IndraLab

Statements

UCHL1 deubiquitinates NTRK2. 6 / 7
1 | 6
reach
"Deubiquitination of TrkB by the DUB UCHL1 has been reported, which maintains expression of the receptor on the cell surface [XREF_BIBR]."
29543760
reach
"We provide evidence that UCH-L1 can deubiquitinate TrkB directly."
28500221
reach
"Together, our results suggest that the ubiquitination of TrkB is a mechanism that controls its downstream signaling pathways via the regulation of its endocytosis and postendocytic trafficking and that UCH-L1 mediates the deubiquitination of TrkB and could be a potential target for the modulation of hippocampus dependent memory."
28500221
reach
"There is also evidence that UCHL1 can deubiquitinate tropomyosin receptor kinase B (TrkB) directly in mouse hippocampus."
36681249
reach
"Blockage of UCHL1 regulated deubiquitination of TrkB resulted in the increased degradation of surface TrkB and decreased activation of TrkB and its downstream signaling pathways (Guo et al., 2017)."
36681249
reach
"UCH-L1 mediates the deubiquitylation of TrkB by cleaving ubiquitin (probably polyubiquitin chains) and thereby inhibits TrkB degradation."
33483467