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CYLD activates RIPK1. 13 / 14
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"Then, we found that RIP3 accounts for shikonin induced activation of MLKL, and activated MLKL reversely up-regulates the protein level of CYLD and promotes the activation of RIP1 and RIP3."
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"An alternative explanation for the embellished necroptotic sensitivity observed in casp8 deficient cells has been raised by Ting and colleagues, observing that casp8 mediated cleavage of the E3 ubiquitin ligase CYLD enhances RIP1 and RIP3 dependent necroptosis [XREF_BIBR]."
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"In addition we show that optineurin is required for CYLD mediated deubiquitnation of RIP."
21408173
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"CYLD is an essential mediator of RIPK1 - and RIPK3-dependent necroptosis [ 145 ] ."
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"In contrast, overexpression of CYLD caused downregulation of RIPK1 in Mel-CV and ME1007 cells, which was nevertheless reversed by the treatment with the proteasome inhibitor MG132 (XREF_FIG), substantiating that downregulation of RIPK1 expression by CYLD is mediated by the proteasomal degradation XREF_BIBR."
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"Rather than inhibiting RipK1 degradation, knock-down of CYLD and/or A20 appeared to enhance the degradation of RipK1, suggesting that CYLD and A20 promote maintenance of RipK1."
29789521
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"These observations strongly suggest that in ATLL cells, either viral encoded oncogenic proteins or mutations sustain the early cell death checkpoint by driving multiple IKKs to phosphorylate and suppress CYLD in order to prevent RIPK1 from becoming a death-signaling molecule (Fig. 8a)."
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"Cylindromatosis (CYLD), an enzyme that deubiquitinates K63 specifically, can mediate the RIPK1 deubiquitinating process to expedite the complex IIb-forming process, covering pro-caspase-8, FADD and TRADD [33]."
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"CYLD destabilizes complex I and allows RIP1 to dissociate from the plasma membrane."
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"CYLD Is Critical for Protection Against the Apoptosis Inducing Potential of RIPK1 in a Subset of Melanoma Cells."
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"Cointroduction of CYLD or RIPK1 siRNA abolished apoptosis induced by introduction of miR-99b-3p mimics (XREF_FIG), confirming that downregulation of CYLD and subsequent upregulation of RIPK1 are responsible for induction of apoptosis by the mimics."
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"CYLD and A20 function as deubiquitination enzymes to inhibit IKK by targeting RIP1 upstream of IKK, while CUEDC2 acts as an adaptor protein to keep IKK in an inactivated status by recruiting a phospha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28499869
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"Mouse RIP3, RIP1, MLKL, and CYLD siRNAs were synthesized by GenePharma : RIP3-1 (cccgacgaugucuucugucaa), RIP3-2 (cuccuuaaagucaauaaacau), RIP1-1 (ccacuagucugacugauga), RIP1-2 (ucaccaauguugcaggaua), CYLD-1 (uccauugaggauguaaauaaa), CYLD-2 (aaggguugaaccauuguuaaa), MLKL-1 (gagauccaguucaacgaua), and MLKL-2 (uaccaucaaaguauucaacaa)."
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