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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP5 activates calcium(2+). 2 / 2

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"This would add to the already elevated level of USP5, which would enhance the deubiquitinylation of Ca 3.2 and further potentiate the expression of the channel in the plasma membrane.Asparagine (N)-linked glycosylation is another type of post-translational modification that has been reported to potentially contribute to peripheral painful diabetic neuropathy."

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"When the nerve is damaged , USP5 enhances the deubiquitination of the Cav3.2 channel in the dorsal horn , increasing T-type calcium current , which in turn causes pain hypersensitivity ( Gadotti et al ., 2015 ; Gadotti and Zamponi , 2018 ; Ozaki et al ., 2018 ) ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...