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CXXC1 methylates TP53. 14 / 14
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"The incidence was 6.5% of p53 gene promoter CpG island methylation in 46 cases of laryngeal cancer, while methylation rate was 4.3% in adjacent tissues,no significant difference of p53 gene methylation was found in laryngeal cancer and counterparts adjacent tissues( P >0.05)."
29871161
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"We conclude that uteroplacental insufficiency alters p53 DNA CpG methylation, affects mRNA levels of key apoptosis-related proteins, increases renal apoptosis, and reduces glomeruli number in the IUGR kidney."
12869365
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"Uteroplacental insufficiency specifically decreased CpG methylation of the renal p53 BstU I site promoter without affecting the Hha I or the Aci I sites."
12869365
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"By contrast, the mean of p53 or RASSF1A promoter CpG sites methylation decreased in post-exposure DNA samples."
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"Before and after GT, we analyzed the levels of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts (BPDE-DNA), p53 protein in serum, 5-methylcytosine (5-mC, global DNA methylation), and methylation in selected CpG sites of p53 gene."
32726118
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"The Ms-SNuPE assay provides a quantitative measure of the percent methylation at specific CpG sites in the promoter region of p53 gene."
11804744
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"As several TP53 CpG methylation sites are mutational hotspots in cancer (), an oligodeoxynucleotide corresponding to part of exon 8 was synthesized with 5MeC incorporated at two known sites of methylation in codons 273 and 282 ( xref )."
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"In the present study, we have determined the TP53 CpG methylation profile in the substituted segment of Hupki embryonic fibroblasts and compared it to the methylation profile of the same segment when present in normal human neonatal fibroblasts, using two independent assays, including the combined bisulfite-restriction analysis (COBRA) [ xref ], and sodium bisulfite genomic sequencing [ xref ]."
20945503
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"These data confirm that site‐specific changes of intragenic TP53 CpG methylation are extrinsically inducible, and suggest that human cancer progression is mediated in part by dysregulation of damage‐inducible intragenic CpG demethylation that alters TP53 P1/P2 isoform expression. © 2015 The Authors."
26676339
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"Pogribny et al. / Cancer Letters 115 (1997) 31-38 independent methylation of CpG sites in the p53 gene: impli- [33] Wu, J.J., Herman, J.G., Wilson, G., Lee, R.Y., Yen, R.W.C., cations for mutation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9097976
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"All of the CpG sites in Hupki TP53 are methylated xref ."
25847421
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"Because altered p53 CpG methylation affects p53 expression, we analyzed p53 promoter CpG methylation using methylation-sensitive restriction enzymes and real-time PCR."
12869365
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"DNA methylation of TP53 and p16 at CpG sites was quantified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) of the MassArray system (Sequenom EpiTYPER [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To clarify this, we first assessed site‐specific TP53 CpG methylation in normal and transformed cells."
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