IndraLab

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ErGPCR increases the amount of USP1. 2 / 2
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"Correlated with its location, the truncation of the N-terminal extracellular region of ErGPCR (OVErGPCR increment20-197 aa) caused a decrease in the 20E induced transcript levels of EcRB1, BrZ2, HHR3, and USP1 compared with the full-length OVErGPCR."
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"Knockdown of ErGPCR repressed the binding of EcRB1 to EcRE thus blocked 20E induced expression of EcRB1, USP1, HHR3, BrZ2, and E75B in the cell line and larvae, which resulted in blocking the 20E genomic pathway, thereby inhibiting metamorphosis."
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