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UCHL1 activates NOX4. 8 / 14
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"Moreover, Uchl1 promotes H O production by upregulating NADPH oxidase 4 (NOX4) activity through deubiquitination in the migration process of cancer cells (Kim et al., 2015), as well as in angiogenesis (Song et al., 2018)."
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"In summary, we demonstrated that UCH-L1 promotes H 2 O 2 generation by up-regulating NOX4 activity through deubiquitination, and that H 2 O 2, so produced, plays an important role in cell invasion in vitro by regulating the upstream kinase Akt."
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"Here we demonstrated that UCH-L1-dependent NOX4 is involved in VEGF mediated endothelial responses through VEGFR2, suggesting that UCH-L1 may be a novel potential therapeutic target in the treatment o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results suggest that UCH-L1 restores H 2 O 2 -generating activity of NOX4 through deubiquitination."
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"To verify whether UCH-L1 is involved in NOX4-mediated HO generation in HUVEC, we examined NOX4 activation by UCH-L1."
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"Because silencing UCH-L1 inhibited the phosphorylation of VEGFR, a signal for angiogenesis, this finding provides another evidence that UCH-L1 promotes ROS generation in HUVECs, and plays a key role i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"UCH-L1 induced active NOX4 by deubiquitination of NOX4, and then increased ROS which induce angiogenesis in HUVECs."
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"The present study clearly shows that UCH-L1 increases H 2 O 2 level in HUVECs as well as in melanoma cells by activating NOX4 via deubiquitination [13]."
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