IndraLab
Statements
sparser
"The results of both groups support a model in which the BRAF-specific inhibitors induce RAS-GTP-dependent RAF1 activation via the formation of BRAF-RAF heterodimers or RAF1 homodimers followed by recruitment of RAF1 to the plasma membrane, triggering the MEK-ERK pathway ( xref ; xref )."
sparser
"Analysis of the mechanisms of cutaneous toxicities (notably, cuSCC) suggest that in BRAF wt cells, BRAF inhibitors cause formation of RAF dimers that lead to signaling through CRAF, particularly in those with an upstream mutation such as RAS . xref – xref Studies have shown frequent mutations in HRAS , and to a lesser extent NRAS , in benign and malignant (cuSCCs) proliferative lesions resected from patients on BRAF inhibitors, at higher rates than in lesions from patients not treated with inhibitors. xref – xref "
sparser
"Packer et al. [42] reported that the binding of weak RAF inhibitors (imatinib, nilotinib and dasatinib) to BRAF and CRAF drives BRAF:CRAF heterodimer as well as BRCF and CRAF homodimer formation in the presence of oncogenetic RAS, thus leading to paradoxical activation of both BRAF and CRAF, followed by the activation of MEK and ERK."