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USP10 deubiquitinates TRAF6. 5 / 6
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"The USP10-dependent deubiquitination of NEMO and TRAF6 proteins is another strategy through which MCPIP1 can regulate inflammation and the immune response [34]."
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"USP10 also deubiquitinates TRAF6 after formation of the complex with TRAF family member-associated NF-κB activator and monocyte chemotactic protein-1-induced protein 1, which negatively regulates genotoxic stress or IL-1β-mediated NF-κB activation (34)."
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"We found TANK formed a complex with MCPIP1 (also known as ZC3H12A) and a deubiquitinase, USP10, which was essential for the USP10 dependent deubiquitination of TRAF6 and the resolution of genotoxic NF-kappaB activation upon DNA damage."
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"TRAF Family Member associated NF-kappaB Activator (TANK) Inhibits Genotoxic Nuclear Factor kappaB Activation by Facilitating Deubiquitinase USP10 dependent Deubiquitination of TRAF6 Ligase."
25861989
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"USP10 targets and deubiquitinates TRAF6 and NEMO to inhibit NF-κB and type I IFNs ( Wang et al., 2015b ; Niu et al., 2013 )."
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