IndraLab

Statements

CYLD leads to the dephosphorylation of AKT. 3 / 3
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"The finding that CYLD interacts with Akt and suppresses ubiquitination of Akt prompted us to determine whether CYLD prevents phosphorylation of Akt in response to growth factor stimulation."
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"CYLD repression by miR-130b restores Akt ubiquitination and activation, GSK3beta and FoxO3a phosphorylation, FoxO3a removal from Bim promoter as well as Bim downregulation during 6-OHDA administration."
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"Conversely, restoration of wild-type CYLD, but not the C601A mutant, into CYLD knockdown cancer cells reversed IGF-1-induced phosphorylation of Akt, suggesting that the enzymatic activity of CYLD plays a critical role in suppressing growth factor induced phosphorylation of Akt (XREF_FIG)."
23300340