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BAP1 decreases the amount of SLC7A11. 102 / 102
| 102
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"Together, our data showed that BAP1 decreases whereas PRC1 increases H2Aub binding on the SLC7A11 promoter, but both BAP1 and PRC1 represses SLC7A11 expression, thus supporting a model that a balance between H2A ubiquitination and de-ubiquitination might be important for maintaining SLC7A11 repression (see Discussion)."
30907299
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"Thus, our data are in line with the model from Drosophila studies and suggest a hypothesis that BAP1 and PRC1 coordinately repress SLC7A11 expression through dynamic regulation of H2Aub levels on the SLC7A11 promoter."
30907299
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"Indeed, p53 or the histone deubiquitinating enzyme BAP1 inhibiting SLC7A11 expression promotes ferroptosis (124, 125)."
35620395
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"In addition, it 's been found that in renal cancer cell line, as a nuclear deubiquitinating enzyme, the tumour suppressor BRCA1 associated protein 1 decreases SLC7A11 expression, thereby causing lipid peroxidation and ferroptosis [XREF_BIBR]."
33024562
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"SLC7A11 is an essential BAP1 target in human cancers, and BAP1 represses SLC7A11 expression via reducing H2Aub occupancy on SLC7A11 promoter in a deubiquitinating dependent manner [XREF_BIBR, XREF_BIBR]."
33425217
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"Another study (Zhang Y. et al., 2018) suggests that the tumor suppressor BRCA1-associated protein 1 (BAP1) also promotes ferroptosis by downregulating the expression of SLC7A11."
35720113
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"Studies have shown that BAP1 inhibits the expression of solute carrier family 7 member 11 (SLC7A11) by decreasing H2Aub occupancy on it."
34405018
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"Studies have found that SLC7A11 is a key target gene of BAP1, and BAP1 inhibits the expression of SLC7A11 by reducing H2Aub on the SLC7A11 promoter, promoting the occurrence of ferroptosis, and then inhibiting tumor growth."
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"BAP1 reduces H2Aub occupancy on the SLC7A11 promoter and represses SLC7A11 expression in a deubiquitin-dependent, but not NFE2L2- and ATF4-dependent manner [87]."
36551253
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"The mechanism may be that BAP1 suppresses SLC7A11 transcription by reducing histone 2A ubiquitination (H2Aub) on the SLC7A11 gene."
37299036
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"In this manner, BAP1 reduces SLC7A11 expression and cysteine uptake, leading lipid peroxidation upregulation and the ferroptosis induction (71)."
33446574
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"Our analysis showed that BAP1 restoration in control UMRC6 cells decreased H2Aub and SLC7A11 levels to similar degrees to that in NRF2 or ATF4 KO UMRC6 cells, suggesting that BAP1 regulates SLC7A11 expression independent of NRF2 or ATF4.PRC1 regulates SLC7A11 expression and h2aub occupancy on the SLC7A11 promoterSince our study suggested that BAP1 represses SLC7A11 expression through regulating H2Aub CELL CYCLE777Figure 1."
30907299
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"BAP1 represses solute carrier family 7 member 11 (SLC7A11) expression by reducing H2A ubiquitination of the SLC7A11 promoter, resulting in lipid peroxidation and ferroptosis (Zhang et al., 2019)."
39748950
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"Zhang et al. demonstrated that BAP1 could inhibit the expression of SLC7A11 by decreasing the occupancy of the H2Aub promoter, resulting in inhibited intracellular cystine uptake and increased lipid peroxidation levels (48)."
36726381
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"The mechanism how BAP1 suppresses SLC7A11 expression may partially attribute to the deubiquitinating H2A ubiquitination (H2Aub) on SLC7A11 [103]."
38089453
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"Recently, it has been found that BAP1 can inhibit the expression of SLC7A11 to suppress the uptake of cystine by deubiquitinating histone 2A on the SLC7A11 promoter."
33665167
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"On the contrary, BAP1 and PRC1 deubiquitinate H2A in the promoter of SLC7A11 and inhibit the transcription of SLC7A11 [95]."
38654314
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"Finally, we show that, while BAP1 decreases whereas PRC1 (a major H2Aub ubiquitin ligase) increases H2Aub binding on the SLC7A11 promoter, both BAP1 and PRC1 represses SLC7A11 expression, suggesting that a dynamic regulation of H2Aub is important for SLC7A11 repression."
30907299
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"In terms of cancer metabolism, the tumor suppressor BRCA1 associated protein-1 (BAP1) inhibits SLC7A11 expression in a de-ubiquitin-dependent manner, resulting in lipid peroxidation and ferroptosis."
33330074
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"Although the precise mechanism by which BAP1 induces SLC7A11 repression needs further elucidation, it was proposed that BAP1, a H2A deubiquitinase, represses SLC7A11 expression by regulating the levels of H2A ubiquitination (H2Aub) on the SLC7A11 promoter (Figure 2) [41]."
32413317
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"Notably, it has been reported that the expression of SLC7A11 is inhibited by BAP1 [29] providing an explanation why loss of BAP1 is a key prognosticator for metastatic UM and suggesting that induction of ferroptosis in metastatic UM is a promising treatment option.Here we report the generation of patient-derived UM spheroids which allow UM metastasis formation in zebrafish upon engraftment of spheroid cells into the circulation of zebrafish larvae."
37321991
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"BAP1 suppresses the expression of SLC7A11 to inhibit cystine uptake, leading to lipid peroxidation and ferroptosis."
38267442
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"Human tumor-associated mutations in BAP1 do not inhibit the expression of SLC7A11 and do not suppress tumors via promoting ferroptosis [50]."
38267442
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"The tumour suppressor BAP1 enhances ferroptosis by regulating the expression of cystine transporter SLC7A11, thus improving the control of tumour growth [180, 181]."
36600313
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"Additionally, its normalization by reintroduction of BAP1 but not BAP1 , suggests BAP1-mediated repression of Slc7a11 expression requires BAP1’s DUB activity (Fig. 5c)."
37740028
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"This BAP1-initiated pathway includes regulation of mitochondrial metabolism and repressing Slc7a11 expression."
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"Indeed, several tumor suppressor genes, including p53 ( Jiang et al., 2015 ; Jennis et al., 2016 ; Wang et al., 2016 ; Xie et al., 2017 ), BRCA1-associated protein 1 ( BAP1 ) ( Zhang et al., 2018b ), [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33217331
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"BAP1-mediated deubiquitination dissociates H2Aub from the SLC7A11 promoter and inhibits the expression of SLC7A11, which subsequently suppresses cystine uptake and induces ferroptosis."
37714846
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"BRCA1-Associated Protein 1 (BAP1) decreases H2Aub occupancy on the SLC7A11 promoter and represses SLC7A11 expression in a deubiquitinating-dependent manner [9]."
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"Collectively, our data strongly suggested that BAP1 promotes ferroptosis mainly through BAP1 mediated repression of SLC7A11 expression."
30202049
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"We showed that BAP1 reduces H2Aub occupancy on the SLC7A11 promoter and gene body, represses SLC7A11 expression and SLC7A11mediated cystine import, and sensitizes cancer cells to erastin- or cystine depletion induced ferroptosis."
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"SLC7A11 also plays an important role in RCC development; both p53 and BRCA1-associated protein 1 (BAP1) can inhibit SLC7A11 expression, thus promoting ferroptosis to suppress RCC development [23,24,25]."
39335103
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"Both p53 and BRCA1-associated protein 1 (BAP1) inhibit the expression of SLC7A11, thereby suppressing the development of RCC by promoting ferroptosis [15, 119, 292, 293]."
37739961
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"In MPM, the abundance of PUFAs is dependent on the level of acyl-CoA synthetase long-chain family member 4 (ACSL4) expression, which is activated by YAP and TAZ, while BAP1 inhibits the expression of the scavenger SLC7A11 [XREF_BIBR]."
| PMC
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"In human cancers, BAP1 reduces H2Aub occupancy on the SLC7A11 promoter and suppresses SLC7A11 expression in a deubiquitination-dependent manner and then inhibits cystine uptake, promotes lipid peroxidation, and finally induces ferroptosis."
31908494
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"Currently it is challenging to definitively establish whether an epigenetic modulator regulates target gene expression via corresponding histone mark changes (e.g., whether BAP1 or PRC1 represses SLC7A11 expression via H2Aub de-ubiquitination on the SLC7A11 promoter)."
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"BRCA1-associated protein 1 (BAP1) and p53 can also suppress cystine absorption and the level of GSH by inhibiting the expression of SLC7A11, leading to ROS accumulation and ferroptosis (Jiang et al., 2015a; Zhang et al., 2018a)."
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"BAP1 and PRC1 coordinately repress SLC7A11 expression through regulation of H2Aub levels on the SLC7A11 promoter."
30907299
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"BAP1 inhibits the expression of SLC7A11 by BAP1-mediated H2Aub deubiquitination on the promoter of SLC7A11, resulting in elevated lipid peroxidation and ferroptosis (Zhang et al., 2018a)."
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"Zhang et al69 found that BAP1 inhibited SLC7A11 expression at a certain degree through H2Aub deubiquitination, thereby inhibiting cystine uptake and upregulating cells’ sensitivity ferroptosis."
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"For example, ATF3, ATF4, BACH1, PRC1, BAP1, and BECN1 can inhibit the expression of SLC7A11 (19–23); Knockdown of metallothionein (MT-1G) accelerated GSH consumption (24)."
38511140
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"Studies have shown that the anti-tumor effect of BAP1 is partly due to the ubiquitination of H2A on the promoter of SLC7A11, thus inhibiting the expression of SLC7A11 and inducing ferroptosis [100]."
38475936
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"Further mechanistic studies demonstrated that BAP1 suppresses SLC7A11 expression partly by deubiquitinating histone 2A ubiquitination to promote ferroptosis."
33499222
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"Recent research has shown that the protein BAP1 reduces H2Aub occupancy on the regulator of the ferroptosis inhibitor SLC7A11 and suppresses the expression of SLC7A11 in a deubiquitinating-dependent way and that increased lipid peroxidation and ferroptosis are the direct results of BAP1's suppression of SLC7A11 expression, which impairs cystine absorption [24]."
36060648
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"Moreover, BAP1 inhibited the expression of solute carrier family 7 member 11 (SLC7A11) by deubiquitinating histone 2 A (H2Aub) on the promoter of SLC7A11."
38816686
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"Interestingly, Zhang et al. recently found that the tumor suppressor BRCA1 related protein 1 (BAP1) inhibited the transcriptional expression of SLC7A11 by deubiquitination of the ubiquitin histone H2A (H2Aub) on the SLC7A11 promoter, Histone ubiquitination is a type of post-translational modification of histones."
38816686
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"Additionally, it has been discovered that the BRCA1-associated protein 1 tumor suppressor acts as a nuclear deubiquitinating enzyme and lowers SLC7A11 expression in renal cancer cell lines, leading to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38631667
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"BAP1 inhibited the expression of SLC7A11 through deubiquitination."
38816686
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"Both BAP1 and PRC1 (the main H2Aub ubiquitin ligase) inhibit the expression of SLC7A11 [XREF_BIBR]."
33574983
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"BAP1, a tumour suppressor, has been shown to reduce SLC7A11 expression and promote ferroptosis by regulating H2A ubiquitination at the SLC7A11 promoter (Zhang et al., 2019)."
37318883
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"The tumor suppressor BRCA1‐associated protein 1 (BAP1) represses cystine uptake by inhibiting SLC7A11 expression and promotes ferroptosis."
38178583
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"As illustrated by the CO-IP assay, overexpression of BAP1 reduced the ubiquitination level of SLC7A11, whereas the addition of G5 increased the ubiquitination level (Fig. 4D and E; CON vs. LPS, p < 0.0001; NC(+) vs. BAP1(+), p = 0.0002; BAP1(+) vs. BAP1(+) + G5, p < 0.0001)."
38816686
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"We next sought to determine whether BAP1 promotes ferroptosis by mediating repression of SLC7A11 expression."
30202049
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"Functional studies reveal that BAP1 decreases H2Aub occupancy on the SLC7A11 promoter and represses SLC7A11 expression in a DUB dependent manner and that BAP1 inhibits cystine uptake through repressing SLC7A11 expression, leading to elevated lipid peroxidation and ferroptosis."
30202049
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"BAP1 suppresses SLC7A11 expression and reduces H2Aub occupancy on the SLC7A11 promoter."
30202049
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"BAP1, in collaboration with p53, reduced the level of expression of SLC7A11."
39846440
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"Importantly, restoration of BAP1 WT, but not its C91A mutant, in BAP1 CRISPR knockout (KO) (sgBAP1) 786-O cells decreased SLC7A11 expression to a level similar to that in 786-O control cells (XREF_FIG)."
30202049
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"For example, Zhang and colleagues found that tumor suppressor BRCA1 associated protein 1 (BAP1) reduced the occupancy of H2Aub on the SLC7A11 promoter and inhibited the expression of SLC7A11 in a deubiquitination-dependent manner [43]."
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"These authors further demonstrated that BAP1 inhibited cystine uptake by inhibiting the expression of SLC7A11, thus resulting in increased lipid peroxidation and ferroptosis."
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"However, restoring BAP1 in p53 deficient cells still inhibited SLC7A11 expression (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY), and the fold change in SLC7A11 expression by BAP1 restoration in p53 deficient cells was similar to that in p53-proficient cells (XREF_SUPPLEMENTARY), suggesting that BAP1 represses SLC7A11 expression independent of p53."
30202049
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"The mechanism may be that BAP1 represses the transcription of SLC7A11 by reducing histone 2A ubiquitination (H2Aub) on the SLC7A11 gene (49)."
35434035
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"BAP1 was shown to repress SLC7A11 expression in a deubiquitination-dependent manner, thereby promoting ferroptosis (60)."
37703360
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"BAP1 removes H2A ubiquitination on the SLC7A11 promoter and reduces SLC7A11 transcription through its deubiquitinating activity, thereby curbing cystine uptake and promoting ferroptosis."
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"In addition, erastin potently induced SLC7A11 expression in BAP1 deficient cells (XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY), suggesting that BAP1 represses the basal expression of SLC7A11 and that erastin induces SLC7A11 expression likely through BAP1 independent mechanisms."
30202049
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"In fact, several studies demonstrate that BAP1 reduces the expression of SLC7A11, with a consequent increase in lipid peroxidation and therefore ferroptosis induction [164,165,166]."
38539554
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"Specifically, our study suggests a model in which the tumor suppressor BAP1 normally functions to repress the expression of SLC7A11 at least partly by deubiquitinating H2Aub on SLC7A11, thereby inhibiting cystine uptake into cells and rendering them more sensitive to ferroptosis."
30202049
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"Tumor suppressor genes TP53, BECN1, BAP1 downregulate the expression of SLC7A11 to induce ferroptosis (Jiang et al., 2015; Song et al., 2018; Zhang et al., 2018)."
36968201
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"At the SLC7A11 promoter, BAP1 deubiquitinates H2Aub and subsequently inhibits the expression of SLC7A11."
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"Conversely, BAP1 deletion by CRISPR technology in 786-O cells (a BAP1-proficient cancer cell line) increased SLC7A11 expression but did not affect GPX4 level."
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"BAP1 inhibits SLC7A11 expression in a deubiquitination-dependent manner, leading to increased ROS levels and ferroptosis [29]."
37604811
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"Additionally, transcription factors such as p53 and BRCA1-associated protein 1 have been shown to inhibit SLC7A11 expression at the transcriptional level, promoting ferroptosis in cancer cells [48]."
40012016
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"Our study suggested that BAP1 represses SLC7A11 expression through BAP1 mediated H2Aub deubiquitination on SLC7A11."
30202049
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"Hypoxia-induced BAP1 decreased SLC7A11 expression by stabilizing H2A."
39245739
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"BAP1 is known to inhibit SLC7A11 expression."
39266549
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"In addition, the tumor suppressor BAP1 decreases H2Aub occupancy on the SLC7A11 promoter and represses SLC7A11 expression in a deubiquitinating-dependent manner, that is, BAP1 inhibits cystine uptake by repressing SLC7A11 expression, leading to elevated lipid peroxidation and ferroptosis rates [54]."
37580393
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"We recently discovered that tumor suppressor BAP1, a H2A deubiquitinase, represses SLC7A11 expression by reducing H2A ubiquitination (H2Aub) on the SLC7A11 promoter."
30907299
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"In addition to TFs, SLC7A11 transcription is also repressed by BRCA1-associated protein 1 (BAP1) – a major component of a deubiquitinase (DUB) complex which catalyzes deubiquitination of histone 2 A (H2A) associated with the SLC7A11 promoter.96 Not surprisingly, BAP1 promotes ferroptosis in a DUB-dependent manner."
35224150
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"BAP1 decreases H2Aub occupancy on the SLC7A11 promoter and inhibits SLC7A11 expression in a deubiquitinating-dependent manner [ 41 ]."
37422058
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"BRCA1-associated protein 1 (BAP1) [18], the crucial constituent of the deubiquitinase complex, attenuated the initiation and extension of SLC7A11 transcription by deubiquitinating histone 2A, while the steady-state levels and half-life of SLC7A11 were improved by combination with the ovarian tumor family member deubiquitinase (OTUB1) [19]."
32908642
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"In addition, overexpression of BAP1 reversed the effects of Exos , decreased the expression levels of SLC7A11 and GPX4, and increased the ACSL4, which was analyzed by RT-qPCR and western blot (Figures 6F and 6G)."
39391723
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"Specially, previous studies demonstrate that BAP1 downregulates SLC7A11 expression by reducing histone 2A ubiquitination occupancy on its promoter (Zhang et al., 2018b)."
37250891
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"Similarly, BAP1, an epigenetic regulator and tumor suppressor mutated in various types of cancer, can downregulate the transcription of SLC7A11 and thus potentiate ferroptosis (Zhang et al., 2018)."
32294465
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"p53 binds to the SLC7A11 promoter, directly suppressing its transcription; the nuclear deubiquitinase (DUB) BAP1 represses SLC7A11 transcription by removing histone 2A ubiquitination from the SLC7A11 promoter; and KEAP1 represses SLC7A11 transcription through degrading NRF2, a master transcription factor of antioxidant response and regulator of SLC7A11."
30987975
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"As a deubiquitinating enzyme, BAP1 inhibits the expression of SLC7A11 by reducing the ubiquitination of H2A to inhibit the activity of SLC7A11 promoter (23)."
32944533
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"Similarly, another group reported that tumor suppressor BRCA1-associated protein 1 (BAP1) protein repressed the expression of SLC7A11 in a deubiquitinating-dependent manner, resulting in accumulation of lipid peroxidation and ferroptosis."
36851083
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"Mechanistically, BAP1 reduces H2A-ubiquitin occupancy of the SLC7A11 promoter and then represses SLC7A11 expression, which finally results in GSH depletion and lipid peroxidation [ 100 ]."
30880243
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"BAP1, a nuclear deubiquitase, represses SLC7A11 expression by reducing H2A ubiquitination on the SLC7A11 promoter, thereby regulating ferroptosis [77]."
35804831
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"Two key tumor suppressor proteins, p53 (TP53) (Jiang et al., 2015) and BAP1 (Zhang et al., 2018a), independently suppress SLC7A11 expression."
32302583
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"Finally, while BAP1 and PRC1 exert opposing effects on H2Aub binding on the SLC7A11 promoter, both BAP1 and PRC1 repress SLC7A11 expression."
30907299
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"This is consistent with our finding that BAP1 represses SLC7A11 expression (therefore, lower dosages of erastin were needed to block SLC7A11 activity and to induce ferroptosis in BAP1 expressing cells, which exhibited lower expression of SLC7A11)."
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"Recent studies have demonstrated that BAP1 can inhibit the expression of the cystine transporter SLC7A11, reduce the uptake of cystine, cause the decrease of intracellular GSH and GPX4 levels, and the increase of lipid peroxidation, and ultimately disrupting cell membranes and inducing ferroptosis in tumor cells [13]."
40080966
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"By removing ubiquitin from H2Aub on the SLC7A11, BAP1 can repress SLC7A11 expression [89]."
32103754
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"Western blot data showed that overexpression of BAP1 could reduce the expression of SLC7A11, while the knock down of BAP1 increased the expression (Figure 5D)."
39391723
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"BAP1 reverses the suppressing effects of Exos on H/R-induced cardiomyocytes’ ferroptosis by downregulating the expression of SLC7A11, decreasing the GSH/GSSH ratio."
39391723
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"BAP1 deubiquitinates histone 2A (H2Aub) on the SLC7A11 promoter and represses SLC7A11 expression in a p53-independent way (39, 40)."
39290692
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"Similar to BAP1, PRC1 inhibits the expression of SLC7A11, even though PRC1 and BAP1 have opposite effects on the levels of H2Aub on the SLC7A11 promoter."
39290692
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"Furthermore, BAP1 was found to inhibit the expression of SLC7A11 by reducing the H2Aub level on the promoter of SLC7A11."
40080966
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"Our results revealed that transfection with H2Aub K119R mutant plasmid reduced the transcription and protein expression of SLC7A11 and GPX4, and overexpression of BAP1 can promote neuronal ferroptosis by regulating H2Aub levels."
40080966
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"Moreover, the tumor suppressor gene, BRCA1-associated protein 1 (BAP1), was found to reduce SLC7A11 expression by decreasing histone 2A ubiquitination occupancy on its promoter in human cancer, which consequently resulted in increased ferroptosis (Zhang et al., 2018)."
35531466
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"Furthermore, FOXO3a inhibition also inhibited the mRNA and protein expression levels of BAP1, while simultaneously increasing the levels of SLC7A11 and GPX4 after SAH in mice (Fig. 8C–F)."
40080966
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"Epigenetically, BAP1 inhibits SLC7A11 expression through de-ubiquitinating H2A [13], while chromatin remodeling factor ARID1A increases SLC7A11 expression [14]."
34385181
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"The H2A ubiquitin ligases BAP1 and protein regulator of cytokinesis 1 inhibit expression of SLC7A11."
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