IndraLab

Statements

UCHL1 deubiquitinates NTRK2. 5 / 5
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"We provide evidence that UCH-L1 can deubiquitinate TrkB directly."
28500221
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"UCH-L1 mediates the deubiquitylation of TrkB by cleaving ubiquitin (probably polyubiquitin chains) and thereby inhibits TrkB degradation."
33483467
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"Deubiquitination of TrkB by the DUB UCHL1 has been reported, which maintains expression of the receptor on the cell surface [XREF_BIBR]."
29543760
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"Together, our results suggest that the ubiquitination of TrkB is a mechanism that controls its downstream signaling pathways via the regulation of its endocytosis and postendocytic trafficking and that UCH-L1 mediates the deubiquitination of TrkB and could be a potential target for the modulation of hippocampus dependent memory."
28500221
ubibrowser
"Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on TrkB"
28500221