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"The Chk signal transducers induce cell cycle arrest by phosphorylation of two critical effectors : inhibitory phosphorylation of the Cdc25 phosphatase results in CDK inactivation, while the activating phosphorylation of the p53 tumor suppressor stabilizes p53 and increases transcription of p53 target genes, including the cyclin dependent kinase inhibitor p21/CIP1/WAF-1."
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"We show that the C-terminal sequence of PEPD binds to the PRD in p53, which allows PEPD to accomplish two important tasks : (1) to prevent nuclear p53 phosphorylation in its transactivation domain andto reduce free nuclear p53 level, leading to inhibition of p53 trans-activation and trans-suppression activities, and (2) to prevent mitochondrial translocation of nuclear and cytosolic p53 by preventing p53 from binding to MDM2 (Figs."