IndraLab

Statements

HIPK2 activates JNK. 16 / 19
| 15 1
reach
"However, SUMO-1 modification inhibited HIPK2 induced JNK activation and p53 independent antiproliferative function."
15958389
reach
"In addition, HIPK2 also activates the apoptotic response independent of p53 by regulating the JNK pathway and by targeting the anti-apoptotic transcriptional repressor CtBP for degradation."
24982848
reach
"RNA interference mediated HIPK2 knockdown inhibits TGF- beta -induced JNK activation [XREF_BIBR], and HIPK2 effect on JNK is modulated through dynamic SUMO-1 modification [XREF_BIBR]."
28107201
reach
"Hofmann et al. [XREF_BIBR] have demonstrated that SUMO protease SuPr-1 interacts with HIPK2 and deconjugates SUMO from HIPK2, thereby antagonizing the inhibitory effect of SUMO-1 on HIPK2 mediated JNK activation."
27689990
reach
"19 However, the role of HIPK2 activation in JNK activation upon glucose restriction needs to be further elucidated because several signaling kinases may regulate survival during glu stv."
23703384
reach
"Previous reports showed that HIPK2 can signal cell death via p53, and independently of p53 by activating the c-Jun NH2-terminal kinase (JNK) pathway or mediating CtBP degradation."
15958389
reach
"Interestingly, loss of HIPK2 selectively blocks JNK activation without affecting Xbp1 splicing or the activation of IRE1alpha and ASK1 (XREF_FIG)."
27321923
reach
"HIPK2 with a mutated SUMO acceptor lysine residue was refractory to inhibition of HIPK2 mediated JNK activation by SUMO-1."
15958389
reach
"To investigate whether HIPK2 activation might contribute to the pathogenesis of ALS caused by SOD1 mutations, we asked if loss of HIPK2 could block JNK activation in SOD1 G93A mice."
27321923
reach
"Subsequently, homeodomain-interacting protein kinase 2 (HIPK2), involved in transcriptional regulation and apoptosis, was shown to activate JNK via DAXX and the mitogen-activated protein kinase kinases MKK4 (MAP2K4) and MKK7 (MAP2K7)."
31350900
reach
"Moreover, overexpression of HIPK2 leads to Daxx phosphorylation, and ectopic expression of HIPK2 activates the JNK signaling pathway, which is enhanced by coexpression of Daxx."
14678985
reach
"SuPr-1 deconjugates SUMO-1 from HIPK2 in vitro and in vivo, which results in modestly increased HIPK2 induced JNK activity."
15958389
reach
"HIPK2 promotes JNK activation and neuronal cell death in SOD1 G93A mice."
27321923
reach
"Finally, we demonstrate that knockdown of endogenous HIPK2 using RNA interference inhibits TGF-beta-induced JNK activation and apoptosis."
14678985
reach
"In addition, over-expression of HIPK2-S359A and HIPK2-T360A, but not HIPK2-Y361F, blocked JNK activation in response to tunicamycin treatment (XREF_FIG), suggesting that HIPK2 phosphorylation at S359 and T360 is required to promote ER stress induced JNK activation."
27321923
sparser
"However, SUMO-1 modification inhibited HIPK2-induced JNK activation and p53-independent antiproliferative function."
15958389