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NFkappaB activates CYLD. 19 / 20
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"9 These data suggest that CYLD controls inflammation through TRAF signaling and NF-kappaB p65 and p50 activation or cellular proliferation through Bcl-3 activation and NF-kappaB p50 and p52 binding.Re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, activated NF-kappaB stimulates transcriptional upregulation of CYLD to antagonize TRAF6 by promoting its K63 linked deubiquitination, presenting a negative feedback loop of NF-kappaB activation [XREF_BIBR]."
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"Of the 128 screened siRNA pools, 15 matched these criteria including those targeting the known negative regulators of NF-kappaB signalling CYLD and A20."
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"NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB : evidence for a novel inducible autoregulatory feedback pathway."
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"This results in inhibition of NF-κB activation and loss of CYLD is shown to inhibit apoptosis (Trompouki et al., xref ; Figure xref )."
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"In contrast, when the NF-kappaB pathway is overactive, as in mice expressing the constitutively activated IkappaB kinase in hematopoietic cells or mice deficient in the negative regulator of NF-kappaB signalling CYLD, NKT cellsdevelop but these cells fail to mature and to populate the periphery 61."
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"Either pharmacological deactivation of NF-kappaB or genetic upregulation of CYLD compromises the apoptosis resistant phenotypes of miR-19a."
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"However, subsequent studies have indicated that although CYLD targets NF-kappaB signaling factors, its function may depend on the cell type and stimulating receptor [XREF_BIBR]."
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"Moreover, as CYLD can be transcriptionally induced by the NF-kappaB pathway in a negative feedback pathway [XREF_BIBR], we may have uncovered a mechanism that leads to persistent NF-kappaB activation in gastric cancer."
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"The NF-kappaB activation in CYLD deficient thymocytes is independent of CARMA1, because the NF-kappaB activation was also detected in CYLD and CARMA1 double knock-out thymocytes."
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"As such, RIPK1 deubiquitination is mediated by a range of multiple deubiquitinating enzymes (DUBs) such as A20 and cylindromatosis (CYLD), which are upregulated by NF-kappaB at excessive intracellular concentrations of TNF-alpha [XREF_BIBR, XREF_BIBR]."
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"On the other hand, mice that express overactive NF-kappaB or lack the negative regulator of NF-kappaB signaling CYLD, develop NKT cells but fail to mature and populate the lymphoid organs and peripheral tissues."
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"Supporting evidence for NF-kappaB- dependent upregulation of CYLD was provided by genomic sequence analysis that revealed NF-kappaB binding sites within the CYLD promoter region [37]."
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"These data suggest that activation of Notch signaling in myeloid cells aggravates I/R injury, by enhancing the inflammation response by NF-kappaB through down regulation of CYLD."
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"The suppression of CYLD protein levels during hypoxia induced NF-kappaB activation is particularly noteworthy, because NF-kappaB has been shown to transcriptionally activate the CYLD gene."
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"The present study revealed a novel autoregulatory feedback pathway through which activation of NF-kappaB by TNF-alpha and bacterium nontypeable Haemophilus influenzae (NTHi) induces CYLD that in turn leads to the negative regulation of NF-kappaB signaling."
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"Deubiquitinases A20 and Cezanne, but not CYLD, are induced by NF-kappaB to negatively regulate TAK1 and NF-kappaB activity by removing K63 polyubiquitin chains [XREF_BIBR]."
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"The increase of NF-kappaB activation in CYLD knockdown cells was attributed to defective removal of K63 Ub chains from TRAF2 and NF-kappaB essential modulator (NEMO) by CYLD."
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"Either pharmacological deactivation of NF-kappaB or genetic upregulation of CYLD within miR-19a-replete cells largely abolishes the apoptosis resistant phenotypes of miR-19a."
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