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EGFR phosphorylates SRC. 49 / 49
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"In addition, C-ANP 4-23 treatment also attenuated the enhanced expression of AT1 receptor, Gqalpha, PLCbeta1, Nox4, and p47 phox proteins, the enhanced activation of EGFR, PDGFR, IGF-1R, enhanced phosphorylation of ERK1/2/AKT and c-Src in VSMC from SHR."
29417757
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"They inhibit the phosphorylation of the peptide substrate RR-Src by the EGF receptor purified from ER 22 cells, with IC50 values in the range 0.02-0.45 microns."
8639248
rlimsp
"Starting with 5-S-glutathionyl-beta-alanyl-L-dopa (1) and 5-S-glutathionyl-beta-alanyl-dopamine (2), a series of analogues with truncated glutathionyl and beta-alanyl-dopa moieties were synthesized, and their inhibitory effects on autophosphorylation and substrate phosphorylation reaction by c-Src and by epidermal growth factor receptor (EGFR) were evaluated."
9987835
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"It should be noted that Src can induce activation of EGFR by direct phosphorylation on Tyr-845. xref An experimental study with a mutation of EGFR at Tyr845 found that Tyr845 is essential for EGF-induced DNA synthesis in murine fibroblasts. xref This experiment also demonstrated that Src dependent EGFR phosphorylation (Tyr845) is required for DNA synthesis induced by G protein-coupled agonists (endothelin and LPA), cytokines, and growth hormone in murine fibroblasts. xref In addition, over-expression studies in tumor cell lines revealed that c-Src-induced tyrosine phosphorylation of EGFR at 845 is required for the mitogenic and malignant properties of EGFR. xref These findings indicate that Src-dependent phosphorylation at Tyr845 is essential for EGFR to exert its cellular functions."
26444028
rlimsp
"Another point of interest is the fact that the two partners in the well-known bidirectional activatory trans-phosphorylation between EGFR and Src, where Src phosphorylates the EGFR [35–39], and the EGFR phosphorylates Src [30], are regulated by CaM, albeit in different manners."
26058065
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"Src phosphorylation by EGFR especially is considered to stimulate the onset of hyper-proliferation of tumour cells and induction of vascular permeability and neovascularisation [XREF_BIBR, XREF_BIBR]."
21461590
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"Src can also be directly phosphorylated by EGFR [XREF_BIBR], and as FAK is recruited to sites of integrin clustering and is required for growth factor stimulated motility, Src is likely involved in the cooperativity or crosstalk between growth factor and integrin signaling [XREF_BIBR]."
22926411
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"Both Src and Flyn (both members of SFK) associate with and are phosphorylated by EGFR in glioma cells."
28629170
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"However, EGFR siRNA had no effect on LPS induced Src phosphorylation."
29207668
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"For example, the EGF receptor kinase phosphorylates src peptides (Pike et al., PNAS 79, 1443-1447, 1982) and antibodies to the src kinase (Chinkers and Cohen, Nature 290, 516-519, 1981; Kudlow et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
6327062
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"21,26 On the other hand, the epidermal growth factor receptor phosphorylates and activates Src, which, in turn, phosphorylates Tks5."
19464300
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"Src phosphorylation by EGFR especially is considered to stimulate the onset of hyper-proliferation of tumour cells and induction of vascular permeability and neovascularisation [ xref , xref ]."
21461590
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"Unlike EGF activated EGFR, CS stimulated EGFR triggers aberrant Src phosphorylation in lung cancer cells."
29286114
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"NT also induced a time-dependent increase in EGFR Tyr(845) phosphorylation and phosphorylation of c-Src and signal transducer and activator of transcription 5b (Stat5b) (a downstream effector of Tyr(845)), events that were blocked by specific inhibition of c-Src (which mediates Tyr(845) phosphorylation of EGFR) or of EGFR."
16862179
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"VAV1 was activated by Src dependent phosphorylation, which in turn was activated by EGFR, and led to activation of a Rac-Pak-NF-kappaB signalling pathway and cyclin D1 upregulation."
21102635
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"For the first time, we demonstrated that stimulation of the GAGA A R leads to EGFR signaling activation, including elevated expression of EGFR ligands, trans -phosphorytion of the EGFR, and tyrosyl p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24296312
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"For the first time, we demonstrated that stimulation of the GAGA A R leads to EGFR signaling activation, including elevated expression of EGFR ligands, trans -phosphorytion of the EGFR, and tyrosyl ph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24296312
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"Inclusion of a GABA(A)R antagonist, picrotoxin, or an EGFR tyrosine kinase inhibitor, Gefitinib (ZD1839 or Iressa), blocked isoguvacine and GABA-stimulated cell growth, trans-phospohorylation of EGFR, and tyrosyl phosphorylation of Src in both PCa cell lines."
24296312
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"For instance, the recruitment of c-Src to EGFR and EGFR-induced phosphorylation of c-Src could be inhibited by NDRG1, the potent metastasis suppressor N-myc downstream regulated gene-1."
27078847
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"CCN2 inhibits EGFR mediated phosphorylation of c-Src and extracellular signal regulated kinase (ERK)."
23175185
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"Unlike EGF-activated EGFR, CS-stimulated EGFR triggers aberrant Src phosphorylation in lung cancer cells ( xref )."
29286114
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"As shown in XREF_FIG, the activation of Src (shown as pTyr419Src) by 539741 was abrogated in the presence of AG1478, revealing that PTP1B negatively regulates Src through EGFR dephosphorylation that eliminates the ability of EGFR to phosphorylate Src."
26453921
rlimsp
"Previous reports about the involvement of AnxA2 in transportation of Src to the membrane led us to investigate whether AnxA2 downregulation interferes with EGF-induced phosphorylation of Src by EGFR."
22957061
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"Activation of EGFR and downstream phosphorylation of Src, ERK and AKT has also been reported in rat mesangial cells upon Cd treatment."
26385184
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"Src can also be directly phosphorylated by EGFR [ xref ], and as FAK is recruited to sites of integrin clustering and is required for growth factor-stimulated motility, Src is likely involved in the cooperativity or crosstalk between growth factor and integrin signaling [ xref ]."
22926411
sparser
"Finally, phosphorylated Dock180(Y722) is coexpressed with EGFRvIII and phosphorylated Src(Y418) in clinical specimens, and such coexpression correlates with an extremely poor survival in glioblastoma patients."
22323579
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"Mechanistically, de4 EGFR significantly upregulated the extracellular regulated protein kinase, AKT, focal adhesion kinase (FAK) and Src phosphorylation and matrix metalloproteinase-9 expression while downregulated the expression of E-cadherin."
23764753
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"Previous reports about the involvement of AnxA2 in transportation of Src to the membrane led us to investigate whether AnxA2 downregulation interferes with EGF induced phosphorylation of Src by EGFR."
22957061
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"Another point of interest is the fact that the two partners in the well-known bidirectional activatory trans-phosphorylation between EGFR and Src, where Src phosphorylates the EGFR [ xref – xref ], and the EGFR phosphorylates Src [ xref ], are regulated by CaM, albeit in different manners."
26058065
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"While, EGFR can phosphorylate Src at Y416 position, oncogenic Src (v-Src) can lead to phosphorylation of EGFR at Y845 site xref ."
22957061
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"3.5 P2R antagonists do not transactivate the EGFR to increase ERK1/2 and Src phosphorylation."
21397667
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"In addition, inhibition of EGFR blocked BI-induced Src, Jak2, and STAT3 phosphorylation."
21536676
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"On the other hand, EGFR phosphorylation at tyrosine 845, a SRC kinase phosphorylation site22was increased, consistent with PTP1B-mediated SRC activation23."
31873221
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"EGFR (Tyr845) is a known Src kinase substrate which is not phosphorylated by the EGFR kinase XREF_BIBR."
20101245
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"Based on the current literature, the likely candidates are : (a) EGFR, that is known to phosphorylate PLD2 [21]; or (b) Src family of kinases Fyn and Fgr, as recently demonstrated [24], regarding PLD2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15896299
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"These studies for the first time demonstrate that LPS induced Src phosphorylation to activate EGFR, activation EGFR mediated phosphorylation of ERK and STAT3, which increase expression of COX2 and eNOS, and production of cytokine to mediate kidney injury respectively."
29207668
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"The inhibitory effect of Zn 2+ treatment on Src activity was also pronounced in the absence of pyrithione These results confirmed that Zn 2+ -induced EGFR phosphorylation is independent of Src kinase [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16410015
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"Abolition of SRC kinases-mediated EGFR phosphorylation has been shown to inhibit EGF-induced proliferation and/or transformation in many types of cancer cells, such as breast cancer cells and cervical cancer cells [ xref , xref ]."
26849234
rlimsp
"While, EGFR can phosphorylate Src at Y416 position, oncogenic Src (v-Src) can lead to phosphorylation of EGFR at Y845 site [58]."
22957061
sparser
"Previous reports about the involvement of AnxA2 in transportation of Src to the membrane led us to investigate whether AnxA2 downregulation interferes with EGF-induced phosphorylation of Src by EGFR."
22957061
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"Mechanistically, as an epidermal growth factor receptor (EGFR)‐binding protein, KIAA1199 promotes EGFR signaling and regulates EGFR‐dependent Src, Erk, and Akt phosphorylation, as well as downstream kinases in the EGF‐mediated EMT pathway."
32519472
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"In contrast, blockade of the EGFR by AG1478 inhibited phosphorylation of ERK1/2 but not Src or Akt phosphorylation following H (2) O (2) exposure."
15075181
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"In the present study, we showed that the c-Src inhibitor PP2 significantly blocked Ang II induced EGFR phosphorylation, while EGFR shRNA had no effect on Ang II induced c-Src phosphorylation."
26762600
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"These ligands activated EGFR, as well as ABL1, EPHA6, and SRC that were phosphorylated and activated by EGFR."
31694343
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"Another point of interest is the fact that the two partners in the well-known bidirectional activatory trans-phosphorylation between EGFR and Src, where Src phosphorylates the EGFR [XREF_BIBR - XREF_BIBR], and the EGFR phosphorylates Src [XREF_BIBR], are regulated by CaM, albeit in different manners."
26058065
sparser
"21,26 On the other hand, the epidermal growth factor receptor phosphorylates and activates Src, which, in turn, phosphorylates Tks5."
19464300
rlimsp
"Consistent with this idea, Src was hyperphosphorylated and associated with EGFR in NSCLC cell lines harboring mutant EGFRs, and these cells are more sensitive to Src inhibitors for cell death than cells expressing wtEGFR (Song ; Yang ; Zhang )."
19305428
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"Diabetes augmented and treatment with PP2 inhibited the phosphorylation of Src Tyr 416, EGFR Tyr 1173, and p38 and ERK1/2 (XREF_FIG)."
23942551
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"The cannabinoid induced activation of the EGFR leads to the subsequent phosphorylation and activation of the adaptor protein Src homology 2 domain containing (shc), and downstream activation of the ERK1/2 and Akt and PKB pathways."
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