IndraLab

Statements

MALT1 activates CYLD. 6 / 7
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"JNK activation has been connected to MALT1 catalysed CYLD cleavage XREF_BIBR."
27068814
reach
"In addition, MALT1 promotes lymphocyte activation by cleaving A20 and CYLD, deubiquitinating enzymes that have inhibitory roles in the NF-kappaB and JNK pathway, respectively XREF_BIBR, XREF_BIBR, and by cleavage of BCL10, which promotes lymphocyte adhesion XREF_BIBR."
23977204
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"To further confirm that MALT1 protease mediated the cleavage of MCPIP1 in macrophages, we used siRNA to knockdown MALT1 expression in macrophages, confirming that MALT1 promoted MCPIP1, but not A20, CYLD, BCL10 or RelB, degradation."
29263935
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"Taken together, our findings identify an important role for MALT1-mediated CYLD cleavage in BCR signaling, NF-κB activation and cell proliferation, which provides novel insights into the underlying molecular mechanisms and clinical potential of inhibitors of MALT1 and ubiquitination enzymes as promising therapeutics for DLBCL, MCL and potentially other B-cell malignancies."
36922488
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"At the same time, MALT1 could function as a protease activity upon TCR and CD28 co-stimulation to inactivate negative regulators of NF-kappaB signaling such as the A20 (also known as TNFAIP3), CYLD (cylindromatosis), RNase Regnase-1 as well as RelB and HOIL1 [XREF_BIBR - XREF_BIBR]."
27105502
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"The requirement for MALT1 mediated CYLD cleavage for intact JNK signaling downstream of the TCR has been previously described XREF_BIBR."
23335970