of eNOS serine 1179 mediated by Akt has been shown to boost its activity ( Fulton et al., 1999; Wu, 2002 ) and, hypoxia-related stimuli, such as VEGF and shear stress, phosphorylate an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17976938
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"For example, eNOS phosphorylation at Ser 1179 by Akt increases NO production [7], while basal phosphorylation of eNOS at Thr 495 reduced its catalytic activity [21]."
24769202
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"Akt-dependent phosphorylation of eNOS at Ser1179 is critical for endothelium-dependent relaxation [ xref ], while phosphorylation at Thr497 is considered inhibitory [ xref ]."
24720460
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"At certain conditions, such as VEGF stimulation, AKT binds with Hsp90 (327-340aa) and phosphorylates eNOS Serine 1179[ xref , xref ]."
28654706
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"Akt kinase phosphorylates eNOS at Ser1179, and is likely to be an important in vivo regulator of eNOS activity [33,34] ."
15261488
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"The molecular mechanism of eNOS activation by apigenin involves continuous eNOS Ser1179 phosphorylation by the PI3K and Akt pathways [XREF_BIBR]."
32326376
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"The serine/threonine kinase Akt (protein kinase B) directly phosphorylates eNOS at Ser1177 (human eNOS) and Ser1179 (bovine eNOS), which increases eNOS activity several-fold [12,13,31]."
12559774
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"Protein kinase Akt can directly activate eNOS by phosphorylating eNOS on serine 1179 (1177), which leads to NO generation [35,36] ."
28870504
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"In addition, Akt-mediated expression and phosphorylation of eNOS at Ser1179 is reduced thereby, impairing endothelial cell-driven NO-related effects on vascular tone and homeostasis [20] ."
36306821
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"Akt also phosphorylates eNOS at Ser-1179, enhancing the production of NO as another mechanism to inhibit apoptosis as described in Section 2.1.4 (Cirino et al., 2003) ."
15031001
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"Phosphorylation of eNOS at Ser 1179 is stimulated by Akt kinase or protein kinase A and results in increased enzyme activity leading to an enhanced NO production, thus allowing to couple extracellular[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16270749
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"The activity of eNOS is reportedly increased not only by translocation of eNOS from cellular membrane to cytosol, but also by Akt-dependent phosphorylation of eNOS at Ser 1179 ( Dimmeler et al., 1999;[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22728282
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"Inhibition of PI3K/Akt and MEK/ERK1/2 prevented phosphorylation of eNOS at Ser1179 by the inhibitors wortmannin and PD98059 ( Fig. 3A ) or by transfection of the dominant-negative Akt cDNA ( Fig. 4 ),[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15358561
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"Akt kinase phosphorylates the eNOS at serine 1179 while increasing NO production [61]."
30030121
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"ENOS is reported to be activated by Akt-dependent phosphorylation of eNOS at Ser 1179 [95] to exert the properties of antiatherosclerosis, including inhibition of smooth muscle cell proliferation, pla[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25956424
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"Insulin promotes the protective cardiovascular endothelial functions by activating Akt, which then phosphorylates endothelial NO synthase (eNOS) in Ser1179, stimulating the production of cardioprotective NO [162]."
35563860
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"Moreover, phosphorylation of human eNOS by Akt at Ser 1179 and subsequent release of NO occur at sub-physiological levels of calcium in endothelial cells [28,29] , suggesting that phosphorylation of e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24407281
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"The serine/threonine protein kinase Akt can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production."
24518819
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"The phosphorylation of eNOS at Ser 1179, and not Thr 495, is mediated by Ca 2+ and the PI3K and Akt pathway [XREF_BIBR]."
20423726
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"Here we show that the serine/threonine protein kinase Akt (protein kinase B) can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production, whereas mutant eNOS (S1179A) is resistant to phosphorylation and activation by Akt."
10376602
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"Akt kinase phosphorylates the eNOS at serine-1179 while increasing NO production [ 61 ]."
30030121
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"Several groups independently reported the important findings that the serine/threonine protein kinase Akt (protein kinase B) directly phosphorylates eNOS on Ser1179 and activates the enzyme, leading t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11551775
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"Full activation of eNOS by S1P requires a pathway comprising G-protein-coupled S1P receptors; pertussis toxin-sensitive G-proteins, especially G-protein beta-gamma subunits that modulate the beta-isof[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18638569
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"At certain conditions, such as VEGF stimulation, AKT binds with Hsp90 (327-340aa) and phosphorylates eNOS Serine 1179 [XREF_BIBR, XREF_BIBR]."
28654706
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"In fact, recent evidence suggests that the phosphorylation of eNOS at Ser 1179 (in the bovine eNOS sequence; equivalent to human eNOS-S 1177 ) by a sequential activation of the phosphoinositide-3-kina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15186944
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"Phosphorylation of eNOS at both Ser1177 and Ser633 in human endothelial cells (Ser1179 and Ser635 in bovine endothelial cells) by Akt, calmodulin-dependent protein kinase II and AMP-activated protein kinase increases eNOS activity [34,42]."
31972507
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"Several groups independently reported the important findings that the serine/threonine protein kinase Akt (protein kinase B) directly phosphorylates eNOS on Ser1179 and activates the enzyme, leading t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11551775
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"Ser1177 (human eNOS) and Ser1179 (bovine eNOS) are phosphorylated by the serine/threonine kinase Akt (protein kinase B) [6,22,23] ."
20363286
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"The resulting increased Akt activation leads to enhanced eNOS phosphorylation at Ser 1177 and/or Ser 1179, thereby increasing the NO synthesizing activity."
30050658
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"Ser1179 phosphorylation of eNOS by the phosphatidylinositol 3-kinase-dependent Akt stimulates its catalytic activity."
17210830
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"Insulin promotes the cardiovascular protective functions of the endothelium including NO production by endothelial NO synthase (eNOS), which it stimulates via Akt kinase which phosphorylates eNOS Ser1179."
19423845
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"Ser1179 phosphorylation of eNOS by the phosphatidylinositol 3-kinase-dependent Akt stimulates its catalytic activity."
17210830
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"It was reported previously that VEGF stimulated phosphorylation of eNOS Ser 1179 by Akt activation, which was required by the formation of the eNOS and Hsp90 heterocomplex [15,16]."
22001744
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"Both vascular endothelial growth factor and FSS activate endothelial protein kinase B (PKB) by way of incompletely understood pathway(s), and, in turn, PKB phosphorylates eNOS at Ser-1179, causing its activation."
11287317
sparser
"The serine/threonine kinase Akt (protein kinase B) directly phosphorylates eNOS at Ser1177 (human eNOS) and Ser1179 (bovine eNOS), which increases eNOS activity several-fold [12,13,31] ."
12559774
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"Akt dependent phosphorylation of eNOS at Ser1179 is critical for endothelium dependent relaxation [XREF_BIBR], while phosphorylation at Thr497 is considered inhibitory [XREF_BIBR]."
24720460
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"XREF_BIBR, XREF_BIBR Akt dependent phosphorylation of eNOS at Ser1179 is essential for endothelium dependent relaxation, 36 whereas phosphorylation at Thr497 is considered inhibitory."
22785174
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"HDL stimulation of eNOS entails sequential activation of Src kinase(s), PI3 kinase, Akt kinase and Erk1/2 MAPK, with Akt phosphorylation of Ser1179 of eNOS causing enzyme activation xref ."
23023567
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"In endothelial cells, eNOS can also be activated by Akt-dependent phosphorylation of eNOS at Ser 1179 ( Dimmeler et al., 1999; Fleming et al., 2001 )."
22728282
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"Taken together, these findings raise the possibility that ceramide may activate eNOS not only by stimulating its dissociation from caveolin-1, but also by increasing eNOS phosphorylation on serine 117[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15642349
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"Full activation of eNOS by S1P requires a pathway comprising G-protein-coupled S1P receptors; pertussis toxin-sensitive G-proteins, especially G-protein beta-gamma subunits that modulate the beta-isof[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18638569
sparser
"Here we show that the serine/threonine protein kinase Akt (protein kinase B) can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production, whereas mutant eNOS (S1179A) is resistant to phosphorylation and activation by Akt."
10376602
sparser
"Akt also phosphorylates eNOS at Ser-1179, enhancing the production of NO as another mechanism to inhibit apoptosis as described in Section 2.1.4 (Cirino et al., 2003) ."
15031001
sparser
"The serine/threonine protein kinase Akt can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production ( xref )."
24518819
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"We now report that LPA treatment of bovine aortic endothelial cells (BAEC) activates eNOS enzyme activity in a pathway that involves phosphorylation of eNOS on serine 1179 by protein kinase Akt."
11939794
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"In endothelial cells, one possible mechanism for the enhanced NO production is an PI3 kinase and PKB/Akt-mediated stimulation of eNOS possibly by synergizing calcium-dependent eNOS phosphorylation at [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19549592
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"Moreover, Akt-dependent phosphorylation of eNOS at Ser1179 has been proved to be essential for endothelium-dependent relaxation [ xref ]."
31805910
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"It has been reported that VEGFA activated PI3K and AKT directly phosphorylates eNOS Ser1179, leading to stimulating NO production, and endothelial migration, proliferation, and capillary like structure formation."
22106098
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"Extensive literature indicates that phosphorylation by Akt on Ser1179 of eNOS leads to augmentation of NO production [ xref , xref ]."
31781259
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"Another mechanism could implicate an inactivation of Akt by HNE [ xref , xref ], the phosphorylation of eNOS by Akt on serine-1179 being required for its activation and NO production [ xref ]."
38397830
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"To confirm that CORM-2-induced NO production was dependent on eNOS phosphorylation, the pharmacological inhibition of Akt was applied to prevent the phosphorylation of eNOS at Ser 1179 ."
27720892
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"Insulin promotes the cardiovascular protective functions of the endothelium including NO production by endothelial NO synthase (eNOS), which it stimulates via Akt kinase which phosphorylates eNOS Ser1179."
19423845
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"The appropriate intracellular localization and distribution of eNOS in PM and Golgi apparatus is necessary for Akt (and agonist)-dependent eNOS phosphorylation on Ser-1179 and is impaired in the cytosolic G2A eNOS (Fulton et al., xref )."
24379783
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"Fulton et al. ( xref ) have demonstrated that the serine/threonine protein kinase Akt (protein kinase B) can directly phosphorylate eNOS on Ser1179 in bovine cells and activate the enzyme."
35137850
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"Moreover, phosphorylation of human eNOS by Akt at Ser 1179 and subsequent release of NO occur at sub-physiological levels of calcium in endothelial cells [28,29] , suggesting that phosphorylation of e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24407281
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"LY294002, an inhibitor of phosphatidylinositol 3-kinase that initiates Akt catalysed phosphorylation of eNOS on Ser1179, was administered 1 h before the induction of SCI; 24 h after SCI sections were taken for histological examination and for biochemical studies."
21496122
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"Phosphorylation of bovine eNOS by AKT and PKB at Ser1179 (Ser1177 in human eNOS) has been shown to upregulate its activity (Fulton et al., 1999; Dimmeler et al., 1999)."
12086862
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"30 It has been reported that the serine/threonine protein kinase Akt can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production."
28619445
reach
"ENOS is reported to be activated by Akt-dependent phosphorylation of eNOS at Ser 1179 [95] to exert the properties of antiatherosclerosis, including inhibition of smooth muscle cell proliferation, pla[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25956424
reach
"Akt kinase phosphorylates eNOS at Ser1179, and is likely to be an important in vivo regulator of eNOS activity [33,34] ."
15261488
reach
"Studies showed that Ser 1179 of eNOS is phosphorylated by protein kinase Akt, which increases electron flux through the reductase domain and NO production."
21559738
sparser
"Moreover, administration of endothelial cells with VEGF induced AKT that can phosphorylate eNOS on Ser 1179."
36731150
sparser
"Akt can phosphorylate eNOS on Ser 1179, and that phosphorylation enhances the enzyme’s ability to generate NO ( xref )."
18078008
reach
"A higher Akt activation enhances eNOS phosphorylation at S1177 and/or S1179, thus resulting in an increase in NO-synthesizing activity."
37569855
sparser
"We now report that LPA treatment of bovine aortic endothelial cells (BAEC) activates eNOS enzyme activity in a pathway that involves phosphorylation of eNOS on serine 1179 by protein kinase Akt."
11939794
reach
"Akt can directly phosphorylate eNOS on serine 1179 (based on the bovine eNOS sequence and equivalent to human eNOS-serine 1177) and activate the enzyme, leading to NO production."
21264179
sparser
"In particular, phosphorylation by Akt on Ser1179 of eNOS leads to enhanced activity of the enzyme and, thus, augments production of nitric oxide [31] ."
21906675
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"30 It has been reported that the serine/threonine protein kinase Akt can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production."
28619445