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Phosphorylated TP53 decreases the amount of TP53. 4 / 4
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"The Chk signal transducers induce cell cycle arrest by phosphorylation of two critical effectors : inhibitory phosphorylation of the Cdc25 phosphatase results in CDK inactivation, while the activating phosphorylation of the p53 tumor suppressor stabilizes p53 and increases transcription of p53 target genes, including the cyclin dependent kinase inhibitor p21/CIP1/WAF-1."
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"Moreover, CB1 antagonism with AM281 resulted in higher nuclear translocation of phosphorylated p53, whereas the CB1 agonist ACEA lowered the levels of nuclear p53 compared to vehicle (Figure 4F and G).3.5 Lack of myeloid CB1 promotes a less pro-inflammatory macrophage phenotype."
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"Specifically, metformin treatment increased the ratio of phosphorylated to total p53 protein while reducing total p53 protein expression."
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"We show that the C-terminal sequence of PEPD binds to the PRD in p53, which allows PEPD to accomplish two important tasks : (1) to prevent nuclear p53 phosphorylation in its transactivation domain andto reduce free nuclear p53 level, leading to inhibition of p53 trans-activation and trans-suppression activities, and (2) to prevent mitochondrial translocation of nuclear and cytosolic p53 by preventing p53 from binding to MDM2 (Figs."
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