IndraLab

Statements

HDAC inhibits BAP1. 4 / 4
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"We then investigated whether HDAC inhibition could reverse the phenotypic consequences of BAP1 loss : loss of melanocytic differentiation and acquisition of the class 2 gene expression profile."
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"Histone deacetylase (HDAC) inhibitors have been shown to reverse the phenotypic effects of BAP1 loss by inducing morphologic differentiation and transition from a high-risk to a low-risk gene expression profile in uveal melanoma cells."
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"The Bap1 deficient phenotype can be rescued with human BAP1, by pharmacologic inhibition of histone deacetylase (HDAC) activity or by specific knockdown of Hdac4."
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"Histone deacetylase (HDAC) inhibitors, such as the readily available valproic acid, can reverse this effect of BAP1 loss and may play a role in treated patients with high-risk class 2 uveal melanomas in an adjuvant setting prior to the emergence of overt metastatic disease [XREF_BIBR]."
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