IndraLab

Statements

Hydroxychloroquine activates ABT-737. 3 / 3
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"Given recent studies demonstrating that autophagy is a resistance mechanism to multiple therapeutic agents in the setting of apoptotic inhibition, we hypothesized that hydroxychloroquine (HCQ), an anti-malarial drug that inhibits autophagy, will increase cytotoxicity of ABT-737."
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"However, HCQ enhanced the cytotoxicity of ABT-737 compared to each agent alone at multiple ABT-737 concentrations (P < 0.01) supporting plans for further assessment in an in vivo model (which is described below)."
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"In an effort to develop a therapeutic regimen for future clinical studies, our results further demonstrated that HCQ, as an inhibitor of autophagy, increased cytotoxicity of ABT-737 in vitro (XREF_FIG) and in vivo (XREF_FIG)."
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