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AKT phosphorylates NOS3 on S1179. 52 / 53
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"At certain conditions, such as VEGF stimulation, AKT binds with Hsp90 (327-340aa) and phosphorylates eNOS Serine 1179[ xref , xref ]."
28654706
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"It has been reported that VEGFA activated PI3K and AKT directly phosphorylates eNOS Ser1179, leading to stimulating NO production, and endothelial migration, proliferation, and capillary like structure formation."
22106098
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"Akt can directly phosphorylate eNOS on serine 1179 (based on the bovine eNOS sequence and equivalent to human eNOS-serine 1177) and activate the enzyme, leading to NO production."
21264179
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"The serine/threonine protein kinase Akt can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production ( xref )."
24518819
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"The appropriate intracellular localization and distribution of eNOS in PM and Golgi apparatus is necessary for Akt (and agonist)-dependent eNOS phosphorylation on Ser-1179 and is impaired in the cytosolic G2A eNOS (Fulton et al., xref )."
24379783
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"Akt can phosphorylate eNOS on Ser 1179, and that phosphorylation enhances the enzyme’s ability to generate NO ( xref )."
18078008
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"It was reported previously that VEGF stimulated phosphorylation of eNOS Ser 1179 by Akt activation, which was required by the formation of the eNOS and Hsp90 heterocomplex [15,16]."
22001744
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No evidence text available
12501214
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"The resulting increased Akt activation leads to enhanced eNOS phosphorylation at Ser 1177 and/or Ser 1179, thereby increasing the NO synthesizing activity."
30050658
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"Phosphorylation of eNOS at Ser 1179 is stimulated by Akt kinase or protein kinase A and results in increased enzyme activity leading to an enhanced NO production, thus allowing to couple extracellular[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16270749
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"At certain conditions, such as VEGF stimulation, AKT binds with Hsp90 (327-340aa) and phosphorylates eNOS Serine 1179 [XREF_BIBR, XREF_BIBR]."
28654706
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"HDL stimulation of eNOS entails sequential activation of Src kinase (s), PI3 kinase, Akt kinase and Erk1/2 MAPK, with Akt phosphorylation of Ser1179 of eNOS causing enzyme activation 6."
23023567
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"Akt kinase phosphorylates the eNOS at serine-1179 while increasing NO production [ 61 ]."
30030121
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"Akt inhibition prevented eNOS Ser1179 phosphorylation, whereas inhibition of PKA did not influence Akt and eNOS Ser1179 phosphorylation."
14645258
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"Akt dependent phosphorylation of eNOS at Ser1179 is critical for endothelium dependent relaxation [XREF_BIBR], while phosphorylation at Thr497 is considered inhibitory [XREF_BIBR]."
24720460
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"The serine/threonine kinase Akt (protein kinase B) directly phosphorylates eNOS at Ser1177 (human eNOS) and Ser1179 (bovine eNOS), which increases eNOS activity several-fold [12,13,31]."
12559774
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"The serine/threonine protein kinase Akt can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production."
24518819
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"LY294002, an inhibitor of phosphatidylinositol 3-kinase that initiates Akt catalysed phosphorylation of eNOS on Ser1179, was administered 1 h before the induction of SCI; 24 h after SCI sections were taken for histological examination and for biochemical studies."
21496122
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"For example, eNOS phosphorylation at Ser 1179 by Akt increases NO production [7], while basal phosphorylation of eNOS at Thr 495 reduced its catalytic activity [21]."
24769202
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"Akt-dependent phosphorylation of eNOS at Ser1179 is essential for endothelium-dependent relaxation xref ; while phosphorylation at Thr497 is considered inhibitory xref ."
22785174
sparser
"Akt-dependent phosphorylation of eNOS at Ser1179 is critical for endothelium-dependent relaxation [ xref ], while phosphorylation at Thr497 is considered inhibitory [ xref ]."
24720460
sparser
"We now report that LPA treatment of bovine aortic endothelial cells (BAEC) activates eNOS enzyme activity in a pathway that involves phosphorylation of eNOS on serine 1179 by protein kinase Akt."
11939794
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"In particular, phosphorylation by Akt on Ser1179 of eNOS leads to enhanced activity of the enzyme and, thus, augments production of nitric oxide [31] ."
21906675
rlimsp
"Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179). Vasodilator actions of insulin are mediated by activation of endothelial nitric-oxide synthase (eNOS) and subsequent production of NO. Phosphatidylinositol 3-kinase and Akt play important roles in insulin-signaling pathways leading to production of NO in vascular endothelium. Here we dissected mechanisms whereby insulin activates eNOS by using the fluorescent dye DAF-2 to directly measure NO production in single cells. Insulin caused a rapid increase in intracellular NO in NIH-3T3(IR) cells transiently transfected with eNOS. The stimulation of NO production by lysophosphatidic acid (LPA) was abrogated by pretreatment of cells with the calcium chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid. Remarkably, in the same cells, insulin-stimulated production of NO was unaffected. However, cells expressing the eNOS-S1179A mutant (disrupted Akt phosphorylation site) did not produce detectable NO in response to insulin, whereas the response to LPA was similar to that observed in cells expressing wild-type eNOS. Moreover, production of NO in response to insulin was blocked by coexpression of an inhibitory mutant of Akt, whereas the response to LPA was unaffected. Phosphorylation of eNOS at Ser(1179) was observed only in response to treatment with insulin, but not with LPA."
11402048
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"Fulton et al. ( xref ) have demonstrated that the serine/threonine protein kinase Akt (protein kinase B) can directly phosphorylate eNOS on Ser1179 in bovine cells and activate the enzyme."
35137850
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"Akt can phosphorylate eNOS on Ser 1179, and that phosphorylation enhances the enzyme 's ability to generate NO."
18078008
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"The phosphorylation of eNOS at Ser 1179, and not Thr 495, is mediated by Ca 2+ and the PI3K and Akt pathway [XREF_BIBR]."
20423726
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"Because AMPK and Akt can phosphorylate and activate eNOS at Ser1179 in endothelial cells, XREF_BIBR - XREF_BIBR eNOS phosphorylation was examined in these cultures."
24052499
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"Insulin promotes the cardiovascular protective functions of the endothelium including NO production by endothelial NO synthase (eNOS), which it stimulates via Akt kinase which phosphorylates eNOS Ser1179."
19423845
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"Akt dependent phosphorylation of eNOS at Ser1179 is essential for endothelium dependent relaxation 36; while phosphorylation at Thr497 is considered inhibitory 37."
22785174
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"Studies showed that Ser 1179 of eNOS is phosphorylated by protein kinase Akt, which increases electron flux through the reductase domain and NO production."
21559738
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"Both vascular endothelial growth factor and FSS activate endothelial protein kinase B (PKB) by way of incompletely understood pathway (s), and, in turn, PKB phosphorylates eNOS at Ser 1179, causing its activation."
11287317
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"Ser1179 phosphorylation of eNOS by the phosphatidylinositol 3-kinase-dependent Akt stimulates its catalytic activity."
17210830
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"Here we show that the serine/threonine protein kinase Akt (protein kinase B) can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production, whereas mutant eNOS (S1179A) is resistant to phosphorylation and activation by Akt."
10376602
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"Here we show that the serine/threonine protein kinase Akt (protein kinase B) can directly phosphorylate eNOS on serine 1179 and activate the enzyme, leading to NO production, whereas mutant eNOS (S1179A) is resistant to phosphorylation and activation by Akt."
10376602
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"The molecular mechanism of eNOS activation by apigenin involves continuous eNOS Ser1179 phosphorylation by the PI3K and Akt pathways [XREF_BIBR]."
32326376
sparser
"Insulin promotes the cardiovascular protective functions of the endothelium including NO production by endothelial NO synthase (eNOS), which it stimulates via Akt kinase which phosphorylates eNOS Ser1179."
19423845
sparser
"Moreover, Akt-dependent phosphorylation of eNOS at Ser1179 has been proved to be essential for endothelium-dependent relaxation [ xref ]."
31805910
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"Several groups independently reported the important findings that the serine/threonine protein kinase Akt (protein kinase B) directly phosphorylates eNOS on Ser1179 and activates the enzyme, leading t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11551775
sparser
"Both vascular endothelial growth factor and FSS activate endothelial protein kinase B (PKB) by way of incompletely understood pathway(s), and, in turn, PKB phosphorylates eNOS at Ser-1179, causing its activation."
11287317
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"During ischemia, 15 min prior to reperfusion, mice were given geldanamycin, an inhibitor of hsp90 recruitment to eNOS, or LY-294002 an inhibitor of phosphatidylinositol 3-kinase (PI3K), an enzyme that initiates Akt catalysed phosphorylation of eNOS on Ser1179."
17450173
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"Akt kinase phosphorylates the eNOS at serine 1179 while increasing NO production [61]."
30030121
sparser
"Studies showed that Ser 1179 of eNOS is phosphorylated by protein kinase Akt, which increases electron flux through the reductase domain and NO production."
21559738
reach
"XREF_BIBR, XREF_BIBR Akt dependent phosphorylation of eNOS at Ser1179 is essential for endothelium dependent relaxation, 36 whereas phosphorylation at Thr497 is considered inhibitory."
22785174
reach
"We now report that LPA treatment of bovine aortic endothelial cells (BAEC) activates eNOS enzyme activity in a pathway that involves phosphorylation of eNOS on serine 1179 by protein kinase Akt."
11939794
sparser
"The serine/threonine kinase Akt (protein kinase B) directly phosphorylates eNOS at Ser1177 (human eNOS) and Ser1179 (bovine eNOS), which increases eNOS activity several-fold [12,13,31] ."
12559774
sparser
"Several groups independently reported the important findings that the serine/threonine protein kinase Akt (protein kinase B) directly phosphorylates eNOS on Ser1179 and activates the enzyme, leading t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11551775
reach
"Phosphorylation of bovine eNOS by AKT and PKB at Ser1179 (Ser1177 in human eNOS) has been shown to upregulate its activity (Fulton et al., 1999; Dimmeler et al., 1999)."
12086862
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"Activated SHIP-1 attenuates signaling downstream of PI3 kinase, blunting Akt activation and eNOS Ser1179 phosphorylation by Akt, and thereby decreasing eNOS enzyme activation. xref , xref However, how CRP activates FcγRIIB is not known."
21940940
sparser
"Ser1179 phosphorylation of eNOS by the phosphatidylinositol 3-kinase-dependent Akt stimulates its catalytic activity."
17210830
sparser
"Extensive literature indicates that phosphorylation by Akt on Ser1179 of eNOS leads to augmentation of NO production [ xref , xref ]."
31781259
sparser
"HDL stimulation of eNOS entails sequential activation of Src kinase(s), PI3 kinase, Akt kinase and Erk1/2 MAPK, with Akt phosphorylation of Ser1179 of eNOS causing enzyme activation xref ."
23023567