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BAP1 decreases the amount of SLC7A11. 30 / 30
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"Studies have shown that BAP1 inhibits the expression of solute carrier family 7 member 11 (SLC7A11) by decreasing H2Aub occupancy on it."
34405018
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"SLC7A11 is an essential BAP1 target in human cancers, and BAP1 represses SLC7A11 expression via reducing H2Aub occupancy on SLC7A11 promoter in a deubiquitinating dependent manner [XREF_BIBR, XREF_BIBR]."
33425217
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"In this manner, BAP1 reduces SLC7A11 expression and cysteine uptake, leading lipid peroxidation upregulation and the ferroptosis induction (71)."
33446574
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"Although the precise mechanism by which BAP1 induces SLC7A11 repression needs further elucidation, it was proposed that BAP1, a H2A deubiquitinase, represses SLC7A11 expression by regulating the levels of H2A ubiquitination (H2Aub) on the SLC7A11 promoter (Figure 2) [41]."
32413317
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"Specifically, our study suggests a model in which the tumor suppressor BAP1 normally functions to repress the expression of SLC7A11 at least partly by deubiquitinating H2Aub on SLC7A11, thereby inhibiting cystine uptake into cells and rendering them more sensitive to ferroptosis."
30202049
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"Functional studies reveal that BAP1 decreases H2Aub occupancy on the SLC7A11 promoter and represses SLC7A11 expression in a deubiquitinating dependent manner, and that BAP1 inhibits cystine uptake by repressing SLC7A11 expression, leading to elevated lipid peroxidation and ferroptosis."
30202049
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"Epigenetically, BAP1 inhibits SLC7A11 expression through de-ubiquitinating H2A [13], while chromatin remodeling factor ARID1A increases SLC7A11 expression [14]."
34385181
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"In addition, erastin potently induced SLC7A11 expression in BAP1 deficient cells (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY), suggesting that BAP1 represses the basal expression of SLC7A11 and that erastin induces SLC7A11 expression likely through BAP1 independent mechanisms."
30202049
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"BRCA1-associated protein 1 (BAP1) [18], the crucial constituent of the deubiquitinase complex, attenuated the initiation and extension of SLC7A11 transcription by deubiquitinating histone 2A, while the steady-state levels and half-life of SLC7A11 were improved by combination with the ovarian tumor family member deubiquitinase (OTUB1) [19]."
32908642
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"Both BAP1 and PRC1 (the main H2Aub ubiquitin ligase) inhibit the expression of SLC7A11 [XREF_BIBR]."
33574983
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"In addition, it 's been found that in renal cancer cell line, as a nuclear deubiquitinating enzyme, the tumour suppressor BRCA1 associated protein 1 decreases SLC7A11 expression, thereby causing lipid peroxidation and ferroptosis [XREF_BIBR]."
33024562
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"Similarly, BAP1, an epigenetic regulator and tumor suppressor mutated in various types of cancer, can downregulate the transcription of SLC7A11 and thus potentiate ferroptosis (Zhang et al., 2018)."
32294465
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"Recently, it has been found that BAP1 can inhibit the expression of SLC7A11 to suppress the uptake of cystine by deubiquitinating histone 2A on the SLC7A11 promoter."
33665167
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"As a deubiquitinating enzyme, BAP1 inhibits the expression of SLC7A11 by reducing the ubiquitination of H2A to inhibit the activity of SLC7A11 promoter (23)."
32944533
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"Finally, we show that, while BAP1 decreases whereas PRC1 (a major H2Aub ubiquitin ligase) increases H2Aub binding on the SLC7A11 promoter, both BAP1 and PRC1 represses SLC7A11 expression, suggesting that a dynamic regulation of H2Aub is important for SLC7A11 repression."
30907299
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"Our study suggested that BAP1 represses SLC7A11 expression through BAP1 mediated H2Aub deubiquitination on SLC7A11."
30202049
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"The mechanism may be that BAP1 represses the transcription of SLC7A11 by reducing histone 2A ubiquitination (H2Aub) on the SLC7A11 gene (49)."
35434035
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"We next sought to determine whether BAP1 promotes ferroptosis by mediating repression of SLC7A11 expression."
30202049
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"In terms of cancer metabolism, the tumor suppressor BRCA1 associated protein-1 (BAP1) inhibits SLC7A11 expression in a de-ubiquitin-dependent manner, resulting in lipid peroxidation and ferroptosis."
33330074
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"We recently discovered that tumor suppressor BAP1, a H2A deubiquitinase, represses SLC7A11 expression by reducing H2A ubiquitination (H2Aub) on the SLC7A11 promoter."
30907299
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"p53 binds to the SLC7A11 promoter, directly suppressing its transcription; the nuclear deubiquitinase (DUB) BAP1 represses SLC7A11 transcription by removing histone 2A ubiquitination from the SLC7A11 promoter; and KEAP1 represses SLC7A11 transcription through degrading NRF2, a master transcription factor of antioxidant response and regulator of SLC7A11."
30987975
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"By removing ubiquitin from H2Aub on the SLC7A11, BAP1 can repress SLC7A11 expression [89]."
32103754
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"However, restoring BAP1 in p53 deficient cells still inhibited SLC7A11 expression (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY), and the fold change in SLC7A11 expression by BAP1 restoration in p53 deficient cells was similar to that in p53-proficient cells (XREF_SUPPLEMENTARY), suggesting that BAP1 represses SLC7A11 expression independent of p53."
30202049
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"Two key tumor suppressor proteins, p53 (TP53) (Jiang et al., 2015) and BAP1 (Zhang et al., 2018a), independently suppress SLC7A11 expression."
32302583
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"Further mechanistic studies demonstrated that BAP1 suppresses SLC7A11 expression partly by deubiquitinating histone 2A ubiquitination to promote ferroptosis."
33499222
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"Functional studies reveal that BAP1 decreases H2Aub occupancy on the SLC7A11 promoter and represses SLC7A11 expression in a DUB dependent manner and that BAP1 inhibits cystine uptake through repressing SLC7A11 expression, leading to elevated lipid peroxidation and ferroptosis."
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"Collectively, our data strongly suggested that BAP1 promotes ferroptosis mainly through BAP1 mediated repression of SLC7A11 expression."
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"Importantly, restoration of BAP1 WT, but not its C91A mutant, in BAP1 CRISPR knockout (KO) (sgBAP1) 786-O cells decreased SLC7A11 expression to a level similar to that in 786-O control cells (XREF_FIG)."
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"In MPM, the abundance of PUFAs is dependent on the level of acyl-CoA synthetase long-chain family member 4 (ACSL4) expression, which is activated by YAP and TAZ, while BAP1 inhibits the expression of the scavenger SLC7A11 [XREF_BIBR]."
| PMC
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"BAP1 suppresses SLC7A11 expression and reduces H2Aub occupancy on the SLC7A11 promoter."
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