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EGFR phosphorylates SRC. 62 / 70
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"EGFR (Tyr845) is a known Src kinase substrate which is not phosphorylated by the EGFR kinase XREF_BIBR."
20101245
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"In addition, C-ANP 4-23 treatment also attenuated the enhanced expression of AT1 receptor, Gqalpha, PLCbeta1, Nox4, and p47 phox proteins, the enhanced activation of EGFR, PDGFR, IGF-1R, enhanced phosphorylation of ERK1/2/AKT and c-Src in VSMC from SHR."
29417757
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"Previous reports about the involvement of AnxA2 in transportation of Src to the membrane led us to investigate whether AnxA2 downregulation interferes with EGF induced phosphorylation of Src by EGFR."
22957061
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"These ligands activated EGFR, as well as ABL1, EPHA6, and SRC that were phosphorylated and activated by EGFR."
31694343
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"VAV1 was activated by Src dependent phosphorylation, which in turn was activated by EGFR, and led to activation of a Rac-Pak-NF-kappaB signalling pathway and cyclin D1 upregulation."
21102635
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"In contrast, blockade of the EGFR by AG1478 inhibited phosphorylation of ERK1/2 but not Src or Akt phosphorylation following H (2) O (2) exposure."
15075181
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"21,26 On the other hand, the epidermal growth factor receptor phosphorylates and activates Src, which, in turn, phosphorylates Tks5."
19464300
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"Activation of EGFR and downstream phosphorylation of Src, ERK and AKT has also been reported in rat mesangial cells upon Cd treatment."
26385184
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"CCN2 inhibits EGFR mediated phosphorylation of c-Src and extracellular signal regulated kinase (ERK)."
23175185
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"However, EGFR siRNA had no effect on LPS induced Src phosphorylation."
29207668
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"EGFR can phosphorylate MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin [37] , and hundred folds up-regulation of MUC1 pY1238 was also observed.Protein kinase B, also known as AKT, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27916117
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"Compared with mock cells, TM4SF5 WT or TM4SF5 ΔC cells showed higher pY 416 c-Src and pY 845 EGFR, pY 992 EGFR, and pY 1173 EGFR; TM4SF5 WT cells showed increases in pY 416 c-Src, pY 845 EGFR, and pY [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23220047
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"These studies for the first time demonstrate that LPS induced Src phosphorylation to activate EGFR, activation EGFR mediated phosphorylation of ERK and STAT3, which increase expression of COX2 and eNOS, and production of cytokine to mediate kidney injury respectively."
29207668
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"Another point of interest is the fact that the two partners in the well-known bidirectional activatory trans-phosphorylation between EGFR and Src, where Src phosphorylates the EGFR [ xref – xref ], and the EGFR phosphorylates Src [ xref ], are regulated by CaM, albeit in different manners."
26058065
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"They inhibit the phosphorylation of the peptide substrate RR-Src by the EGF receptor purified from ER 22 cells, with IC50 values in the range 0.02-0.45 microns."
8639248
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"Mechanistically, as an epidermal growth factor receptor (EGFR)‐binding protein, KIAA1199 promotes EGFR signaling and regulates EGFR‐dependent Src, Erk, and Akt phosphorylation, as well as downstream kinases in the EGF‐mediated EMT pathway."
32519472
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"Studies by Li et al. [9,15,17] identified a Tyr 46 –Glu–Lys–Val tetrapeptide motif in the MUC1 CT that was phosphorylated by the epidermal growth factor (EGF) receptor (ErbB1), c-Src, and Lyn kinases."
15358196
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"In addition, dexmedetomidine-induced EGFR phosphorylation (Tyr1068) was inhibited by the alpha-2 adrenoceptor inhibitor rauwolscine at a 10 M concentration and also using the Src kinase inhibitors, PP1 at 10 M and PP2 at 10 M (Figure 3B; p < 0.001 versus dexmedetomidine alone)."
35457136
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"The cannabinoid induced activation of the EGFR leads to the subsequent phosphorylation and activation of the adaptor protein Src homology 2 domain containing (shc), and downstream activation of the ERK1/2 and Akt and PKB pathways."
19647123
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"The inhibitory effect of Zn 2+ treatment on Src activity was also pronounced in the absence of pyrithione These results confirmed that Zn 2+ -induced EGFR phosphorylation is independent of Src kinase [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16410015
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"In addition, TNF-α is also received by the EGF receptor (EGFR), which triggers the phosphorylation of downstream protein SRC and enters the P13K/AKT signaling pathway."
37373186
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"For the first time, we demonstrated that stimulation of the GAGA A R leads to EGFR signaling activation, including elevated expression of EGFR ligands, trans -phosphorytion of the EGFR, and tyrosyl ph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24296312
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"In addition, TNF-α is also received by the EGF receptor (EGFR), which triggers the phosphorylation of downstream protein SRC and enters the P13K/AKT signaling pathway."
37373186
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"For example, the EGF receptor kinase phosphorylates src peptides (Pike et al., PNAS 79, 1443-1447, 1982) and antibodies to the src kinase (Chinkers and Cohen, Nature 290, 516-519, 1981; Kudlow et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
6327062
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"NT also induced a time-dependent increase in EGFR Tyr(845) phosphorylation and phosphorylation of c-Src and signal transducer and activator of transcription 5b (Stat5b) (a downstream effector of Tyr(845)), events that were blocked by specific inhibition of c-Src (which mediates Tyr(845) phosphorylation of EGFR) or of EGFR."
16862179
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"Both Src and Flyn (both members of SFK) associate with and are phosphorylated by EGFR in glioma cells."
28629170
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"Another point of interest is the fact that the two partners in the well-known bidirectional activatory trans-phosphorylation between EGFR and Src, where Src phosphorylates the EGFR [XREF_BIBR - XREF_BIBR], and the EGFR phosphorylates Src [XREF_BIBR], are regulated by CaM, albeit in different manners."
26058065
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"Moreover, IL-1b had been shown to induce phosphorylation of Src which was also inhibited by PP1, not by inhibitors of MMP (GM6001), EGFR (AG1478), and PDGFR (AG1296)."
17299794
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"On the other hand, EGFR phosphorylation at tyrosine 845, a SRC kinase phosphorylation site22was increased, consistent with PTP1B-mediated SRC activation23."
31873221
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"To investigate the mechanism of STAT3 phosphorylation inhibition, we analyzed the phosphorylation of STAT3, JAK family proteins, Src, and epidermal growth factor receptor (EGFR) at various times after[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24607275
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"Pretreatment of VSMC with the specific src family kinase inhibitor SU6656 effectively blocked TGF-β1-initiated increases in both pp60 c- src and EGFR phosphorylation (as detected with the phospho-tyro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18255094
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"21,26 On the other hand, the epidermal growth factor receptor phosphorylates and activates Src, which, in turn, phosphorylates Tks5."
19464300
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"In the EGF receptor system it associates with this receptor through interaction with the adaptor Shc and with the tyrosine kinase Src and it increases Src activity when it is phosphorylated by Src and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20851120
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"Src can also be directly phosphorylated by EGFR [XREF_BIBR], and as FAK is recruited to sites of integrin clustering and is required for growth factor stimulated motility, Src is likely involved in the cooperativity or crosstalk between growth factor and integrin signaling [XREF_BIBR]."
22926411
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"In addition, inhibition of EGFR blocked BI-induced Src, Jak2, and STAT3 phosphorylation."
21536676
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"Thus, activation of the gintonin-biotin conjugate-mediated LPA receptor transactivates the EGF receptor via c-Src phosphorylation and activated EGF receptor is also coupled to ERK activation, resulting in cell migration that is blocked by the EGF receptor inhibitor (Fig. 6).4 Discussion."
35600777
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"Hence, the excessive activation of EGFR promotes the phosphorylation of c-Src and then activates NF-κB pathway, which is perhaps one of the important mechanisms of RIF in diabetes.Fraxin is the main p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37467841
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"For the first time, we demonstrated that stimulation of the GAGA A R leads to EGFR signaling activation, including elevated expression of EGFR ligands, trans -phosphorytion of the EGFR, and tyrosyl p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24296312
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"For instance, the recruitment of c-Src to EGFR and EGFR-induced phosphorylation of c-Src could be inhibited by NDRG1, the potent metastasis suppressor N-myc downstream regulated gene-1."
27078847
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"Based on the current literature, the likely candidates are : (a) EGFR, that is known to phosphorylate PLD2 [21]; or (b) Src family of kinases Fyn and Fgr, as recently demonstrated [24], regarding PLD2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15896299
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"Consistently, the molecular analyses of the PP121- or SC-1–treated tumors revealed a reduction in the phosphorylation of multiple growth factors signaling proteins, including the phosphorylation of Src family kinases, EGFR, and FAK compared with vehicle-treated controls (SI Appendix, Fig. S5B)."
34593636
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"Lee et al. [39] reported that 1,8-cineole inhibited phosphorylation of ERK1/2, its upstream kinases, c-Src and epidermal growth factor receptor (EGFR)."
30508640
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"Previous reports about the involvement of AnxA2 in transportation of Src to the membrane led us to investigate whether AnxA2 downregulation interferes with EGF-induced phosphorylation of Src by EGFR."
22957061
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"While, EGFR can phosphorylate Src at Y416 position, oncogenic Src (v-Src) can lead to phosphorylation of EGFR at Y845 site xref ."
22957061
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"The association of Rap1 in the modulation of EGFR level, its signaling pathway and pathological condition such as PE and FGR would be considered in our subsequent study.In conclusion, Rap1 functions as a mediator of EGF/HB‐EGF‐induced AKT, ERK1/2, p38MAPK, and Src phosphorylation via the EGFR signaling pathway and is a posttranscriptional modulator of EGFR during EVT invasion."
37614815
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"Transactivation of the EGF receptor elicits phosphorylation of its Src homology 2 domain-containing (Shc) adaptor, with consequent downstream activation of mitogenic protein kinase pathways.Similar re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17222464
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"Either EGF treatment ( Figure 2 J) or EGF receptor (EGFR) overexpression ( Figure 2 K) remarkably stimulated the phosphorylation of both c-Src and PFKFB3-Y194, which was significantly diminished by PP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32209481
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"Finally, phosphorylated Dock180(Y722) is coexpressed with EGFRvIII and phosphorylated Src(Y418) in clinical specimens, and such coexpression correlates with an extremely poor survival in glioblastoma patients."
22323579
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"Unlike EGF-activated EGFR, CS-stimulated EGFR triggers aberrant Src phosphorylation in lung cancer cells ( xref )."
29286114
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"Mechanistically, de4 EGFR significantly upregulated the extracellular regulated protein kinase, AKT, focal adhesion kinase (FAK) and Src phosphorylation and matrix metalloproteinase-9 expression while downregulated the expression of E-cadherin."
23764753
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"Abolition of SRC kinases-mediated EGFR phosphorylation has been shown to inhibit EGF-induced proliferation and/or transformation in many types of cancer cells, such as breast cancer cells and cervical cancer cells [ xref , xref ]."
26849234
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"It should be noted that Src can induce activation of EGFR by direct phosphorylation on Tyr-845. xref An experimental study with a mutation of EGFR at Tyr845 found that Tyr845 is essential for EGF-induced DNA synthesis in murine fibroblasts. xref This experiment also demonstrated that Src dependent EGFR phosphorylation (Tyr845) is required for DNA synthesis induced by G protein-coupled agonists (endothelin and LPA), cytokines, and growth hormone in murine fibroblasts. xref In addition, over-expression studies in tumor cell lines revealed that c-Src-induced tyrosine phosphorylation of EGFR at 845 is required for the mitogenic and malignant properties of EGFR. xref These findings indicate that Src-dependent phosphorylation at Tyr845 is essential for EGFR to exert its cellular functions."
26444028
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"In the present study, we showed that the c-Src inhibitor PP2 significantly blocked Ang II induced EGFR phosphorylation, while EGFR shRNA had no effect on Ang II induced c-Src phosphorylation."
26762600
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"Src phosphorylation by EGFR especially is considered to stimulate the onset of hyper-proliferation of tumour cells and induction of vascular permeability and neovascularisation [ xref , xref ]."
21461590
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"Unlike EGF activated EGFR, CS stimulated EGFR triggers aberrant Src phosphorylation in lung cancer cells."
29286114
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"3.5 P2R antagonists do not transactivate the EGFR to increase ERK1/2 and Src phosphorylation."
21397667
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"As shown in XREF_FIG, the activation of Src (shown as pTyr419Src) by 539741 was abrogated in the presence of AG1478, revealing that PTP1B negatively regulates Src through EGFR dephosphorylation that eliminates the ability of EGFR to phosphorylate Src."
26453921
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"Src can also be directly phosphorylated by EGFR [ xref ], and as FAK is recruited to sites of integrin clustering and is required for growth factor-stimulated motility, Src is likely involved in the cooperativity or crosstalk between growth factor and integrin signaling [ xref ]."
22926411
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"Diabetes augmented and treatment with PP2 inhibited the phosphorylation of Src Tyr 416, EGFR Tyr 1173, and p38 and ERK1/2 (XREF_FIG)."
23942551
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"An Src inhibitor (dasatinib) completely suppressed EGFR, Akt, and ERK phosphorylation induced by high D-dimer plasma ( xref ) and also significantly inhibited platelets of the high D-dimer plasma adherence to HCC827 cells ( xref )."
35756605
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"Src phosphorylation by EGFR especially is considered to stimulate the onset of hyper-proliferation of tumour cells and induction of vascular permeability and neovascularisation [XREF_BIBR, XREF_BIBR]."
21461590
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"On the other hand, a detrimental effect is observed when EGFR becomes phosphorylated in a Src-dependent manner in VSMCs grown in high glucose."
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