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UCHL1 deubiquitinates NTRK2. 7 / 7
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"Ubiquitin C-Terminal Hydrolase L1 (<span class="match term0">UCH-L1</span>) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on <span class="match term1">TrkB</span>"
28500221
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"Deubiquitination of TrkB by the DUB UCHL1 has been reported, which maintains expression of the receptor on the cell surface [XREF_BIBR]."
29543760
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"We provide evidence that UCH-L1 can deubiquitinate TrkB directly."
28500221
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"Together, our results suggest that the ubiquitination of TrkB is a mechanism that controls its downstream signaling pathways via the regulation of its endocytosis and postendocytic trafficking and that UCH-L1 mediates the deubiquitination of TrkB and could be a potential target for the modulation of hippocampus dependent memory."
28500221
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"There is also evidence that UCHL1 can deubiquitinate tropomyosin receptor kinase B (TrkB) directly in mouse hippocampus."
36681249
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"Blockage of UCHL1 regulated deubiquitination of TrkB resulted in the increased degradation of surface TrkB and decreased activation of TrkB and its downstream signaling pathways (Guo et al., 2017)."
36681249
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"UCH-L1 mediates the deubiquitylation of TrkB by cleaving ubiquitin (probably polyubiquitin chains) and thereby inhibits TrkB degradation."
33483467