IndraLab
Statements
USP13 activates Virus Replication. 2 / 2
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2
eidos
"Our results demonstrate that USP13 is hijacked to maintain nsp13 expression and the inhibitory role of nsp13 in regulating type I IFN production , and USP13 inhibitor could be employed to suppress virus replication by targeting nsp13 for degradation thereby disrupting its inhibitory role in regulating type I IFN production ."
eidos
"Moreover , depletion of USP13 or treatment with USP13 inhibitor relieves the inhibitory role of nsp13 for type I IFN response and suppresses virus replication in host cells , suggesting that USP13 inhibitor could be employed to suppress virus replication by targeting nsp13 for degradation ."